research Precision Dermatology: A Review of Molecular Biomarkers and Personalized Therapies
Personalized medicine in dermatology uses molecular biomarkers to improve diagnosis and treatment but needs further advancements for practical use.
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research Treatment of Cultured Sebocytes with an EGFR Inhibitor Does Not Lead to Significant Upregulation of Inflammatory Biomarkers
Blocking EGFR in skin cells doesn't majorly increase inflammation markers.
research Hair Loss Induced by Tumor Necrosis Factor Alpha Inhibitors
Some drugs used to treat immune conditions may cause different types of hair loss.
research Granulomatous Scarring Alopecia Associated With Rheumatoid Arthritis: A Case Report
A woman with rheumatoid arthritis had a unique type of scarring hair loss not caused by infection, requiring early treatment to avoid permanent hair loss.
research Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition
Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.
research Development of Alopecia Areata Universalis in a Patient Receiving Adalimumab
Adalimumab may cause severe hair loss in some patients.
research Effects of Dermatological Medications on Male Fertility
Some dermatological medications can impair male fertility, so consult a doctor before trying to conceive.
research Genetics of Hidradenitis Suppurativa
Hidradenitis Suppurativa has genetic links, with certain gene mutations more common in patients and a third of cases having a family history.
research An Open-Label Phase II Study of the Safety and Efficacy of Etanercept for the Therapy of Hidradenitis Suppurativa
Etanercept is safe and may help improve hidradenitis suppurativa, but more research is needed.
research Onset of Lichen Planopilaris During Treatment with Etanercept
Etanercept may cause lichen planopilaris, so doctors should be cautious.
research Infliximab Induced Lupus in Crohn's Disease
Infliximab can trigger lupus-like symptoms in Crohn's disease patients.
research Disorders of Hair Growth and the Pilosebaceous Unit: Facts and Controversies
Experts don't fully agree on how to diagnose certain hair growth disorders and more research is needed to understand them better.
research New Populations with Increased Cardiovascular Risk: Cardiovascular Disease in Dermatological Conditions
Some skin conditions may increase the risk of heart disease, but are not yet included in cardiovascular prevention guidelines.
research Proteasome Inhibitors: An Expanding Army Attacking a Unique Target
Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.
research The Phytocannabinoid (–)-Cannabidiol Operates as a Complex, Differential Modulator of Human Hair Growth: Anti-Inflammatory Submicromolar Versus Hair Growth Inhibitory Micromolar Effects
CBD can either reduce inflammation and not affect hair growth at low levels or inhibit hair growth at high levels.
research Dermatologic Toxicities Associated with Chronic Gamma-Secretase Inhibitor Treatment for Desmoid Tumor
Most patients experienced mild to moderate skin problems during a trial for a desmoid tumor treatment.
research Identification of Dkk4 as a Target of Eda-A1/Edar Pathway Reveals an Unexpected Role of Ectodysplasin as Inhibitor of Wnt Signaling in Ectodermal Placodes
Ectodysplasin inhibits Wnt signaling to help form hair follicles.
research Wound Healing: A Cellular Perspective
The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
research RANK as a Therapeutic Target in Cancer
RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.
research A Hot New Twist to Hair Biology: The Role of TRPV1 in Human Hair Growth Control
Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.
research A Novel Therapeutic Paradigm for Patients with Extensive Alopecia Areata
New treatments targeting immune pathways show promise for severe hair loss but need more research for safety and effectiveness.
research Fibrosing Alopecia in a Pattern Distribution
FAPD and possibly CCCA may be AGA subtypes, and treatments combining antiandrogens, hair growth agents, hair transplants, and anti-inflammatories could be effective.
research Deficiency of the Human Cysteine Protease Inhibitor Cystatin M/E Causes Hypotrichosis and Dry Skin
Not having enough cystatin M/E protein causes less hair growth and dry skin.
research Alopecia Induced by Tumor Necrosis Factor-Alpha Antagonists: Description of 52 Cases and Disproportionality Analysis in a Nationwide Pharmacovigilance Database
Some drugs used to treat inflammation may cause hair loss.
research Predictive Modeling of Patient Response to JAK/STAT Inhibitors and Dynamic Patient-Matching
Machine learning can predict how well patients with alopecia areata will respond to certain treatments.
research TNF Superfamily in Skin Appendage Development
TNF family proteins are crucial for the development of skin features like hair, teeth, and mammary glands.
research Anti-TNF Antibody-Induced Psoriasiform Skin Lesions in Patients with Inflammatory Bowel Disease Are Characterised by Interferon-γ-Expressing Th1 Cells and IL-17A/IL-22-Expressing Th17 Cells and Respond to Anti-IL-12/IL-23 Antibody Treatment
Anti-IL-12/IL-23 antibody therapy effectively treats psoriasiform skin lesions in IBD patients.
research The Wnt Inhibitor, Dickkopf 4, Is Induced by Canonical Wnt Signaling During Ectodermal Appendage Morphogenesis
The study found that the protein Dkk4 helps regulate hair growth by controlling Wnt signaling in mice.
research Localization of Plasminogen Activator Inhibitor Type 2 in Hair and Nail: Implications for Terminal Differentiation
PAI-2 helps in the maturation and protection of hair and nail cells.
research Short-Chain Fatty Acids from Cutibacterium Acnes Activate Both a Canonical and Epigenetic Inflammatory Response in Human Sebocytes
Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.