This study found that individuals with both androgenetic alopecia and metabolic syndrome had thicker subcutaneous adipose tissue in the frontal scalp, along with unfavorable metabolic parameters, compared to those without metabolic syndrome.
December 2022 in “Biological and Clinical Sciences Research Journal” This study found that among mixed connective tissue disease patients in a tertiary care hospital in Pakistan, Raynaud phenomenon was the most common clinical feature, present in 80% of patients.
February 2022 in “Book Publisher International (a part of SCIENCEDOMAIN International)” This study reports the demonstration of electromagnetic energy transfer from human blood tissue to a human hair follicle through a 1 mm glass barrier, using in vitro experiments.
March 2021 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study found that human dWAT regulates hair growth and pigmentation through HGF secretion, highlighting potential novel targets for treating hair growth and pigmentation disorders.
June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, mice fed various high-fat diets showed changes in dermal white adipose tissue lipid composition, with decreases in essential omega-3 fatty acids, which are important for skin health.
September 2019 in “Journal of Investigative Dermatology” This study found that in chronic alopecia areata, increased IL-17 expression and CD8+CD49a-Trm cell infiltration in hair follicles were associated with more severe histopathologic gradings, while Foxp3+mTreg infiltration decreased.
September 2018 in “Cumhuriyet medical journal” This study found that women with severe hirsutism have thicker subcutaneous abdominal fatty tissue and are more likely to develop metabolic syndrome compared to those with moderate hirsutism.
May 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found potential evidence of inducible skin-associated lymphoid tissue (iSALT) in alopecia areata patients undergoing topical immunotherapy, which may suggest an essential role in treatment efficacy.
This study found that dermal papilla-like tissues derived from canine adipose stem cells promoted new hair follicle formation and increased vascularization in athymic nude mice.
June 2014 in “Biotechnology and Bioprocess Engineering” This study demonstrated that injecting reconstructed dermal papilla-like tissues in mice led to new hair growth, suggesting potential future applications in hair transplantation and baldness treatment.
This study found that Mdm2 is critical for limiting p53 activity to maintain normal stem cell function in mouse skin, with impacts on tissue homeostasis and aging.
January 2011 in “Zhongguo shiyong fuke yu chanke zazhi” This study concludes that hormone therapy can significantly improve skin hydration, elasticity, thickness, and reduce wrinkles by modulating various skin cells through estrogen receptors.
January 1982 in “Japanese Journal of Clinical Immunology” This case study reports the rare occurrence of widespread soft-tissue calcification in a young patient with SLE, suggesting that 99mTe-phosphate compounds could help diagnose this complication.
November 2022 in “Journal of Nanobiotechnology” In this study, researchers used a new method with platelet-rich plasma-loaded microcarriers to enhance dermal papilla cell activity and hair follicle regeneration, achieving significant hair and vessel growth in a mouse model compared to control groups.
February 2021 in “International journal of regenerative medicine” In this study, emulsifying microfragmented adipose tissue increased the number of stromal vascular fraction cells available for regenerative treatments, suggesting the method's potential use in medical facilities.
30 citations
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January 2001 in “Journal of the American Veterinary Medical Association” This study found that adrenal sex hormone levels were elevated in neutered dogs with hypercortisolemia, except for testosterone, highlighting the importance of ruling out hypercortisolemia when diagnosing adrenal hyperplasia syndrome.
In this study, researchers developed a novel bio-patch from decellularized freeze-dried tumor tissues and hair melanin nanoparticles, which demonstrated enhanced wound healing in vivo by reducing oxidative stress, suppressing inflammation, and promoting angiogenesis.
289 citations
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May 2003 in “Journal of Investigative Dermatology” This study demonstrates that human skin is capable of steroid hormone synthesis, but its role in androgenic skin disorders like acne and alopecia is yet to be clarified.
166 citations
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September 2011 in “The Journal of Cell Biology” This study found that the p63 transcription factor plays a role in epidermal morphogenesis by regulating Satb1 expression, impacting chromatin architecture and gene expression in epidermal progenitor cells.
146 citations
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June 2012 in “PLoS ONE” This study observed that quiescent label-retaining cells in the intestine, identified by Paneth cell markers, can switch to a proliferative state and activate Bmi1 expression during tissue injury, contributing to tissue regeneration.
124 citations
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July 1997 in “Journal of Biological Chemistry” This study found that overexpression of an enzyme in transgenic mice led to distorted polyamine levels, resulting in permanent hair loss and female infertility.
88 citations
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July 2019 in “International Journal of Molecular Sciences” In this study of patients with Androgenic Alopecia, micro-grafts containing HD-AFSCs resulted in significantly improved hair density and follicle count over 11 months compared to a saline solution, suggesting a potential alternative therapy for hair regrowth.
47 citations
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June 2013 in “Biology of blood and marrow transplantation” This study presents a new mouse model for investigating chronic graft-versus-host disease, highlighting the role of human thymic tissue in developing multiorgan fibrosis driven by human immune cells.
46 citations
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July 2015 in “Wound repair and regeneration” This study found that keloid tissues exhibit epithelial-mesenchymal transition-related changes and alterations in gene expression, implicating these processes in the pathogenesis of keloids.
44 citations
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July 2020 in “Stem Cell Research & Therapy” This review discusses recent advancements in the study and application of epidermal stem cells for wound healing and tissue engineering, without presenting new experimental findings.
37 citations
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December 2001 in “Journal of Investigative Dermatology” This study found that human follicular papilla cells in the scalp produce leptin and express functional leptin receptors, suggesting leptin's significant role in hair biology.
36 citations
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February 2018 in “British Journal of Dermatology” In this study, researchers found that eccrine sweat glands in human scalp skin are morphologically integrated into the pilosebaceous unit, suggesting they form a common homeostatic tissue environment with adjacent structures.
35 citations
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August 2006 in “Molecular genetics and metabolism” This study found significant variation in tissue mutant load in individuals with the T8993G mutation, which complicates genetic counseling and may inform genotype-phenotype correlations, especially using hair bulb mtDNA analysis.
28 citations
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January 2021 in “Burns & Trauma” This study found that wound healing after scald burns in mice was slower in deeper burns, but the healing quality in second-degree deep scalds was similar to normal healing.
27 citations
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October 2020 in “Biomedicine & Pharmacotherapy” This study found that transplanting hair follicle bulge-derived stem cells in rats enhanced skin regeneration during expansion by differentiating into several skin-related cells and increasing the expression of growth factors.