January 2013 in “edoc (University of Basel)” This study found that TRF1 plays a crucial role in maintaining pluripotency and stem cell compartments, but it is not a suitable in vivo telomere length marker.
February 2025 in “Journal of Clinical Investigation” This study found that RNase L acts as a regeneration repressor gene in mammals, as seen in Rnasel-/- mice which showed increased regenerative capacity and elevated Wound Induced Hair Neogenesis through enhanced IL-36α signaling, suggesting a tradeoff between regeneration and immune regulation.
5 citations
,
November 2014 in “Hair transplant forum international” This article introduces a series on low level laser light therapy, focusing on its science, regulatory aspects, and controlled trial methodologies, but reports no new clinical results.
3 citations
,
May 2025 in “Cell Death and Disease” This study found that METTL1 is upregulated in papillary thyroid cancer tissues and promotes cancer cell proliferation and metastasis through its tRNA methyltransferase activity.
2 citations
,
December 2019 in “Al-ʻulūm al-ṣaydalāniyyaẗ” This study found no evidence that CTLA-4 gene polymorphism (rs733618) plays a role in polycystic ovarian syndrome among the participants.
36 citations
,
March 2014 in “Annals of the Rheumatic Diseases” This study found that activating liver X receptors with an agonist reduced skin fibrosis in experimental models, particularly in inflammation-driven conditions, by inhibiting macrophage infiltration and interleukin-6 release.
2 citations
,
March 2010 in “Acta Biochimica Polonica” This study observed that conjugates of the anticancer drug raltitrexed with dextran and albumin were more cytotoxic than the free drug at high concentrations, altering cell cycle effects.
July 2025 in “Journal of Investigative Dermatology” TRIV-509 quickly improves skin barrier and cell health in atopic dermatitis.
May 2026 in “Discover Oncology” This review discusses the role of LGR4 in tumors, highlighting its involvement in cancer progression, metastasis, and chemotherapy resistance, as well as its regulatory effects on tumor stem cell self-renewal and stem cell characteristics, based on multiple recent studies.
2 citations
,
June 2026 in “Frontiers in Science” This review examines the potential of regulatory T cell-based therapies to transform treatment across various medical specialties by promoting immune tolerance and tissue repair, but it reports no new clinical results.
38 citations
,
January 2016 in “Cell Death and Disease” This review discusses the role of the TCL1 transgenic mouse model in understanding chronic lymphocytic leukemia biology and highlights the importance of exploring new pathogenetic and therapeutic targets.
75 citations
,
July 2016 in “New phytologist” This study found that RSL4 in Arabidopsis thaliana regulates genes necessary for root hair elongation by controlling proteins involved in cell signaling, cell wall modification, and secretion.
40 citations
,
July 2023 in “Clinical Pharmacology & Therapeutics” This review discusses the progress and challenges of targeted protein degradation therapies, highlighting the increasing number of degraders in cancer clinical trials and the limited diversity in targeted proteins, primarily focusing on those employing CRL4CRBN as the E3 ligase.
January 2025 in “Medical Research Archives” This review discusses various applications of low level laser therapy and argues for a holistic evaluation of patients but reports no new clinical findings.
This study found that the long non-coding RNA lnc056 promotes the proliferation of hair follicle stem cells by upregulating TRIP6 expression through interaction with the transcription factor HNRNPUL1, suggesting a potential target for hair loss treatment.
June 2011 in “CRC Press eBooks” Low-Level Laser Therapy can stimulate healing and cell function, potentially leading to wider medical use.
11 citations
,
September 2011 in “Biochemical journal” This study found that neurotrophin-4 regulates Cav3.2 T-current expression in D-hair neurons via TrkB receptor activation, highlighting its role in mechanosensitive function.
1 citations
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January 2015 in “Hair transplant forum international” This review discusses low level laser therapy for hair loss but reports no new research findings; it serves as an introduction to understanding existing knowledge before upcoming evaluations of recent studies.
January 2026 in “Journal of Dermatological Science” This study suggests that DcR3 can reprogram macrophages towards a reparative state, enhancing wound healing and hair follicle regeneration, making it a potential target for treating chronic wounds and alopecia.
July 2026 in “Theranostics” This study developed a novel ferritin-based delivery system (LR@Fn) that effectively co-delivers RG108 and LLY283 for hearing loss treatment in animal models, reducing hair cell loss and synaptic damage more effectively than dexamethasone.
22 citations
,
September 2011 in “Journal of Investigative Dermatology” This study found that impaired TCF/Lef1 signaling in mice leads to significant skin barrier defects due to altered lipid metabolism and epidermal differentiation.
1 citations
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December 2022 in “Frontiers in Immunology” This review summarizes recent findings about the multi-site differentiation of tissue regulatory T cells, emphasizing the pivotal role of epigenetic remodeling, but it reports no new clinical results.
5 citations
,
February 2022 in “Stem cell reports” This study found that thymic stromal lymphopoietin (TSLP) promotes hair growth after skin injury by enhancing the proliferation of specific stem cells in hair follicles.
December 2014 in “Journal of Biomedical Research” In a mouse model of peripheral vascular disease, this study found that recombinant thymosin β4 treatment increased expression levels of certain proteins, promoting angiogenesis.
4 citations
,
May 2015 in “Hair transplant forum international” The review concluded that better studies are needed to prove if Low-Level Laser Therapy devices for hair growth really work.
44 citations
,
June 2017 in “The EMBO Journal” This study reports that the autotaxin–LPA–LPA3 signaling pathway at the embryo-epithelial boundary plays a critical role in decidualization by up-regulating HB-EGF and COX-2 in the uterine epithelium.
May 2010 in “OPAL (Open@LaTrobe) (La Trobe University)” This research discusses potential cancer vaccine strategies using cell-based and DNA vector-based approaches, and suggests targeting the v3 splice variant of thioredoxin reductase 1 to inhibit cancer cell motility and metastasis formation.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that TLR3 activation in human keratinocytes enhances exosome biosynthesis and expression of hair follicle stem cell markers, suggesting a potential mechanism for tissue regeneration.
5 citations
,
May 2022 in “Diagnostics” This study found that certain lncRNA gene polymorphisms in HOTAIR and MALAT1 are associated with increased susceptibility to systemic lupus erythematosus, potentially informing clinical applications.
July 2025 in “Journal of Investigative Dermatology” Ritlecitinib reduces alopecia areata symptoms by blocking JAK3/TEC signaling and T-cell activity.