16 citations
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June 2025 in “Journal of Composites Science” This study investigated chitosan–hydroxyapatite biocomposites, finding them to enhance anti-inflammatory cytokine expression, support cellular activities, and reduce pro-inflammatory cytokines in a dermatitis model, while highlighting gaps in understanding their immune modulation and issues with reproducibility for clinical use.
1 citations
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March 2006 in “The FASEB journal” This study found that keratin scaffolds derived from human hair promoted excellent cell viability and showed minimal inflammatory response and vascular integration when tested in in vitro and in vivo settings.
203 citations
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July 2017 in “Biotechnology and Genetic Engineering Reviews” This review discusses the various components essential for successful tissue engineering, such as cell sources, modification methods, and supportive matrices, and highlights the need for functional synergy without reporting new experimental results.
2 citations
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February 2024 in “STAR Protocols” In this research, an optimized protocol was developed for dissociating human scalp tissue to produce high-quality single-cell suspensions suitable for single-cell RNA sequencing, aimed at studying the transcriptomics of human hair follicles.
1 citations
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August 2018 in “Journal of Investigative Dermatology” This study found that Muse cells retained their pluripotency and ability to differentiate into various cell types even after being cryopreserved multiple times.
February 2002 in “Dermatologic Surgery” Best hair transplant results happen when tissues are least damaged.
3 citations
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February 2013 in “Journal of Medicinal Plants Research” This study found that both crude Spirulina extract and C-phycocyanin showed similar effects on keratinocyte proliferation and wound healing, with C-phycocyanin performing better in tissue regeneration in vivo on the 7th day.
July 2026 in “International Journal of Pharmaceutics X” In this study, researchers developed a biopolymer-based dual-layer wound dressing that significantly improved healing outcomes in a 14-day rat model, reporting 94% wound closure by day 15 and enhanced tissue regeneration, swelling properties, and cell viability.
April 2025 in “Journal of Biophotonics” This study found that 808 nm laser photobiomodulation altered mitochondrial respiration and enhanced osteogenic protein expression in human dental pulp stem cells, with the effects being dose-specific and more pronounced at 15 J/cm².
October 2022 in “IntechOpen eBooks” This source highlights the challenges in treating cicatricial alopecia, noting that follicular unit extraction hair transplantation offers a minimally invasive and successful option to improve cosmetic outcomes for patients with permanent hair loss from scarring.
This research found that keratin hydrogels derived from human hair may support cell viability and proliferation, indicating potential as 2D and 3D soft tissue culture scaffolds.
688 citations
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June 2007 in “Cell Stem Cell” This study found that deleting the ATR gene in adult mice led to rapid onset of age-related traits such as hair graying and osteoporosis through reduced regenerative capacity.
20 citations
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September 2022 in “Journal of Biomedical Optics” This article reviews the potential of using PBM in 3D tissue engineering to improve cell viability under stress conditions but reports no new experimental findings.
2 citations
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May 2015 in “PloS one” This study found that radiation negatively impacts the survival and proliferation of fibroblasts on human dermis transplants, but hair follicle pores enhance cell viability even after irradiation.
October 2022 in “Hair Transplantation” This review discusses techniques for repairing large scalp defects, emphasizing the combination of older methods like scalp reduction and tissue expansion with modern hair restoration surgery to achieve satisfactory results, despite challenges like compromised scalp viability due to factors like trauma or radiation.
This study introduces a new type of tissue micromodule, the micro tissue precursor (μTP), which can form complex 3D tissues, including lung stroma and skin models supporting hair viability.
August 2025 in “Medicine and ecology” This review found that combining adipose-derived tissues and platelet-rich plasma improves fat graft survival and healing outcomes in reconstructive and aesthetic surgery, but variability in methodologies limits study comparability.
288 citations
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January 2001 in “Journal of Biological Chemistry” In this study, the disruption of Gh/tissue transglutaminase in mice did not affect viability but reduced thymocyte viability and fibroblast adhesion, suggesting its role in cell stabilization and extracellular matrix interactions.
69 citations
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February 2021 in “PLoS Computational Biology” This study found that securinine and ajmaline significantly inhibited hepatocellular carcinoma cell viability and induced apoptosis, with securinine showing lower toxicity to normal liver cells.
June 2026 in “Frontiers in Cell and Developmental Biology” In this review, researchers examined how needle gauge and length impact the viability of human stem cells during injections, emphasizing the balance between minimizing tissue trauma and preserving cell viability to optimize clinical protocols.
78 citations
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February 2024 in “ACS Omega” This study developed a bilayer material combining poly(vinyl alcohol) and bacterial cellulose with a gelatin-poly(vinyl alcohol) hydrogel, showing strong potential as a wound dressing due to its good antibacterial properties, cell viability, and sustained drug release.
11 citations
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June 2016 in “npj Regenerative Medicine” This symposium discussed why regenerative capacity varies among species and diminishes with age, exploring how these insights could inform regenerative medicine approaches, without presenting new experimental results.
3 citations
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September 2024 in “Frontiers in Bioscience-Scholar” This study reported that Pantaneiro sheep from the Pantanal region of Brazil exhibit greater genetic variability and adaptability compared to the commercial Texel breed, highlighting their potential for further research and importance in Brazilian sheep farming.
23 citations
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January 2015 in “Stem cells international” This study found that keratin coatings from human hair may improve the colony-forming efficiency of human mesenchymal stem cells by moderating donor variability, suggesting a potential use in clinical applications.
December 2025 in “Eastern Ukrainian Medical Journal” This study reviews current methods for making and using platelet-rich plasma and fibrin, emphasizing the variability in clinical outcomes due to differences in preparation protocols, and calls for standardized guidelines and large-scale studies for better effectiveness in regenerative medicine.
208 citations
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January 2013 in “Lab on a Chip” The researchers described a chip-based bioreactor platform for dynamic perfusion, which may enhance in vitro skin models by introducing mechanical shear stress and extending culture periods.
The systematic review reported promising outcomes for stem cell-enriched treatments in aesthetic medicine, such as improved skin rejuvenation, hair restoration, and scar revision. However, challenges like protocol variability and regulatory issues must be addressed to ensure effective and safe clinical applications.
May 2025 in “Medicine and ecology” This literature review highlights the widespread use of platelet-rich plasma in medicine but notes inconclusive evidence for its clinical efficacy due to specimen variability and unresolved methodological issues.
15 citations
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January 2014 in “BioMed Research International” This review discusses the concept of drug repositioning and highlights fragmin and protamine as emerging biomaterials for tissue engineering and regenerative medicine, but it reports no new clinical results.
14 citations
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November 2019 in “Mediators of inflammation” This study found that adipose-derived stem cell-conditioned media improved skin flap survival following ischemia/reperfusion injury in mice by increasing cell proliferation and the number of hair follicles, mediated by IL-6.