126 citations
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August 2018 in “Molecular Systems Biology” This study found that in murine dermis, fibroblast state switching between proliferation and ECM deposition plays a crucial role in tissue architecture and wound healing.
23 citations
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October 2021 in “FEBS Journal” This review examines the role of Sonic Hedgehog signaling in the maintenance and repair of skin and lung barriers, and its influence on inflammation and atopic diseases; it presents no new clinical findings.
1 citations
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March 2019 in “KnE life sciences” This case report suggests that human dermal papillae conditioned media may accelerate wound healing in congenital aplasia cutis due to varicella infection.
January 2026 in “Wound Repair and Regeneration” This review summarizes the latest progress and challenges in skin organoid research, emphasizing advancements in organoid construction, applications in disease modeling, and factors affecting tissue maturation, while noting barriers such as vascularization and neural integration that hinder clinical translation.
March 2026 in “Research Square” This study developed a novel regenerative platform using nanozyme-enabled materials combined with exosomes and laser stimulation to enhance wound healing in a mouse model, which more effectively regulated reactive oxygen species and improved early angiogenesis and collagen organization compared to conventional methods.
4 citations
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December 2023 in “Advanced science” This study found that injectable gelatin/metal/tea polyphenol double nanonetworks significantly accelerated wound healing in diabetic wounds by enhancing cell migration and providing anti-inflammatory and antioxidant properties, without detectable cytotoxicity in tests.
October 2022 in “IntechOpen eBooks” This source highlights the challenges in treating cicatricial alopecia, noting that follicular unit extraction hair transplantation offers a minimally invasive and successful option to improve cosmetic outcomes for patients with permanent hair loss from scarring.
August 2014 in “Annals of Plastic Surgery” The book is a detailed guide on hair restoration, useful for both new and experienced surgeons.
This study found that a mesenchymal stromal cell-derived regenerative extracellular matrix (rECM) significantly accelerated wound closure and improved healing in diabetic mice, also enhancing nerve and blood vessel formation compared to controls.
This chapter discusses how nanotechnology, through the use of metal nanoparticles and biocompatible carriers, along with antioxidants like curcumin, quercetin, and resveratrol, offers promising approaches for treating PCOS by reducing oxidative stress and inflammation, enhancing insulin sensitivity, and normalizing hormone levels.
October 1982 in “American Journal of Nursing” Wound healing is a complex process involving different cells and stages, leading to scar tissue formation and strength increase over time.
June 2026 in “ACS Applied Materials & Interfaces” In this study, carbon dots derived from dandelion herb demonstrated significant antibacterial and biofilm-disrupting capabilities, promoting wound healing in a mouse model infected with S. aureus, while also showing excellent biocompatibility and the ability to modulate reactive oxygen species.
January 2026 in “Advanced Healthcare Materials” This study introduces a new multiaxial bioreactor system that uniformly stretches tissue-engineered skin grafts and improves skin tissue maturation through enhanced cellular distribution and environmental monitoring.
January 2013 in “Journal of Tissue Engineering and Reconstructive Surgery” This study found that inserting isolated hair follicle units into engineered dermis promoted differentiation and maturation of tissue-engineered skin, maintaining hair follicle morphology and generating skin appendages like sebaceous glands.
May 2026 in “Materials & Design” This study developed a hair-on-a-chip model that supports the maturation of hair-follicle-like tissue under long-term culture conditions, suggesting its promise for studying hair regeneration and testing scalp-targeted therapies.
15 citations
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July 2015 in “Developmental Dynamics” This study highlights the role of Orai1 in ameloblast differentiation and maturation, showing that its down-regulation affects cell proliferation and enamel formation during tooth development.
21 citations
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December 2017 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that fibroblast behavior switching between proliferation and ECM deposition is vital for dermal architecture, where cell migration is primarily important for tissue repair during wound healing.
35 citations
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October 2014 in “Wound Repair and Regeneration” This study developed a validated murine model of hypertrophic scar contraction, demonstrating similarities to human skin and observing graft contraction and tissue characteristics over time.
This study introduces a new type of tissue micromodule, the micro tissue precursor (μTP), which can form complex 3D tissues, including lung stroma and skin models supporting hair viability.
4 citations
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July 2016 in “Dermatologic Surgery” In this study, the duration of epinephrine-induced vasoconstriction in scalp tissue increased with concentration and was longer at the frontotemporal junction compared to the midfrontal area, significantly so at the highest concentration used.
87 citations
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February 2004 in “Plastic and Reconstructive Surgery” In this study, researchers achieved complete reepithelialization and hair growth on a burn-injured scalp using a tissue-engineered dermal template with early micrograft hair follicle implantation.
4 citations
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February 2011 in “Dermatology reports” In this study, oral acitretin therapy for psoriasis was associated with excess granulation tissue in the nail sulcus and noncicatricial universal alopecia.
January 2022 in “SSRN Electronic Journal” This study reports that aging in mice leads to curved hair follicles and an increase in white hairs, potentially due to changes in keratinocyte and melanocyte stem cells.
January 2023 in “Figshare” This review discusses changes in hair follicle characteristics and stem cell dynamics as indicators of aging in mice, noting increased occurrences of white hairs and curved hair follicles at older ages.
2 citations
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December 2025 in “Nano Letters” This study developed a tannin-modified cellulose-polypyrrole dressing that accelerates wound healing by enhancing granulation tissue, optimizing collagen, and stimulating angiogenesis, while providing antibacterial protection against S. aureus and E. coli.
32 citations
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January 2017 in “Orphanet journal of rare diseases” This article reviews the genetic basis, diagnostic approaches, and treatment options for nude severe combined immunodeficiency, but does not present any new research findings.
21 citations
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July 2024 in “Journal of Investigative Dermatology” This study used single-cell RNA-sequencing data from mouse skin to reveal that fibroblasts show high transcriptional plasticity during wound healing, forming transient microniches early on and stratifying scar tissue into distinct molecular layers over time.
11 citations
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March 2020 in “Immunology” This study reports that immunologically inert and skewed immune cell populations in developing human skin may contribute to wound healing and structural changes during skin development.
6 citations
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July 2017 in “Clinics in Plastic Surgery” This article reviews the management of head and neck burns across different phases but presents no new clinical results.
July 2026 in “Acta Biomaterialia” This study introduced a bioengineering platform that creates early-stage hair peg-like structures within tissue-engineered skin substitutes by integrating human keratinocytes and dermal papilla cells with laser-micropatterned collagen scaffolds, providing a foundation for future appendage-inclusive skin regeneration efforts.