23 citations
,
July 2008 in “British journal of dermatology/British journal of dermatology, Supplement” This review discusses the use of contact sensitizers for topical immunotherapy in dermatological conditions such as alopecia areata and viral warts, but it reports no new clinical findings.
55 citations
,
June 2013 in “Dermatologic Surgery” This review discusses the use of ablative and nonablative fractional resurfacing for enhanced topical drug delivery in dermatology and reports no new clinical results; further studies are needed to explore these methods.
7 citations
,
October 2024 in “AAPS PharmSciTech” This study developed a caffeine-loaded solid lipid nanoparticle gel, observing significant reduction in subcutaneous fat tissue thickness in histological tests compared to an untreated group, suggesting it could effectively treat cellulite as a promising nanocosmeceutical gel.
3 citations
,
March 2016 in “Journal of Cosmetic Dermatology” This study found that the penta-peptide Gly-Pro-Ile-Gly-Ser increased the proportion of thick hair and improved baldness appearance in Japanese men with androgenetic alopecia.
74 citations
,
July 1991 in “The Journal of Urology” This study found that topically applied minoxidil was more effective than nitroglycerin and placebo in enhancing penile diameter, rigidity, and arterial flow, with the most pronounced effects in patients with neurogenic impotence.
January 2011 in “Side effects of drugs annual” Tretinoin gel is safe for sun exposure, but tacalcitol doesn't significantly improve non-segmental vitiligo.
32 citations
,
December 1999 in “Journal of Investigative Dermatology Symposium Proceedings” This study found that the effectiveness of 17-beta-estradiol in inhibiting hair growth depends on its application method, and noted significant sex differences in response to 17-alpha-estradiol in male and female mice.
24 citations
,
April 2007 in “European Journal of Pharmaceutics and Biopharmaceutics” This study found that artocarpin delivered via alginate/chitosan microparticles effectively suppressed the growth of hamster flank organs compared to artocarpin in solution form, without significant systemic effects.
1 citations
,
January 2023 in “Research Square (Research Square)” This study found that a neem-based herbal formulation may be more effective than ivermectin in treating sarcoptic mange in dromedary camels, leading to complete recovery without scarring or keratinization.
December 2025 in “Pharmaceutics” In this study, araliadiol, a plant-derived compound, exhibited senomorphic effects in three dermal fibroblast senescence models, suggesting its potential as a topical treatment to mitigate skin aging by reducing certain senescence-related markers and increasing procollagen type I content.
127 citations
,
June 2006 in “International Journal of Pharmaceutics” This research found that liquid-state liposomes and niosomes may enhance finasteride delivery to pilosebaceous units in hamsters more effectively than gel-state vesicles or hydroalcoholic solution.
30 citations
,
May 1999 in “Food and chemical toxicology” This study suggests that topical procyanidin B-2 is safe for use as a hair growth agent, as it showed no mutagenic effects or significant irritation in a series of toxicological tests.
May 2017 in “Journal of The American Academy of Dermatology” This phase 2 trial found that SM04554, a Wnt signaling modulator, was well-tolerated and increased follicle counts in males with androgenetic alopecia, suggesting potential for promoting hair growth.
January 2005 in “Nihon Yasei Doubutsu Igakkaishi/Japanese journal of zoo and wildlife medicine” This study observed that Aloe vera gel applied topically to mange-affected camels led to the rapid disappearance of skin lesions and mites.
10 citations
,
January 1996 in “Journal of Dermatological Treatment” In this study, a standardized 7.5% herbal extract significantly increased hair growth in men with androgenetic alopecia compared to a placebo over a 48-week period.
November 2015 in “Chemical & engineering news” This study reported that topical drugs regrew hair in mice.
37 citations
,
March 1986 in “Acta Dermato Venereologica” In this study, there was no significant difference in hair growth between patients with extensive alopecia areata treated with 1% minoxidil and those receiving a placebo.
30 citations
,
December 1972 in “Archives of dermatology” This report examines efforts to enhance the efficacy of topical steroids for alopecia areata using penetration-enhancing vehicles and exceptionally high concentrations, noting systemic steroids often lead to relapses and toxicity.
13 citations
,
May 2021 in “FASEB bioAdvances” This review discusses plant-based alternatives to retinoids for dermal antiaging and hair health, highlighting roles for cytokinins and phytoestrogens and reports no new results.
This research focused on formulating finasteride, dutasteride, and minoxidil with cyclodextrins to enhance their solubility and skin penetration for topical use, potentially reducing scalp irritation from current alcohol-based preparations.
5 citations
,
January 1994 in “Skin Pharmacology and Physiology” This study found that minoxidil forms a reservoir in the skin, allowing sustained drug delivery even after cleansing, while propylene glycol does not.
2 citations
,
July 2023 in “Journal of Cosmetic Dermatology” This study evaluated a new topical regenerative treatment and found it can safely and effectively reduce hair loss in patients with androgenetic alopecia and telogen effluvium by mimicking the effects of autologous platelet-rich plasma.
January 2023 in “Journal of clinical pharmacy and therapeutics” This study found that isoliensinine, a natural compound identified from a database, effectively prevented stress-induced hair greying in mice by blocking β-2 adrenergic receptors on melanocyte stem cells in hair follicles.
January 1990 in “Springer eBooks” Some chemicals can permanently or temporarily remove color from skin and hair, which can be distressing and is not well-regulated in cosmetics.
13 citations
,
May 2021 in “Plants” This study found that the n-hexane fraction from Leea indica leaves significantly increased hair growth in mice and showed potential as a natural treatment for alopecia.
March 2026 in “Journal of Drug Delivery and Therapeutics” This review suggests that Aloe vera has potential benefits for various skin conditions by integrating Unani medicinal concepts with contemporary biomedical evidence.
March 2024 in “International journal of nanomedicine” This review discusses recent advancements in the development and use of polymer-based nanohydrogels for topical drug delivery, noting their potential to enhance drug loading, release control, and skin penetration for treating dermatological conditions.
16 citations
,
June 2008 in “Springer eBooks” Over 50% of women over 50 experience hair loss, with minoxidil being the only proven effective treatment.
8 citations
,
January 2011 in “Collection of Czechoslovak Chemical Communications” This study developed and validated a sensitive method using adsorptive cathodic stripping voltammetry to directly determine minoxidil in topical solutions, shampoos, and creams, achieving high recovery rates and precision.
5 citations
,
January 2022 in “Asian Journal of Pharmaceutical and Clinical Research” In this review, the authors highlight that emulgels, a combination of gel and emulsion, provide an effective topical drug delivery system for hydrophobic drugs, offering benefits like controlled release and versatility in treating various dermatological conditions.