18 citations
,
May 2015 in “Australasian Journal of Dermatology” This study found that topical application of Serenoa repens extract increased hair count in men with androgenetic alopecia, suggesting it could be an alternative for those unable to use standard medications.
13 citations
,
May 2021 in “FASEB bioAdvances” This review discusses plant-based alternatives to retinoids for dermal antiaging and hair health, highlighting roles for cytokinins and phytoestrogens and reports no new results.
3 citations
,
January 2016 in “Annals of Dermatology” This study suggests that 2% minoxidil and Kerium may promote hair regrowth in rats, while Aminexil showed the least effect among tested treatments; human-use products varied in efficacy in this animal model.
January 2022 in “International Journal of Health Science” The authors of this study aim to evaluate the strategies for using topical products in treating androgenetic alopecia, highlighting topical applications as potentially more effective and convenient compared to oral medications, which often suffer from poor patient adherence.
122 citations
,
December 2022 in “International Journal of Molecular Sciences” In this review, researchers discussed recent advances in nanotechnology for topical skin applications, highlighting how nanocarriers enhance skin penetration and targeting in treatments for diseases like melanoma and psoriasis, while acknowledging that the penetration mechanisms and health impacts of nanoparticles remain not fully understood.
August 2019 in “Journal of the American Academy of Dermatology” The product effectively improves hair volume in aging individuals.
7 citations
,
April 2009 in “Bioorganic & Medicinal Chemistry Letters” Diphenyl ethers can potentially reduce excess oil production when applied on the skin, helping treat conditions like acne.
5 citations
,
September 2011 in “Bioorganic & Medicinal Chemistry Letters” This study identified pantolactam based compounds as effective topical antagonists of the androgen receptor, reducing sebum components in a hamster model.
188 citations
,
October 2012 in “The AAPS Journal” This review discusses strategies for developing semi-solid topical generic products to match the quality of reference-listed drugs, using concepts like quality by design and reverse-engineering, but reports no new results.
January 2016 in “Mercer University Libraries (Mercer University)” This study found that an anhydrous gel formulation containing sertaconazole nitrate effectively penetrated the stratum corneum for treating fungal infections without causing irritation.
March 2026 in “Preprints.org” This study investigated the secretome of adipose mesenchymal stem cells and fibroblasts used in skin care products, finding 16 therapeutic pathways involving numerous signaling mechanisms, which may offer skin benefits through anti-inflammatory and regenerative effects.
14 citations
,
October 2020 in “Natural Products and Bioprospecting” This review discusses current topical treatments, natural products, and complementary therapies for androgenetic alopecia, but it reports no new clinical results.
June 2026 in “Homo Politicus (Academy of Humanities and Economics in Lodz)” The effectiveness of ingredients in anti-hair loss products varies, and clinical trials are crucial to determine their success.
11 citations
,
May 2010 in “Journal of Medicinal Chemistry” This study introduced a novel nonsteroidal androgen receptor antagonist that effectively controls sebum production in the golden Syrian hamster ear model through targeted follicular delivery.
9 citations
,
July 1961 in “Journal of Investigative Dermatology” This study found that localized skin calcification could be induced in adult rats through dihydrotachysterol treatment combined with topical trauma, offering an experimental model for calcifying scleroderma.
1 citations
,
January 1991 in “Journal of Dermatological Treatment” In this study, 2% minoxidil applied topically did not alter scalp sebum levels, despite promoting hair growth in some participants.
November 2024 in “American Journal of Biomedical Science & Research” This abstract does not provide study results but outlines that acne is influenced by factors like androgens, sebum production, abnormal keratinization, and inflammatory reactions involving lymphocytes, macrophages, and neutrophils.
11 citations
,
March 2009 in “Bioorganic & Medicinal Chemistry Letters” This study reports that 4-(alkylthio)- and 4-(arylthio)-benzonitriles showed moderate sebum reduction as androgen receptor antagonists when applied topically in a validated animal model.
11 citations
,
August 2007 in “Bioorganic & Medicinal Chemistry Letters” This study found that among the tested analogs, compound 4e was the most effective in inhibiting wax esters in vivo in the Golden Syrian hamster ear model.
39 citations
,
March 2008 in “Growth hormone & IGF research” Raspberry ketone may help grow hair and improve skin elasticity.
5 citations
,
July 2022 in “PubMed” This study identified the most common allergens in hair products linked to scalp allergic contact dermatitis, with hair dyes, shampoos, and conditioners primarily associated with the condition.
19 citations
,
July 1993 in “Journal of Applied Toxicology” This study found that various petroleum distillates caused significant skin changes in mice, with severity varying based on the product and penetration pathway, potentially leading to skin tumors through non-genotoxic mechanisms in longer-term exposure.
6 citations
,
September 2024 in “Metabolism and Target Organ Damage” This review discusses the role of skin enzymes in drug metabolism and emphasizes the need for models assessing enzyme activity to evaluate the safety and bioequivalence of topical generic drugs, highlighting efforts to standardize testing protocols for transdermal products.
December 2024 in “Skin Appendage Disorders” Researchers reviewed 13 clinical trials on non-prescription monotherapies like procyanidin and cetirizine for androgenetic alopecia, finding potential improvements in hair density and diameter, but emphasized the need for more robust trials to confirm efficacy and safety.
In their review, the authors discussed the increasing issue of allergies to hair products, highlighting common allergens such as hair dyes and topical minoxidil, and outlined diagnostic methods and alternatives for those affected, particularly addressing higher risks among hairdressers due to professional exposure.
69 citations
,
March 2016 in “American journal of clinical dermatology” Topical retinoids effectively improve photodamaged skin.
17 citations
,
August 2007 in “Bioorganic & Medicinal Chemistry Letters” This study found that a specific amino-pyridine compound showed potent androgen receptor antagonist activity, stimulating hair growth in mice and reducing sebum production in a hamster model.
1 citations
,
May 2017 in “Journal of The American Academy of Dermatology” The moisturizer with phytol improved skin texture and reduced fine wrinkles better than the moisturizer without it.
August 2017 in “Journal of the Dermatology Nurses' Association” This article reviews the usage, efficacy, side effects, and alternatives of topical bimatoprost 0.03% for dermatological applications but does not present new clinical findings.
March 2014 in “Journal of The American Academy of Dermatology” The new topical product combined with finasteride significantly increased hair thickness without side effects.