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Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Men's sensitivity to male hormones might affect how severe COVID-19 gets for them.

Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

The document concludes that hair is complex, with a detailed growth cycle, structure, and clinical importance, affecting various scientific and medical fields.

Survivors of Stevens-Johnson syndrome/toxic epidermal necrolysis need ongoing care for various long-term health problems.

No treatment fully prevents hair loss from chemotherapy yet.

Eating 500 fewer calories a day and making lifestyle changes can improve PCOS symptoms and reduce diabetes risk; more research is needed on its causes and treatments.

BMP2 and BMP7 have opposite roles in feather formation.

Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.

Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.

Drosha and Dicer are essential for hair follicle health and preventing DNA damage in skin cells.

SHISA6 helps maintain certain stem cells in mouse testes by blocking signals that would otherwise cause them to differentiate.

Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.

Aging mice have slower hair regeneration due to changes in signal balance, but the environment, not stem cell loss, controls this, suggesting treatments could focus on environmental factors.

Hair grays due to oxidative stress and fewer functioning melanocytes.

Male hormones are important for hair and oil gland development and can cause conditions like excessive hair growth and acne.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.

HFMs can help study hair growth and test potential hair growth drugs.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

The FOXN1 gene is crucial for developing immune cells and preventing immune disorders.

Women with PCOS have fewer activated T cells in their ovarian follicles, which might affect fertility.

Natural 5AR inhibitors effectively improve mild to moderate hair loss in men.

Cyclosporine A may help treat hair loss by blocking a protein that inhibits hair growth.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

Hair greying is caused by oxidative stress damaging hair follicles and melanocytes.

The hair follicle is a great model for research to improve hair growth treatments.

Toxic Shock Syndrome cases increased due to new factors, but decreased with public health measures and changes in tampon use.