3 citations
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January 2023 in “Journal of Pharmaceutical Negative Results” This study reports that fluconazole emulgel formulations, using jojoba oil and liquid paraffin, showed effective drug release and improved characteristics for treating skin diseases compared to traditional oral formulations.
19 citations
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July 2020 in “Journal of drug delivery science and technology” This study found that nano-sized minoxidil formulations significantly increased skin penetration and follicular drug delivery for alopecia areata treatment, compared to conventional ethanol-based solutions, and demonstrated effective controlled release over six hours.
1 citations
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October 2024 in “Dermatology Practical & Conceptual” In this double-blind randomized controlled trial, both rosemary extract lotion and 2% ketoconazole lotion were effective for treating scalp seborrheic dermatitis, but rosemary lotion reduced itching more significantly, while ketoconazole was more effective in reducing dandruff.
This study focused on developing a nanoemulsion-based gel for delivering minoxidil, aiming to enhance its contact time with the scalp and potentially improve skin absorption compared to conventional topical solutions.
13 citations
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February 2019 in “Journal of Microencapsulation” This study focused on designing a niosome formulation that encapsulates pumpkin seed oil for topical use, achieving high entrapment efficiency and stability over three months.
47 citations
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May 2021 in “Polymers” This review surveys the chemical composition and various uses of jojoba oil in medicine and industry but presents no new clinical results.
19 citations
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November 2011 This review discusses the topical use of systemic drugs for cutaneous disorders and reports a lack of strong evidence from randomized controlled trials, highlighting the need for larger comparative effectiveness studies.
January 2004 in “Side effects of drugs annual” Certain skin drugs and topical agents, including some natural extracts and fragrances, can cause allergic reactions. Some hair dyes and extensions, as well as minoxidil, a hair growth treatment, can also cause allergies. Botulinum toxin A can effectively reduce sweat but may have temporary side effects.
14 citations
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October 2020 in “Natural Products and Bioprospecting” This review discusses current topical treatments, natural products, and complementary therapies for androgenetic alopecia, but it reports no new clinical results.
1 citations
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October 2013 in “Actas Dermo-Sifiliográficas” This review discusses the current role and challenges of compounding in dermatology without presenting new research results; the authors suggest its resurgence in practice despite pharmaceutical alternatives.
7 citations
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July 2022 in “Pharmaceuticals” This study reports that pumpkin seed oil-loaded niosomes significantly decreased hair loss and increased hair growth indicators in vivo, suggesting potential as a natural anti-hair loss therapy.
8 citations
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February 2010 in “Journal of Dermatology” This study observed that a topical liposome formulation of a 5‐α‐reductase inhibitor effectively reduced the size of treated sebaceous glands and induced apoptosis in a hamster model, suggesting potential benefits for acne treatment.
April 2025 in “Pharmaceutics” This study examined three olive oil formulations of baricitinib for topical delivery in treating alopecia areata, finding that Oil A showed the highest skin retention and maintained skin integrity without irritation, suggesting its potential for further investigation.
June 2025 in “Journal of the Faculty of Medicine Baghdad” This study found that Syzygium aromaticum oil may improve the anagen/telogen ratio in testosterone-induced alopecia in mice, indicating potential as an alternative treatment to minoxidil for androgenic alopecia.
November 2022 in “International Journal of Applied Pharmaceutics” This study found that phytosterols extracted from moringa seed oil may act as potential anti-alopecia agents by inhibiting the 5α-reductase enzyme, with ergostadienol showing particularly high affinity and stability in in silico simulations.
May 2024 in “Journal of medicinal food” This review highlights jojoba oil's unique composition and its growing therapeutic applications, noting its antioxidant, anti-acne, antidiabetic, and antibacterial properties, as well as its use in various pharmaceutical formulations.
February 2020 in “International research journal of pharmacy” This study suggests that a topical emulsion containing Camellia sinensis and Allium cepa extracts may show promise for treating alopecia areata in Wistar rats.
17 citations
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September 2024 in “Cosmetics” This study assessed the antioxidant properties and contents of carotenoids and chlorophylls in 10 plant oils, finding fenugreek seed oil to be highest in carotenoids and pomegranate oil most active against free radicals, highlighting their potential as natural materials with antioxidant benefits.
10 citations
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June 2019 in “International Journal of Cosmetic Science” This review discusses the potential benefits of phytochemicals for hair care and emphasizes the need for more robust preclinical and clinical studies, without reporting new clinical results.
1 citations
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September 2017 in “Journal of Investigative Dermatology” This study reported that introducing the TERT and Bmi1 genes into mouse dermal papilla cells resulted in immortal cells capable of inducing new hair follicles in vivo, and human immortal DPCs were also developed.
1 citations
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June 2023 in “Journal of Patchouli and Essential Oil Products” This literature review suggests that patchouli essential oil may help reduce eczema symptoms in infants and young children due to its anti-inflammatory, antimicrobial, and antioxidant properties, though it highlights the need for further standardized studies to confirm optimal use and safety.
January 2025 in “International Journal of Trichology” This review highlighted the hype surrounding topical hair growth ingredients such as Redensyl, Procapil, and others, noting promising results but also emphasizing the limitations of existing studies, including small sample sizes and lack of standard therapy comparisons.
December 2023 in “Azerbaijan Pharmaceutical and Pharmacotherapy J” This study formulated a minoxidil-loaded submicron emulsion-based topical gel, which demonstrated effective in vitro release, ex vivo permeation, and stability, suggesting it may offer a targeted treatment approach for alopecia compared to traditional methods.
122 citations
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December 2022 in “International Journal of Molecular Sciences” In this review, researchers discussed recent advances in nanotechnology for topical skin applications, highlighting how nanocarriers enhance skin penetration and targeting in treatments for diseases like melanoma and psoriasis, while acknowledging that the penetration mechanisms and health impacts of nanoparticles remain not fully understood.
51 citations
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September 2015 in “Medical Clinics of North America” This review discusses common skin appendage diseases, including their pathophysiology and treatments, but does not report new results.
11 citations
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December 2018 in “Assay and Drug Development Technologies” This review highlights the challenges in screening for steroid 5 alpha-reductase inhibitors and discusses significant variability in the effectiveness of finasteride and dutasteride, calling for standardized testing methods to develop safer, more specific inhibitors from herbal preparations.
January 2026 in “Indus journal of bioscience research.” In this study, Hibiscus rosa-sinensis extract was used to formulate and evaluate herbal cosmetic creams for their antioxidant properties, stability, and effectiveness. The formulations demonstrated strong antioxidant potential, stability under various conditions, and favorable cosmetic qualities, suggesting HRS as a beneficial ingredient in skincare products.
November 2025 in “Discover Pharmaceutical Sciences” In this study, a nanoemulsion containing lavender, peppermint, and rosemary essential oils was developed and shown to promote hair growth in mice at a rate comparable to 2% topical minoxidil, suggesting a promising natural alternative due to its antioxidant and anti-inflammatory effects.
Some TikTok hair loss remedies like rosemary oil, onion juice, and garlic gel show promise, but more research is needed and they might delay proper treatment.
67 citations
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February 2020 in “Journal of Ginseng Research” This review evaluates and classifies the non-saponin components of Korean Red Ginseng, emphasizing their combined role with saponins in the plant's bioactivity, but reports no new clinical results.