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Glossary Topical Steroid

medication applied to skin to reduce inflammation and immune response

A topical steroid, also known as a topical corticosteroid, is a medication applied directly to the skin to reduce inflammation and suppress the immune response. It is commonly used to treat conditions like eczema, psoriasis, and alopecia areata by decreasing redness, swelling, and itching.

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research Systemic Steroids With or Without 2% Topical Minoxidil in the Treatment of Alopecia Areata

101 citations , November 1992 in “Archives of Dermatology”

In this study, tapering prednisone followed by 2% topical minoxidil helped limit hair loss in some patients with alopecia areata, with 30% to 47% showing over 25% hair regrowth initially.

research THERAPEUTIC HOTLINE: Effectiveness of the association of cetirizine and topical steroids in lichen planus pilaris - an open-label clinical trial

9 citations , September 2010 in “Dermatologic therapy”

This study found that combined therapy with cetirizine and topical steroids stabilized inflammation in most patients with lichen planus pilaris, though one patient experienced cardiac arrhythmia.

research The use of biodegradable microneedle patches to increase penetration of topical steroid for prurigo nodularis.

5 citations , January 2018 in “PubMed”

In this study, applying a biodegradable microneedle patch after topical steroid application significantly increased steroid penetration and improved treatment outcomes in patients with prurigo nodularis compared to the control.

research High‐Potency Topical Steroids: An Effective Therapy for Chronic Scalp Inflammation in Rapp–Hodgkin Ectodermal Dysplasia

3 citations , February 2016 in “Pediatric dermatology”

This report describes two cases of Rapp–Hodgkin ectodermal dysplasia where refractory scalp erosions improved significantly with potent topical steroids; it also suggests a potential link between these scalp conditions and erosive pustular dermatosis of the scalp in elderly patients.

research Ingestion of topical steroid triggering pustular psoriasis?

1 citations , August 2005 in “British Journal of Dermatology”

This case report describes a 7-year-old girl who developed widespread erythroderma and systemic symptoms after ingesting clobetasone butyrate cream, despite previous psoriasis treatment.

research Comparison of autologous platelet concentrates and topical steroids on oral lichen planus: a systematic review and meta-analysis

1 citations , June 2024 in “BMC Oral Health”

In this study, autologous platelet concentrates and topical steroids similarly reduced lesion size, Thongprasom scale, and pain in oral lichen planus patients, suggesting autologous platelet concentrates as a potential alternative treatment.

Scalp Atrophy Secondary to Steroid Use in Patients With Scarring Alopecia: Are Topical Steroids Superior to Topical Calcineurin Inhibitors?

research Scalp atrophy secondary to steroid use in patients with scarring alopecia: are topical steroids superior to topical calcineurin inhibitors?

1 citations , November 2023 in “International Journal of Dermatology”

This commentary discusses whether topical steroids or topical calcineurin inhibitors are better for treating scalp atrophy caused by steroid use in patients with scarring alopecia, but specific results or conclusions are not provided.

research Evaluation of the efficacy of topical metformin 10% and 20% versus topical potent steroid in the treatment of patients with alopecia areata

October 2025 in “Archives of Dermatological Research”

Topical metformin gel is as effective and safe as steroids for treating alopecia areata.

Comparative Study Between Ablative Fractional Carbon Dioxide Laser Combined With Topical Steroid Versus Topical Steroid in Treatment of Alopecia Areata

research Comparative Study Between Ablative Fractional Carbon Dioxide Laser Combined with Topical Steroid Versus Topical Steroid in Treatment of Alopecia Areata

October 2025 in “Iraqi postgraduate medical journal”

This study observed that using fractional CO2 laser-assisted delivery of clobetasol propionate cream significantly improved treatment outcomes for localized alopecia areata compared to the cream alone, suggesting the laser's enhancing effect on hair regrowth.

A Cross-Sectional Study to Characterize the Topical Steroid Dependent Face by Dermoscopy at a Tertiary Care Center

research A cross-sectional study to characterise the topical steroid dependent face by dermoscopy at a tertiary care centre

November 2024 in “IP Indian Journal of Clinical and Experimental Dermatology”

Dermoscopy is a useful tool for diagnosing and managing topical steroid dependent face.

research Topical calcipotriol mixed with topical steroid versus topical steroid alone in treatment of alopecia areata

January 2019 in “Egyptian Journal of Dermatology and Venereology /Egyptian Journal of Dermatology and Venerology”

This study investigated the efficacy and safety of a gel combining topical calcipotriol and steroid for alopecia areata. It found the combination worked similarly to steroids alone in reducing hair loss, but with fewer side effects.

research Atypical Morphological Patterns of Topical Steroid-Modified Dermatophytosis: A Cross-Sectional Study in South Asia

June 2026 in “Barind Medical College Journal”

In this study, researchers examined 1,000 South Asian patients misusing topical corticosteroids for dermatophytosis and found that this misuse resulted in atypical, chronic, and recurrent fungal infections called steroid-modified dermatophytosis, often involving extensive and atypical skin presentations.

Topical Sodium Valproate-Loaded Nanospanlastics Versus Conventional Topical Steroid Therapy in Alopecia Areata: A Randomized Controlled Study

research Topical sodium valproate-loaded nanospanlastics versus conventional topical steroid therapy in alopecia areata: a randomized controlled study

January 2024 in “Archives of dermatological research”

In this clinical study, researchers reported that both sodium valproate-loaded nanospanlastics and topical corticosteroids showed comparable modest efficacy in treating patchy alopecia areata, recommending further investigation into sodium valproate's role combined with other therapies.

research Drug utilization of topical and systemic steroids in treating various skin diseases in the dermatology department of a teaching hospital, Bangalore

January 2023 in “International Journal of Pharmacy and Pharmaceutical Science”

In this observational study conducted in Bengaluru, India, among 272 dermatology patients, the authors reported that dermatitis was the most common condition treated with corticosteroids, with a preference for topical applications; desonide was the most frequently prescribed drug.

Comparative Study Between Topical Steroid Alone Versus Combined Fractional Erbium:YAG Laser With Topical Steroid In Treatment Of Alopecia Areata

research Comparative Study between Topical Steroid alone versus Combined Fractional Erbium:YAG laser with Topical Steroid in Treatment of Alopecia Areata

April 2022 in “Research Square (Research Square)”

In this study, both topical clobetasol propionate and fractional Er: YAG laser followed by topical steroids demonstrated significant improvement in patients with alopecia areata, but the combined laser and steroid treatment was found to be more effective and safe.

research Infiltrative Erythemas and Nodules on a Unilateral Cheek Following Inappropriate Use of a Topical Steroid

February 2022 in “Institutional Repositories DataBase (IRDB)”

This case study describes a unique instance of unilateral steroid-induced rosacea-like dermatitis likely due to long-term localized use of topical corticosteroids, emphasizing the need for careful application and thorough histopathological analysis.

research Infiltrative Erythemas and Nodules on a Unilateral Cheek Following Inappropriate Use of a Topical Steroid

January 2022 in “Yonago Acta Medica”

This case report describes a Japanese woman with unilateral steroid-induced rosacea-like dermatitis attributed to long-term topical corticosteroid use, highlighting the significance of appropriate steroid application and histopathological evaluation for facial erythematous nodules.

A Comparative Study of the Outcomes of Potent Topical Steroids Versus Topical Tretinoin in Patchy Alopecia Areata of the Scalp

research A comparative study of the outcomes of potent topical steroids versus topical tretinoin in patchy alopecia areata of scalp

December 2019 in “International Journal of Research in Dermatology”

In this randomized study, 72% of patients treated with 0.05% betamethasone dipropionate showed significant improvement in limited patchy alopecia areata compared to 36% of those using 0.05% tretinoin, suggesting BMD is more effective but further research on tretinoin is needed.

research Combination treatment of extensive and recalcitrant alopecia areata with oral and topical steroids with topical minoxidil: An open-label study of efficacy and safety in pediatric patients

January 2016 in “Indian Journal of Paediatric Dermatology”

This study found that a combination treatment using oral and topical steroids with topical minoxidil was well-tolerated in children with severe recalcitrant alopecia areata, showing good responses except in alopecia universalis cases.

research Injudicious Use of Topical Steroids, A Misconcept in Treatment of Patients with Acne Vulgaris

July 2012 in “DOAJ (DOAJ: Directory of Open Access Journals)”

This study shows that many acne patients use topical steroids despite their association with various skin side effects, such as worsened acne, perioral dermatitis, and telangiectasias.

research TOPICAL STEROIDS

September 1996

This article discusses the potency grading of steroid skin creams and highlights that very potent or potent steroids (grades I and II) can cause significant side effects, especially in children.

research Injudicious Use of Topical Steroids, A Misconcept in Treatment of Patients with Acne Vulgaris -

January 2012 in “Journal of Islamic International Medical College”

This study found that 62% of acne patients used topical steroids, which were associated with several skin side effects like aggravation of lesions and perioral dermatitis.

research The use of liposomes in the topical application of steroids

33 citations , May 1984 in “Journal of Pharmacy and Pharmacology”

This study found that while systemic absorption of DHT from liposomes was negligible, the topical biological effect was weaker compared to DHT dissolved in acetone on the female hamster flank organ model.

research The Hidden Epidemic of Topical Steroid Use: Prevalence and Impact Among Jordan’s General Population

September 2025 in “Clinical Cosmetic and Investigational Dermatology”

This study in Jordan found that topical corticosteroid use is common and often involves creams obtained without prescriptions, with only 61.3% of users aware of potential side effects, highlighting a need for better public education and regulation to prevent misuse.

research Cortexolone 17a-propionate: Preclinical profile of a new topical, skin selective, steroidal antiandrogen

April 2012 in “Journal of the American Academy of Dermatology”

Clofazimine may be effective for treating ashy dermatosis.

research Systemic steroids with or without 2% topical minoxidil in the treatment of alopecia areata

24 citations , November 1992 in “Archives of Dermatology”

This study found that a 6-week taper of prednisone led to more than 25% hair regrowth in 30% to 47% of alopecia areata patients, and applying 2% topical minoxidil helped maintain this growth.

research Steroid topical therapy and pulse dosing therapy for multifocal alopecia areata

January 2003 in “Journal of Practical Aesthetic and Plastic Surgery”

This study found that intralesional Diprospan injections and high-dose intravenous methylprednisolone may be effective for treating longstanding multifocal alopecia areata, with variable hair regrowth observed among patients.

research Evaluation of an eucalyptus oil containing topical drug delivery system for selected steroid hormones

75 citations , August 2006 in “International Journal of Pharmaceutics”

The eucalyptus oil system improved skin delivery of hormones, but safety concerns remain.

research “Impact of Growth Factor Concentrate Versus Topical Steriods With Antibiotics in Type 1 Tympanoplasty”

1 citations , August 2025 in “Annals of Otology Rhinology & Laryngology”

In this study, patients with chronic otitis media who underwent tympanoplasty and were treated with growth factor concentrate exhibited significantly lower rates of residual perforation and reperforation compared to those receiving topical steroids and antibiotics, although improvements in auditory outcomes were not significantly different.

Microneedling Combination With 5% Minoxidil and Systemic and Topical Steroids in Alopecia Areata Patients: Case Report

research Microneedling kombinasi minoksidil 5% dengan steroid sistemik dan topikal pada pasien alopesia areata: laporan kasus

September 2025 in “Intisari Sains Medis”

This case report from this study demonstrates the potential of treating severe alopecia areata with a combination of microneedling, minoxidil, desoximetasone, and methylprednisolone, noting initial hair regrowth after 14 days but emphasizing the need for further research to confirm long-term efficacy and safety.