October 2024 in “Biology” This review discusses the role of dermal papilla cells in hair follicle formation and their potential use in cell therapy for hair loss, but reports no new research findings.
This study found that Polygonum multiflorum radix ethanol extract may promote melanin synthesis, potentially helping to turn gray hair back to black by enhancing antioxidant activity and increasing tyrosinase expression.
2 citations
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June 2023 in “Gels” This study highlights the versatility and potential of injectable hydrogel nanocomposites in biomedical research, emphasizing their roles in controlled drug delivery, tissue regeneration, and treatment of various conditions, such as cardiac issues, joint diseases, and bone regeneration.
15 citations
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June 2023 in “Molecules” This study focused on developing agarose/fucoidan hydrogels for the encapsulation of pancreatic cells, reporting that these materials supported cell viability and self-organization into pseudo-islets over 7 days, highlighting potential for diabetes treatment applications.
1 citations
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December 2025 in “Journal of Investigative Dermatology” Photocrosslinkable biomaterials can improve wound healing by controlling mechanical environments.
181 citations
,
December 2017 in “Trends in immunology” This review discusses the roles and interactions of intestinal intraepithelial lymphocytes in maintaining mucosal barrier integrity and highlights how their dysregulated responses may contribute to intestinal pathologies.
75 citations
,
September 2015 in “Acta biomaterialia” This study found that alkylation of kerateine cysteine residues created a cell-compatible method for controlling hydrogel erosion rates and therapeutic agent release in keratin-based systems.
55 citations
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September 2020 in “Frontiers in Bioengineering and Biotechnology” This review discusses surface engineered metal-organic frameworks for wound healing and reports no new clinical results; it highlights their potential as antibacterial agents, therapeutic delivery systems, and wound dressings.
31 citations
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August 2023 in “ACS Applied Bio Materials” This study developed granular hydrogels with reversible interparticle cross-linking, finding they offer high mechanical stability and enhance cell recruitment, making them promising for injectable and 3D printable scaffolds in tissue engineering and therapeutic delivery.
21 citations
,
November 2015 in “Phytomedicine” This study found that glycyrrhizic acid significantly reduced stem cell characteristics of dermal papilla cells by down-regulating key signaling pathways, suggesting potential use in suppressing unwanted hair growth.
14 citations
,
September 2025 in “Gels” This review reports that sodium alginate-based hydrogels show promise in biomedical applications due to their biocompatibility and versatility, but challenges such as mechanical strength and stability remain, highlighting the need for continued research to facilitate their clinical transition.
13 citations
,
December 2021 in “Molecules” This review discusses the potential uses of inorganic nanomaterials for imaging and detecting brain diseases, but reports no new experimental results; it calls for improvements in diagnosis precision and imaging accuracy.
4 citations
,
November 2025 in “Molecules” This review reports that cerium oxide nanoparticles may accelerate wound healing in animal models, but further standardized and comparative studies are needed to confirm their potential for clinical applications.
4 citations
,
May 2025 in “International Journal of Nanotechnology and Nanomedicine” This review highlights recent advances in the design of nanocarrier systems for transdermal drug delivery, detailing their potential to improve treatment precision for dermatologic conditions despite challenges like formulation stability and scalability.
May 2026 in “Nature Communications” In this study, researchers identified that keloid fibroblasts respond to neurotransmitters from catecholaminergic nerves by producing bone matrix proteins, mediated by β1-adrenergic receptor activation, leading to fibro-osseous reprogramming; blocking this signaling in a rodent model prevented the development of keloid-like pathology.
April 2026 in “Pharmaceutics” This review highlights cellulose-based materials' potential in skin disease treatments, emphasizing their smart, responsive design for various conditions, with insights into their roles in wound healing, infection prevention, and wearable monitoring.
13 citations
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May 2021 in “FASEB bioAdvances” This review discusses plant-based alternatives to retinoids for dermal antiaging and hair health, highlighting roles for cytokinins and phytoestrogens and reports no new results.
4 citations
,
August 2025 in “Molecules” This study highlights the potential of medicinal plants like Rubus vulgaris and Plantago major as sources for skin disorder treatments due to their bioactive compounds' antioxidant, anti-inflammatory, and antimicrobial effects.
January 2025 in “Pharmaceuticals” This review discusses the potential of peptide-based hydrogels as biomaterials for treating chronic wounds and reports no new clinical findings.
213 citations
,
September 2020 in “Journal of Functional Biomaterials” This review discusses bio-based polymers, highlighting their potential in wound healing applications, but reports no new clinical results.
1 citations
,
December 2025 in “International Journal of Molecular Sciences” This review reports that chitosan-based systems with metal nanoparticles and polyphenols may enhance wound healing by improving the bioavailability and stability of these compounds, suggesting a potential new approach for chronic and diabetic wounds.
517 citations
,
February 2010 in “Materials” This review discusses the history and development of keratin biomaterials for biomedical uses, highlighting their biological activity and biocompatibility, and provides no new research findings.
203 citations
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May 2022 in “Pharmaceutics” This review discusses ongoing concerns and advancements in the use of gelatin as a biomaterial in tissue engineering, highlighting improved tissue mimicry through techniques like 3D bioprinting and suggesting a future focus on disease detection and diagnosis rather than treatment.
169 citations
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October 2020 in “Pharmaceutics” This review discusses recent advancements in formulating electrospun nanofibers as wound dressings, emphasizing their advantages in incorporating bioagents for improved healing, but reports no new clinical results.
106 citations
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December 2015 in “Biomacromolecules” This study describes a method to create keratin hydrogels with adjustable erosion rates by mixing different ratios of keratose and kerateine, enabling controlled release of therapeutic agents like insulin-like growth factor 1.
81 citations
,
March 2022 in “Frontiers in Bioengineering and Biotechnology” This review discusses advancements and challenges in bioengineered scaffolds for wound healing but presents no new experimental findings, highlighting their potential and need for further development.
61 citations
,
April 2023 in “Bioactive Materials” This review article highlights recent advances in microneedle technology for wound healing and tissue regeneration, discussing various cargo types, structural designs, and fabrication methods, and suggesting guidelines for designing microneedle systems tailored to specific applications.
57 citations
,
November 2024 in “Aggregate” This review article highlights recent advancements in smart hydrogels as promising solutions for diabetic wound management, emphasizing their ability to respond to wound environments and deliver targeted therapies, while addressing limitations of traditional dressings.
44 citations
,
February 2023 in “Cell” In this study, researchers found that human fingerprint ridges are formed through a modified hair follicle developmental process and spatial patterns influenced by specific signaling pathways.
25 citations
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November 2022 in “Frontiers in Bioengineering and Biotechnology” This review discusses the integration of biodegradable biomaterials with drugs and stem cells for diabetic wound repair, but reports no new clinical results and highlights the need for further translation to clinical practice.