January 2023 in “Dermatologic Therapy” This study evaluated a novel hand-held low-level light therapy device for treating mild-to-moderate acne, finding it significantly reduced inflammatory lesions and moderate acne severity without severe adverse reactions, while also reducing Cutibacterium acnes viability in vitro.
April 2026 in “International Journal of Clinical Case Reports and Reviews” In this preclinical study, researchers developed and evaluated a new non-invasive laser system designed for personalized medical use, showing its potential for chronic disease management and adjunctive fat reduction by offering enhanced treatment precision and adaptability over existing devices.
1 citations
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November 2024 in “Frontiers in Immunology” This study provides an analysis of global publications on TLS, offering insights into the role of TLS in immunotherapy and suggesting future research directions.
April 2020 in “The Aesthetics” This article discusses the applications and proposed benefits of LED low level light therapy for various conditions like acne, wound healing, and pain relief, but provides no new clinical results.
11 citations
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August 2010 in “Pediatric dermatology” This report details two cases of Lichen spinulosus in the submental area, treated effectively and safely with topical tacalcitol cream.
1 citations
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January 2015 in “Hair transplant forum international” This review discusses low level laser therapy for hair loss but reports no new research findings; it serves as an introduction to understanding existing knowledge before upcoming evaluations of recent studies.
2 citations
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January 2018 in “Recent clinical techniques, results, and research in wounds” This review discusses the effects of low-level laser therapy in various biological processes for wound healing and tissue repair and reports no new results.
October 2013 in “CRC Press eBooks” This review outlines current and potential cosmetic and dermatological applications of low-level light therapy, like photorejuvenation and hair regrowth, and reports no new clinical findings.
3 citations
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May 2025 in “Cell Death and Disease” This study found that METTL1 is upregulated in papillary thyroid cancer tissues and promotes cancer cell proliferation and metastasis through its tRNA methyltransferase activity.
January 2022 in “Figshare” This study found that knocking down lncRNA MTC in Liaoning Cashmere goat skin fibroblasts reduced cell proliferation and altered protein expression, suggesting its role in hair growth and regulatory pathways.
January 2005 in “Cosmetic Surgery Times” This study reports that the Luce LDS 100 infrared light therapy shows positive hair growth results after one year in men and women with androgenetic alopecia.
433 citations
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April 2015 in “Photomedicine and laser surgery” This editorial discusses the terminology and distinctions between Low-Level Light/Laser Therapy and Photobiomodulation Therapy but reports no new clinical findings.
22 citations
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September 2011 in “Journal of Investigative Dermatology” This study found that impaired TCF/Lef1 signaling in mice leads to significant skin barrier defects due to altered lipid metabolism and epidermal differentiation.
March 2024 in “Cytologia” In this study, researchers observed that melatonin-mediated LncRNA MTC in Liaoning cashmere goat skin fibroblasts enhances cell proliferation by interacting with the GSTM1 protein, affecting its complex formation with ASK1 and thereby inhibiting apoptosis, which may be relevant for improving cashmere growth.
This study found that TLR2 and its ligand CEP are crucial for maintaining hair follicle health and stimulating hair growth, with deficiencies observed in aging and obesity potentially reducing regeneration.
March 2026 in “Journal of the American Academy of Dermatology” In this study, patients with active lymphocytic cicatricial alopecia showed significant improvement using a three-stage treatment regimen involving Tofacitinib, Apremilast, and Crisaborole, with 93.5% experiencing marked improvement and only three mild adverse events reported.
June 2011 in “CRC Press eBooks” Low-Level Laser Therapy can stimulate healing and cell function, potentially leading to wider medical use.
9 citations
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October 2012 Tumescent local anesthesia is a safe, cost-effective method for outpatient liposuction.
April 2012 in “Informa Healthcare eBooks” Temporal triangular alopecia is a lifelong condition with hairless patches on the side of the head that may be present from birth.
2 citations
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January 2014 in “Journal of Cytology & Histology” In a mouse model, this study found that LAM/TSC cells invaded the uterus and increased angiogenesis, while anti-EGFR antibody and rapamycin effectively reduced cell presence and blood vessel proliferation.
August 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that TLR2 is crucial for maintaining hair follicle health and regeneration, and its stimulation by the metabolite CEP may promote hair growth, while decreases in TLR2 and CEP in aging and obesity may hinder hair growth.
This study found that activating Toll-like receptor 3 signaling in periodontal ligament stem cells may enhance their immunomodulatory properties, suggesting potential implications for future stem cell therapy applications.
1057 citations
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November 2011 in “Annals of Biomedical Engineering” This review discusses the applications of low level laser therapy (LLLT) in wound healing, pain reduction, and treating various conditions, but reports no new clinical results; the authors highlight the need for randomized controlled trials for serious diseases.
35 citations
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September 2011 in “The Journal of Dermatology” This article discusses the trichoscopic diagnosis of temporal triangular alopecia, but reports no new clinical results.
10 citations
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January 2010 in “Journal of cosmetic and laser therapy” This article describes a non-blinded study investigating low level laser therapy for seven patients but reports no new clinical findings.
4 citations
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May 2015 in “Hair transplant forum international” The review concluded that better studies are needed to prove if Low-Level Laser Therapy devices for hair growth really work.
November 2025 in “SKIN The Journal of Cutaneous Medicine” This review highlights the potential benefits of low-level light therapy for treating various alopecias, with reported improvements in hair density and count, especially when combined with minoxidil or finasteride, but it offers no new clinical results.
4 citations
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February 2014 in “Proceedings of SPIE” This review discusses the diverse applications of low-level laser therapy in aesthetic dermatology, especially for managing alopecia, but notes that comprehensive literature on its effectiveness is lacking.
January 2017 in “International journal of science and research” This review discusses treatment options for trichotillomania, focusing on cognitive-behavioral interventions and promising developments in combined pharmacotherapy and therapy approaches, but reports no new findings.
3 citations
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August 2024 in “Clinical Cosmetic and Investigational Dermatology” In this study, researchers found that specific treatment parameters disrupted follicles and sebaceous glands, damaging the bacteria Cutibacterium acnes and promoting follicular remodeling, which may improve both inflammatory and noninflammatory acne lesions.