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Tofacitinib citrate is effective for moderate-to-severe chronic plaque psoriasis but has safety concerns at higher doses.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

A protein called EGFR protects hair follicle stem cells, and when it's disrupted, hair follicles can be damaged, but blocking certain pathways can restore hair growth.

Personalized treatment plans combining natural and synthetic approaches are important for managing alopecia effectively.

The mTOR signaling pathway is crucial for hair health and targeting it may lead to new hair loss treatments.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.

Cellular senescence has both cancer-blocking and cancer-promoting effects, and targeting senescent cells may improve health and lifespan.

The document concludes that various findings in rheumatology offer insights into disease severity, treatment responses, and potential risks in medication, with some limitations due to unspecified participant numbers.

TNF-a may not be as involved in certain types of hair loss as previously thought.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

Pantethine may boost the immune system's ability to fight sarcoma.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

Hair loss from Alopecia Areata is caused by both genes and environment, with several treatments available but challenges in cost and relapse remain.

Dutasteride injections can help hair growth in androgenic alopecia but need more research for long-term use.

Blocking certain immune signals can reduce skin damage from radiation therapy.

Th22 cells are essential for Tβ15-induced hair growth in mice.

Both vitiligo and alopecia areata involve an immune response triggered by stress and specific genes, with treatments targeting this pathway showing potential.

Tocilizumab treatment was associated with significant hair regrowth in one patient and temporary hair loss followed by regrowth in another.

Skin problems are common in lupus, often appearing first, with various types and treatments, and careful monitoring is important for diagnosis and management.

The hexosamine pathway helps protect skin cells from stress and may improve skin and hair health.

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

Photobiomodulation therapy using red and near-infrared light can reduce inflammation and aid in healing various conditions.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

Targeting CD200 could be a new treatment for rheumatoid arthritis.

Keratin 17 is modified by RSK1 in response to growth and stress, affecting skin growth and stress response.

Imiquimod cream activates hair follicle stem cells and causes early hair growth by changing immune cells and certain protein expressions.

CRTH2 antagonists might be useful for treating many conditions because they play a role in immune and inflammation responses.