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This study found that while 3D spheroid culture preserved sweat gland cell-specific markers better than 2D culture, their growth and structural organization were suboptimal, highlighting the need for improved culture systems.

The systematic review reported promising outcomes for stem cell-enriched treatments in aesthetic medicine, such as improved skin rejuvenation, hair restoration, and scar revision. However, challenges like protocol variability and regulatory issues must be addressed to ensure effective and safe clinical applications.

This study demonstrated that transplanting in vitro differentiated Wharton's jelly mesenchymal stem cells on acellular dermal grafts led to complete skin regeneration with appendages in a mouse model of full-thickness wounds.

This narrative review explores how exosomes and cell culture-conditioned media are becoming key players in the cosmetic industry for skin rejuvenation and prejuvenation, emphasizing their multifunctional topical benefits and potential future applications.

This review highlights exosomes as a promising treatment for skin damage from UV light, infrared radiation, burns, and disorders due to their anti-inflammatory properties, ability to induce macrophage polarization, and acceleration of skin repair and regeneration.

This article discusses the potential of mesenchymal stem cell-derived exosomes (MSCs-exosomes) in regenerative medicine, highlighting their beneficial effects like anti-inflammatory and tissue regeneration properties, and noting challenges such as exosome isolation and safety evaluation that need addressing.

This review highlights significant research trends and challenges in utilizing plant-derived extracellular vesicles for drug delivery and biomedical applications, emphasizing the need for standardized protocols and advanced purification technologies.

This review examines platelet-rich plasma therapy's multidisciplinary applications in regenerative medicine and discusses preparation challenges but presents no new clinical results.

This study reported that a newly developed hydrogel patch, designed to recruit regulatory T cells through ROS-triggered release of CCL22, improved wound healing and hair follicle regeneration in a diabetic mouse model by scavenging ROS, thereby protecting Tregs and suppressing Th17 cells.

This review discusses the origins, differentiation, and function of dermal fibroblasts in skin development and healing, reporting no new clinical results.

This study found that ECMs from papillary and dermal papilla fibroblasts support normal basement membrane formation, suggesting potential improvements for therapeutic biomaterials in skin engineering.

This article reviews the potential of adipose-derived and Wharton’s jelly stem cells in alopecia treatment but presents no new clinical findings, highlighting their potential benefits and limitations in regenerative medicine.

This study explored the use of manganese-doped calcium silicate nanowire-incorporated alginate hydrogels (MCSA hydrogels) for treating melanoma and promoting wound healing, finding that these hydrogels effectively ablate melanoma under near-infrared irradiation and enhance vascular endothelial cell activity for tissue regeneration.

In this study, an innovative composite hydrogel incorporating methylene blue-loaded nanoparticles was developed for 3D-printed wound dressings, showing improved mechanical properties, excellent antibacterial effects, and enhanced skin healing in mice.

This research reported that a newly developed adhesive wound dressing (SIS/PAA/LAP) demonstrated higher tissue adhesion and burst strength compared to conventional products, and improved tissue repair outcomes in animal models, suggesting potential for enhanced wound healing applications.

This study reported that a newly developed hydrogel composed of recombinant type I collagen and chitosan, incorporating a metal–polyphenol structure, demonstrated strong mechanical and healing properties, effectively promoting wound healing in a full-thickness skin defect model.

This review discusses advancements in stem cell therapy for cutaneous radiation syndrome, highlighting the potential of various stem cell sources to improve wound healing and reduce symptoms, but reports no new clinical results.

In this study, hair follicle-derived mesenchymal stromal cells showed potential for immunomodulation, with equivalent or superior responses compared to those from adipose tissue, suggesting a promising alternative cell source.

This review explores regenerative treatment options for non-scarring alopecia, with a focus on the potential of mesenchymal stem cells for hair regrowth, but it reports no new clinical results.

This study highlights that while platelet-rich plasma is showing promise across multiple medical fields like dentistry and sports medicine, a lack of standardized protocols and robust clinical trials limits its routine clinical application.

In this study, researchers developed a silk fibroin-based hydrogel with added curcumin and pluronic F127, which displayed antibacterial properties against Methicillin-resistant Staphylococcus aureus and showed potential for skin tissue regeneration, without cytotoxicity.

In this study, researchers developed a collagen and bacterial cellulose-based dressing loaded with bacitracin, which exhibited enhanced antibacterial activity, improved wound healing, and reduced inflammation in a murine infected-wound model, suggesting its potential for clinical use in treating infected wounds.

This review highlights cellulose-based materials' potential in skin disease treatments, emphasizing their smart, responsive design for various conditions, with insights into their roles in wound healing, infection prevention, and wearable monitoring.

In this study, a systematic review highlighted the potential of exosomes in cosmetics and regenerative medicine for improving skin rejuvenation and addressing aging, while also pointing out existing challenges such as regulatory hurdles and the need for more clinical validation.

This review outlines the potential of bioceramics to promote hair follicle regeneration and highlights their innovative applications for treating hair loss, emphasizing their capacity to enhance hair regrowth by releasing bioactive ions that support skin tissue repair.

This dissertation found that hair follicle transplantation promoted wound healing in mice by enhancing wound re-epithelialization and increasing nerve density in the granulation tissue.

This study found that rat hair follicle stem cells can be effectively transfected with VEGF 165 using lentivirus vectors, suggesting their potential use in developing tissue-engineered skin with improved vascularization.

This study found that a new "bead-jet" printing system for mesenchymal stem cells in Matrigel beads improved skeletal muscle regeneration and skin healing in a high-density, sparse pattern.

This study found that CLD-hFGF2 hydrogels improved healing in deep second-degree burn wounds more effectively than hydrogels alone or direct administration of CLD-hFGF2.

This study developed 3D micropatterns with magnesium silicate nanospheres that mimic vessels and hair follicles for potential use in skin regeneration by reconstructing vasculature and promoting hair growth.