60 citations
,
January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that inhibiting PKC-β activity with bisindolylmaleimide reduces pigmentation in the skin and hair of guinea pigs and mice by preventing tyrosinase activation.
51 citations
,
March 1987 in “Journal of The American Academy of Dermatology” This study found that twice-daily application of 3% topical minoxidil maintained a higher nonvellus hair count compared to once-daily application over 2 years and 9 months in men with male pattern baldness.
47 citations
,
July 2005 in “British Journal of Dermatology” This study found no protective effect of topical calcipotriol on hair loss in chemotherapy patients, and the authors propose the term "atrophic telogen effluvium" for this type of hair loss.
36 citations
,
September 1999 in “Toxicologic pathology” This study suggests that hairless dogs' skin shows sensitivity to topical corticosteroids, highlighting their potential as a model for studying the efficacy and adverse effects of these treatments on skin.
33 citations
,
April 1990 in “Dermatologic Clinics” Minoxidil effectively treats hair loss, with better results in women.
30 citations
,
April 1990 in “Clinical Pharmacology & Therapeutics” This study found that coadministering minoxidil with tretinoin cream increased minoxidil absorption nearly threefold in healthy males, attributed to increased stratum corneum permeability.
25 citations
,
May 1986 in “The American Journal of the Medical Sciences” In this study, 53% of patients with male pattern baldness experienced significant hair growth with one year of topical minoxidil, while 95% rated its effectiveness as moderate or excellent.
20 citations
,
March 1994 in “Clinical and Experimental Dermatology” In this case report, a 16-year-old girl developed generalized hypertrichosis after using excessive doses of topical minoxidil for diffuse alopecia, which resolved four months after stopping treatment.
19 citations
,
March 2011 in “Cutaneous and Ocular Toxicology” Some chemicals absorbed through the skin can cause serious health problems.
16 citations
,
January 1986 in “Dermatology” In this study, 1% minoxidil lotion led to good results in 18% of male patients with androgenetic alopecia, but only 6% maintained regrowth one year after stopping treatment.
14 citations
,
June 2014 in “Journal of Pharmaceutical Sciences” This study validated the differential stripping technique on hairless rat skin and found that the P-08–016 formulation delivered more finasteride to the epidermis and appendages compared to P-10–008.
12 citations
,
August 2017 in “Archives of Pharmacal Research” In this study, lecithin-based microparticle formulations of minoxidil showed enhanced skin penetration and comparable hair growth effectiveness to commercial products in mice, while minimizing skin irritation often seen with standard minoxidil solutions.
5 citations
,
January 2020 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)” This study found that PRP was effective for treating alopecia areata with similar improvement across groups, while topical delivery via fractional CO2 laser or microneedling reduced injection pain.
4 citations
,
August 2020 in “Facial plastic surgery & aesthetic medicine” This study found that combining concentrated growth factor injections with minoxidil treatment significantly improved hair growth and participant satisfaction in male patients with androgenetic alopecia compared to minoxidil alone.
2 citations
,
March 2020 in “International Journal of Molecular Sciences” This article reviews advanced strategies for enhancing drug delivery to cutaneous stem cells to improve treatment for skin conditions and reports no new experimental findings.
2 citations
,
January 2020 in “International Journal of Cosmetic Science” In this in vitro study, niacinamide was found not to stimulate VEGF synthesis across a wide range of doses.
2 citations
,
January 2018 in “Elsevier eBooks” This review discusses the use of lipid nanoparticles for topical and transdermal delivery of pharmaceuticals and cosmeceuticals and reports no new clinical results.
1 citations
,
April 2020 in “Clinical, Cosmetic and Investigational Dermatology” In this study, topical acyclovir significantly delayed hair growth initiation and completion in mice and reduced hair follicle size, suggesting potential inhibitory effects on hair growth.
1 citations
,
April 2017 in “Journal of Investigative Dermatology” This study found that the novel IPC analog SIG-1451 may inhibit inflammatory cytokine release in cell-based assays relevant to allergic dermatitis.
July 2026 in “Pharmacological Reports” In this pilot study, topical latanoprost acid was observed to increase hair count and improve hair follicle structure in women with androgenetic alopecia, with no serious adverse events, suggesting potential for further investigation to confirm its efficacy and safety.
November 2021 in “International journal of life science and pharma research” This study reported that a solid lipid nanoparticle-based gel formulation, specifically optimized for psoriasis, improved drug loading capacity and release properties using high-pressure homogenization, suggesting its potential efficacy as a topical treatment.
April 2017 in “Journal of Investigative Dermatology” In this study, the novel isoprenylcysteine analog SIG-1451 was shown to inhibit pro-inflammatory cytokine release in various cell-based assays relevant to allergic dermatitis, acting on targets such as IL-4 and IL-6 with potential anti-inflammatory benefits.
April 2016 in “Journal of Urology and Nephrology Open Access” This abstract discusses treatment options for benign prostatic hyperplasia and provides no new clinical results.
32 citations
,
January 2019 in “American Journal of Clinical Dermatology” This review discusses the use of topical minoxidil for various types of alopecia and reports mixed evidence on its efficacy, with stronger support noted for conditions like eyebrow hypotrichosis and chemotherapy-induced alopecia.
23 citations
,
December 1995 in “Archives of Dermatology” This case report discusses a 32-year-old man's treatment for advanced androgenetic alopecia using a combination of topical minoxidil and oral finasteride, but no clinical outcomes are detailed.
11 citations
,
January 1987 in “Dermatology” In this study, 56% of men meeting specific criteria for hair loss experienced cosmetically acceptable hair growth with 2% topical minoxidil after one year, while frontotemporal hair loss did not improve.
3 citations
,
January 2016 in “Annals of Dermatology” This study suggests that 2% minoxidil and Kerium may promote hair regrowth in rats, while Aminexil showed the least effect among tested treatments; human-use products varied in efficacy in this animal model.
This study focused on developing a nanoemulsion-based gel for delivering minoxidil, aiming to enhance its contact time with the scalp and potentially improve skin absorption compared to conventional topical solutions.
December 2023 in “International Journal of Biomedicine” In this review, researchers explored the potential of topical finasteride as an innovative treatment for male pattern hair loss, addressing the limitations of oral finasteride, such as side effects and inconsistent effectiveness.
January 2021 in “Research journal for veterinary practitioners” This study evaluated a commercial topical solution with essential fatty acids for its potential effectiveness in treating skin disorders in rabbits.