165 citations
,
January 2008 in “Journal of biomaterials science. Polymer ed.” This review outlines the various processes activated by the peptide GHK-Cu in tissue remodeling and reports improvements in skin and wound healing but notes a need for further study to fully understand these mechanisms.
146 citations
,
July 2018 in “Regenerative Medicine” This review updates the understanding of fibroblast heterogeneity in wound healing, discussing advancements in fibroblast roles and potential therapies, but it reports no new clinical results.
5 citations
,
November 2020 in “Cells” The researchers reported that using a concentrate of conditioned mesenchymal stem cells derived from the placenta accelerated wound healing and regeneration in laboratory animals with severe local radiation injuries.
The study found that conditioned medium from placental cells and sub-cultured placental tissue promoted angiogenesis in HUVECs, with early pregnancy cells showing more significant effects than those from full-term pregnancy.
January 2019 in “Springer Reference Medizin” This article reviews the role of factor Xa inhibitors like Rivaroxaban and suggests they may eventually replace vitamin K antagonists, but their side effects require further clarification.
September 2014 in “Springer eBooks” This review discusses how sex hormone levels and local steroid synthesis influence gender differences in aging skin, reporting no new clinical results.
12 citations
,
April 2015 in “InTech eBooks” Platelet Rich Plasma (PRP) shows promise for tissue repair and immune response, but more research is needed to fully understand it and optimize its use.
11 citations
,
January 2000 in “Journal of Cutaneous Pathology” This paper reviews the role of the telomere-telomerase system in cellular ageing and cancer, discussing potential therapies but reporting no new experimental results.
271 citations
,
May 2019 in “Cells” This review discusses the therapeutic potential of MSC-derived secretomes for treating degenerative and inflammatory diseases, reporting no new clinical results but highlighting their proposed mechanisms and advantages over direct MSC transplantation.
773 citations
,
August 2017 in “International Journal of Molecular Sciences” This article reviews the potential advantages of secretome derivatives from human uterine cervical stem cells in MSC therapy and notes the need for regulatory standards to ensure safety and efficacy.
147 citations
,
November 2020 in “International Journal of Molecular Sciences” This review discusses the immune roles of keratinocytes in wound healing and chronic wound inflammation, emphasizing their potential impact on chronic wound pathology and highlighting areas for future research.
102 citations
,
July 2007 in “Genes & Development” This study found that maternal PPARγ is essential for preventing the production of inflammatory lipids in mouse milk, which can otherwise cause inflammation, alopecia, and growth retardation in nursing pups.
89 citations
,
January 2009 in “Advances in Clinical Chemistry” This review discusses the differences in wound healing between fetal and adult skin, highlighting the potential to uncover genes for scarless repair that could improve adult wound healing.
88 citations
,
January 2019 in “Journal of Tissue Engineering and Regenerative Medicine” This review discusses current uses and advancements in mesenchymal stem cell-derived conditioned media as a potential regenerative therapy but does not present new clinical findings.
49 citations
,
August 2007 in “Dermatologic surgery” This review discusses newer therapeutic techniques for treating postacne scarring, highlighting their effectiveness for particular grades of scars, and reports no new clinical results.
48 citations
,
March 2019 in “Frontiers in Physiology” This review discusses the typical wound healing process in skin and the oral cavity, and emphasizes the research focus on achieving scarless healing in adult skin, but reports no new clinical results.
37 citations
,
February 2019 in “Experimental Dermatology” This study explored the regenerative abilities of the African spiny mouse's skin, revealing more robust wound-induced hair follicle neogenesis compared to laboratory mice and highlighting unique features of its hair and wound response.
30 citations
,
February 2022 in “Stem Cell Reviews and Reports” This review of stem cell-based tissue engineering treatments in preclinical burn wound models reports promising improvements in skin repair, suggesting potential as an enhanced therapy for burn wounds.
27 citations
,
June 2015 in “Revista Brasileira de Farmacognosia” This review discusses the traditional uses, pharmacology, clinical applications, and toxicology of Carthami flos but reports no new clinical results, aiming to inform further research on its medicinal potential.
26 citations
,
March 2018 in “Dermatology and Therapy” This study found that conditioned media from epidermal progenitor cells improved skin aging signs in a clinical trial and protected fibroblasts from oxidative stress in vitro.
19 citations
,
May 2020 in “Cells” This study found that 5% primed conditioned medium from human umbilical cord blood-derived mesenchymal stromal cells significantly improved hair density, thickness, and growth rate in patients with androgenetic alopecia.
19 citations
,
July 2018 in “Medicines” This review highlights the pharmaceutical potential of secondary metabolites from Juniperus species, noting promising antitumor, antibacterial, and antiviral activities, but reports no new experimental findings.
18 citations
,
August 2018 in “Facial Plastic Surgery Clinics of North America” This review summarizes the positive clinical response of using platelet-rich plasma as an adjuvant in skin rejuvenation treatments, with no identifiable complications, suggesting a promising outlook for its future use.
8 citations
,
March 2018 in “Expert Review of Respiratory Medicine” This article reviews the potential of inhalation therapy to restore pulmonary elastin fibers in COPD patients and highlights the need for studies to test its feasibility; it reports no new research findings.
6 citations
,
October 2017 This review summarizes the antioxidant and anticarcinogenic properties of Indian Gooseberry, its phytochemical composition, and its use in traditional Ayurvedic medicine, but reports no new clinical results.
November 2025 in “Molecular and Cellular Biomedical Sciences” This study found no significant association between the MMP-1 gene polymorphisms rs1799750 and androgenetic alopecia in the sample population.
This review examines the potential bidirectional relationship between polycystic ovary syndrome and periodontal diseases, but reports no new clinical findings; the authors suggest further research with larger sample sizes is needed to clarify the link.
January 2019 in “Advances in stem cells and their niches” This review outlines the various fibroblast subsets in the skin dermis, their origins, and their influence on epidermal stem cell behavior, highlighting the role of the local dermal niche in stem cell plasticity.
October 2025 in “Turkish Journal of Biochemistry” This study found that patients with tropical chronic pancreatitis exhibited significantly reduced plasma amino acid levels and antioxidant capacity, with folate deficiency identified as a key factor in hyperhomocysteinemia.
76 citations
,
June 2018 in “EMBO Reports” This study demonstrates that YAP and TAZ are essential for initiating basal and squamous cell carcinomas in mice, and suggests targeting these pathways could be beneficial for treating skin cancers.