November 2022 in “Journal of Investigative Dermatology” This study found that in mouse melanocytes, the cytoplasmic dynein complex component Dynlt3 is necessary for proper melanosome transport, acidity regulation, and effective transfer to keratinocytes, linking it to skin pigmentation processes.
October 2022 in “Faculty of 1000 Research Ltd” This review discusses the roles of various growth factors and cytokines in skin regeneration, highlighting their potential for future therapeutic development, and reports no new experimental findings.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This source reviews current research on using exosomes for treating alopecia and finds promising preclinical evidence, particularly with exosomes from dermal papilla and adipose-derived stem cells. However, it highlights significant gaps in clinical translation regarding safety, delivery, and mechanisms, suggesting more rigorous studies are needed.
June 2022 in “Frontiers in Immunology” This report describes a case of alopecia universalis successfully treated with tofacitinib, though it was associated with increased peripheral blood cytokine levels.
April 2022 in “Journal of applied science and environmental management” This study found that Aframomum melegueta seed extract improved wound healing in albino rats, with treated groups showing smaller wound sizes and formation of new tissues compared to controls.
April 2022 in “Journal of Investigative Dermatology” Hair shaft miniaturization leads to hair follicle stem cell loss, suggesting Piezo1 as a potential treatment target.
April 2022 in “International journal of respiratory and pulmonary medicine” The authors propose that higher testosterone levels in hospitalized COVID-19 patients might be associated with worse outcomes.
August 2021 in “Research Square (Research Square)” This study found that BEO inhibited cell proliferation and inflammatory mediator release in a human keratinocyte acne model and reduced acne lesion severity in a rabbit model, suggesting its potential as a natural alternative to conventional acne treatments.
This study reports the case of a 12-year-old girl who developed psoriatic alopecia after increasing her dose of the TNF-α inhibitor adalimumab for Crohn's disease, emphasizing psoriatic alopecia as a phenomenon associated with these medications.
April 2021 in “Research Square (Research Square)” This study found that the new cocrystal formulation KET-PABA improved the antimycotic efficiency of ketoconazole and induced an anti-inflammatory response without causing skin sensitization in mice.
December 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that IL-1β may play a role in inflammatory signaling pathways in papulopustular rosacea, contributing to its pathogenesis.
In this study, topical application of piperonylic acid was observed to accelerate wound healing in mice by enhancing EGFR activation, keratinocyte modulation, and collagen deposition, suggesting its potential as a treatment for skin injuries.
This review summarizes recent genetic research on hidradenitis suppurativa, highlighting potential therapeutic targets and genetic mutations, but reports no new clinical findings.
April 2020 in “Research Square (Research Square)” In this study, PBMCs from women with PCOS showed reduced TNF-α production over time, potentially limiting their antitumor response to breast cancer cell lines compared to healthy controls.
March 2020 in “The Egyptian Journal of Histology” This study found that topical olive oil may protect mice skin from damage caused by electromagnetic radiation, particularly when applied before exposure, by mitigating oxidative, inflammatory, and heat shock stress factors.
January 2020 in “Archives of Medicine and Health Sciences” This review discusses potential biomarkers for alopecia and their significance, and while it highlights areas for future research, it reports no new clinical results.
January 2019 in “Springer eBooks” Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.
July 2018 in “Elsevier eBooks” This review discusses the diagnosis of alopecia in psoriasis, highlighting different hair loss types and the need to distinguish it from similar conditions, but reports no new clinical results.
January 2018 in “Springer eBooks” Hidradenitis Suppurativa is likely an autoinflammatory disease, and better understanding its causes could improve treatments.
January 2018 in “Springer eBooks” Different races and genders have unique skin and hair issues, requiring specialized care and more research for effective treatment.
January 2018 in “Hair transplant forum international” This article discusses a novel multi-targeting approach to treating hair loss using standardized nutraceuticals but reports no new clinical results.
December 2017 in “The Sri Lanka Journal of Dermatology” This study reports a case where treatment with the TNF alpha inhibitor infliximab successfully resolved refractory alopecia universalis in a 41-year-old woman.
May 2017 in “Journal of The American Academy of Dermatology” LED light helps human hair root cells grow and move by activating certain cell pathways.
January 2017 in “Springer eBooks” This article reviews the classification, pathogenesis, and treatment options for cutaneous lupus erythematosus and reports no new clinical findings.
August 2016 in “Journal of Investigative Dermatology” This quiz based on a Journal of Investigative Dermatology article reports no new clinical results but serves as an educational tool for diagnosing scalp conditions, including scalp psoriasis and psoriatic alopecia.
July 2016 in “Cancer Research” This study developed a topical botanical lotion for managing chemotherapy-induced hair loss in cancer patients, reporting that it improved hair recovery times by 5-16 weeks, reduced inflammation, and enhanced scalp collagen levels with no observed side effects.
April 2016 in “Journal of Investigative Dermatology” This study found that a single high dose of oral vitamin D reduced UV-induced skin erythema and inflammation in humans by enhancing autophagy, suggesting new clinical avenues for skin repair.
April 2016 in “Journal of Investigative Dermatology” This study suggests that lithocholic acid may enhance hair regeneration in alopecia by activating vitamin D receptors in human dermal papilla cells.
In this study, serum IL-13 and TGF-β concentrations were significantly different between alopecia areata patients and controls, suggesting a role for these cytokines in the disease's pathogenesis.
October 2015 in “Journal of the East Asian Society of Dietary Life” This study found that oral administration of Curcuma longa L. extract in castrated rats with benign prostate hyperplasia reduced pro-inflammatory cytokine expression, suggesting a potential anti-inflammatory effect.