14 citations
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January 2020 in “Evidence-based Complementary and Alternative Medicine” This study found that a newly synthesized peptide from fermented Trapa japonica extract significantly promoted wound recovery and showed antiaging effects in skin cells and a clinical study, suggesting potential as a cosmetic product.
September 2023 in “Journal of microbiology and biotechnology” This study found that low molecular weight collagen peptide from fish may promote hair growth in both human cells and mice by activating the Wnt/β-catenin signaling pathway.
7 citations
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May 2023 in “Animals” This study observed that Fraser’s dolphins exhibit remarkable skin healing abilities, with type I collagen prevalent in normal skin and type III collagen emerging during early wound healing before returning to normal configuration, suggesting insights for human clinical wound management.
1 citations
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January 2008 in “Aesthetic dermatology” 3 citations
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January 2025 in “PubMed” This study compared the effectiveness of different thread types in improving collagen profiles in UVB-exposed aging model rats, finding that PCL threads were more effective than PDO and PLLA in enhancing dermal collagen characteristics.
January 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This review reports that collagen peptides provide consistent, modest benefits for skin hydration and elasticity, with variable effects on body composition and cardiometabolic risk markers, though some outcomes remain inconsistent due to trial heterogeneity.
January 2010 in “Pharmacy Today” This study found that collagen and its compound may have antioxidant effects and reduce melanin in guinea pigs, while increasing skin moisture and hydroxyproline content in mice.
January 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This review reports that collagen peptides consistently provide modest improvements in skin hydration and elasticity and varying benefits for body composition and cardiometabolic markers, although effects on blood sugar control are less consistent; variations in source, dose, and study definitions limit generalizability.
April 2023 in “Journal of Investigative Dermatology” In this study, recombinant type III collagen was found to promote fibroblast proliferation and migration, suggesting potential anti-aging and repairing effects, although it was only effective in significantly inhibiting IL-6, not TNF-α, secretion.
July 2024 in “Journal of Cosmetic Dermatology” In this clinical study, a vegan collagen builder (VEGCOL™️) was shown to safely and effectively improve hair growth, skin smoothness, wrinkle reduction, and joint pain relief in adults, with enhancements varying by dose over a 60-day period.
11 citations
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January 2015 in “Skin pharmacology and physiology” In this study, oral collagen peptides increased certain gene expressions related to epidermis development and the hair cycle in hairless mice skin, suggesting potential links to hair health.
This review reports that oral collagen peptide supplements may improve skin elasticity, hydration, and wrinkle appearance while also supporting hair and nail health and wound healing, but emphasizes the need for longer, high-quality studies due to current research limitations and variability in findings.
December 2021 in “Research Square” This study demonstrated that alkali-modified Kapok fiber significantly enhances the adsorption of collagen, suggesting its potential application in collagen-based dressings.
January 2017 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found that oral collagen peptides increased the expression of genes related to epidermal and hair cycle development in hairless mouse skin.
November 2023 in “International Journal of Pharmaceutics” This study found that a new transdermal drug delivery system using globefish skin collagen peptides and dissolving microneedles effectively promoted hair regrowth in mice with androgenetic alopecia by reducing inflammation and enhancing vascularization.
January 2015 in “Zhongguo haiyang yaowu” This study found that collagen oligopeptides from puffer skin may reduce skin melanin and increase hydroxyproline content in guinea pigs, suggesting potential skin whitening and anti-aging effects.
1 citations
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December 2025 in “International Journal of Molecular Sciences” This study reported that atelocollagen enhances collagen synthesis and reduces oxidative stress in aged skin by increasing glycine uptake through GlyT1, resulting in improved skin elasticity and collagen density in aged mice, with effects superior to glycine alone.
March 2016 in “Institutional Repositories DataBase (IRDB)” This study discusses the effects of collagen hydrolysates and the dipeptide Pro-Hyp on gene expression related to hair and epidermis development in mouse skin and reports no new clinical results.
This study found that oral collagen peptides increased expression of genes associated with epidermis development and the hair cycle in hairless mice, providing insights into their potential skin benefits.
February 2025 in “Intisari Sains Medis” This article explores the potential mechanisms by which polydeoxyribonucleotide (PDRN) could improve skin quality, slow aging, and enhance skin regeneration, but reports no new clinical findings.
May 2025 in “International Journal of Trichology” In this study, Pilopeptan® Intensive, a nutritional supplement containing hydrolyzed collagen, Group B vitamins, and zinc, was found to significantly improve hair parameters in telogen effluvium patients, with sustained benefits observed posttreatment, although mild side effects were reported by some participants.
22 citations
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May 2004 in “Tissue Engineering” This study found that collagen sponges with polyglycolic acid fibers support proper skin and hair follicle restructuring, suggesting potential usefulness for hair reconstitution research and clinical applications.
January 2026 in “International Journal of Peptide Research and Therapeutics” In this study, adults with mild-to-moderate hair damage taking GPVGPS Collagen® daily for 24 weeks showed significant improvements in hair luster, strength, thickness, and density compared to placebo, with no safety concerns reported.
8 citations
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January 2006 in “Pakistan Veterinary Journal” This study demonstrates that bacteria contribute to hair follicle neogenesis after skin wounding through IL-1R1 signaling in keratinocytes.
10 citations
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January 2024 in “Dermatology Research and Practice” This randomized, double-blind, placebo-controlled study found that a supplement containing hydrolysed collagen and vitamin C (Absolute Collagen) improved skin, scalp, and hair over 12 weeks when taken daily or every other day.
11 citations
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April 2020 in “Nutrafoods - International Journal on Nutraceuticals, Functional Foods and Novel Foods” In this study, Bioactive Collagen Peptides supplementation increased hair follicle cell proliferation and improved hair thickness in healthy women over 16 weeks compared to a placebo.
1 citations
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March 2022 in “IntechOpen eBooks” This chapter discusses various aspects of collagen, proposing "extended collagen carential disease" as a new concept tied to nutritional deficiencies, notably Vitamin C's role in maintaining collagen health.
January 2026 in “Bioengineering” In this review, various expression systems for synthesizing recombinant collagen are compared, highlighting their efficiency, modification capabilities, and cost. Key purification techniques are also analyzed, and challenges like reducing R&D costs and improving safety protocols are identified.
34 citations
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September 2020 in “Clinical, cosmetic and investigational dermatology” This research found that hyaluronic acid increased cell proliferation and type I collagen more effectively than poly-L-lactic acid in both human fibroblast cultures and rat dermis.
February 2026 in “International Journal of Science and Research (IJSR)” This study reports that salmon DNA is emerging as a promising ingredient in skincare and aesthetics, with research highlighting its potential to improve skin health and appearance through anti-aging, hydration, and regenerative properties.