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This review explores the potential of extracellular vesicle therapy as a novel strategy to delay intervertebral disc degeneration and enhance tissue repair, by modulating key pathogenic mechanisms, with a focus on the molecular components and bioengineering modifications of extracellular vesicles.

This review discusses how studying regenerative biology in certain mammalian models could enhance our understanding of complex tissue regeneration, but it reports no new clinical findings.

This study established a new in vitro culture system that supports the growth and dynamic self-organization of hair follicle stem cells and their progeny, promoting a stable population equilibrium.

This review discusses recent advancements in scar reduction techniques, highlighting promising therapeutic targets and the role of Wnt/β-catenin signaling in promoting scarless wound healing, but reports no new clinical results.

This study found that Wnt signaling regulates the symmetric division of adult neural stem cells, increasing their numbers during subependymal regeneration, stroke response, and colony formation.

In this study, researchers found that extrafollicular progenitors marked by Hic1 are the main contributors to reparative fibroblasts in wound repair, with potential to modulate healing outcomes through genetic and pharmacological interventions.

This study found that extracellular vesicles derived from hair follicle mesenchymal stromal cells demonstrated similar potential to those from adipose tissue in promoting cell proliferation and migration, enhancing angiogenesis, and protecting cells under stress, suggesting promise for chronic wound treatment.

This review discusses the roles of TGF-β family signaling in regulating normal and cancer stem cells and highlights the need for further research to develop potential cancer treatments; it reports no new results.

This study found that intradermal adipocyte lineage cells in mice are necessary and sufficient to activate follicular stem cells, highlighting their role in regulating skin stem cell activity.

This article discusses the coordinated roles of different epidermal stem cells and other cell types in the skin's wound healing process and reports no new experimental results.

This article reviews mammalian skin epidermis as a model for studying stem cell regulation, noting the utility of in vitro and ex vivo platforms, but it reports no new empirical findings.

This study found that rat whisker follicle stem cells can be expanded in culture and transplanted to form functional hair follicles, demonstrating their multipotency and potential for regenerative medicine.

In this study, the researchers found that deleting ceramide synthase 4 in the skin's epidermis alters stem cell differentiation, disrupting hair follicle structure and barrier function, potentially leading to immune responses similar to atopic dermatitis.

This article discusses the bi-compartmental organization of hair follicle stem cell niches for balancing stem cell cycling and organ growth and proposes similar structures may exist in other adult stem cell niches but reports no new experimental results.

Adding stem cells to fat grafts for facial rejuvenation might improve outcomes, but more research is needed to confirm safety and effectiveness.

This research examined the transcriptional landscape of quiescent melanocyte stem cells (qMcSCs) in adult female mice, revealing significant heterogeneity within this cell population and identifying novel subpopulations that vary in immune privilege regulation, melanocyte differentiation potential, and neural crest potential.

This review discusses various methods for obtaining stem cell-derived conditioned media and its applications in disease treatment, finding generally positive results but highlighting the need for standardized production methods.

Different types of stem cells and their environments are key to skin repair and maintenance.

This study found that combining platelet-rich plasma with adipose-derived mesenchymal stem cells significantly improved diabetic wound healing in rats by enhancing angiogenesis and modulating the Notch signaling pathway.

This review discusses hair follicle stem cells for wound healing and reports no new clinical results, noting their potential but emphasizing the need for further understanding and safety in clinical applications.

This study found that canine hair follicle stem cells are located in the isthmus/bulge region of the hair follicle, surrounded by telocytes.

This study found that a dopamine-methacrylated hyaluronic acid hydrogel enhances the efficacy of adipose-derived stem cells in promoting skin regeneration, potentially involving the Notch signaling pathway.

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

This review discusses various stem cell compartments in adult murine and human epidermis, examining their expressed markers and characterization assays, and reports no new experimental results.

Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.

This study found that light stimulation of intrinsically photosensitive retinal ganglion cells in the eyes can activate hair follicle stem cells through a neural circuit involving the sympathetic nervous system.

This study reports the creation of rat liver stem cell lines that can differentiate into hepatocytes and suggests they might be useful for pharmacological and regenerative medicine applications.

This review explores recent insights into how intrinsic gene oscillations and molecular interactions in hair follicle stem cells contribute to their regenerative potential, with potential implications for regenerative medicine, but reports no new clinical results.

This study found that cultured mouse dermal papilla (mDP) cells can induce hair follicle neogenesis in de novo regenerated skin tissues grafted onto mice.

This study established a new cell line from human hair follicle stem cells that maintains stem cell properties and differentiation capabilities, providing a useful in vitro model for stem cell research.