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The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Wnt, Eda, and Shh pathways are crucial for different stages of sweat gland development in mice.

Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.

EZH2 levels decrease as fetuses develop and are higher in adult skin, which may affect skin growth and repair.

A device was made in 2008 to measure hair loss severity. Other findings include: frizzy mutation in mice isn't related to Fgfr2, C/EBPx marks preadipocytes, Cyclosporin A speeds up hair growth in mice, blocking plasmin and metalloproteinases hinders healing, hyperbaric oxygen helps ischemic wound healing, amniotic membranes heal wounds better than polyurethane foam, rhVEGF165 from a fibrin matrix improves tissue flap viability and induces VEGF-R2 expression, and bFGF enhances wound healing and reduces scarring in rabbits.

Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.

The document concludes that while some organisms can regenerate body parts, mammals generally cannot, and cancer progression is complex, involving mutations rather than a strict stem cell hierarchy.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

Tiny particles called extracellular vesicles could help with skin healing and hair growth, but more research is needed.

Certain fats in the skin help control inflammation and health, and changing these fats through diet or supplements might treat skin inflammation.

Keratinocytes show more TGF-β system activity and collagen production as they age, which might affect wound scarring.

Scientists successfully grew new hair follicles in regenerated mouse skin using mouse and human cells.

Older mice have stiffer skin with less elasticity due to changes in collagen and skin structure, affecting aging and hair loss.

PNKP is essential for keeping adult mouse progenitor cells healthy and growing normally.

Treating fat stem cells with low oxygen boosts hair growth cell growth through specific signaling pathways.

Secretome-based therapies could improve hair growth better than current treatments.

Immune cells are crucial for hair growth and preventing hair loss.

Different light affects cell functions and can help treat skin conditions.

Hair follicle stem cells can change their role to ensure proper hair development.

Double-stranded RNA helps regenerate hair follicles by increasing retinoic acid production and signaling.

Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.

Platelet-rich plasma shows promise for skin and hair treatments but needs more research and standardization.

New nanofiber technology improves wound healing by supporting cell growth and delivering treatments directly to the wound.

Stem cell niches support, regulate, and coordinate stem cell functions.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.

Keratin 15 is not a reliable sole marker for identifying epidermal stem cells because it's found in various cell types.

Platelet-rich plasma may help in skin and hair treatments, and with muscle and joint healing, but more research is needed to fully understand its benefits and limitations.

Restoring mitochondrial function in mice reversed their skin wrinkling and hair loss.