71 citations
,
January 2019 in “International journal of biological sciences” This study proposes the miR-22-5p-LEF1 axis as a novel pathway that may regulate hair follicle stem cell proliferation.
69 citations
,
February 2002 in “International Journal of Cosmetic Science” This review discusses genetic and nutritional causes of hair loss, highlighting that around 90% of treated men show noticeable hair regrowth with a dual inhibitor, while women's hair loss may improve by correcting iron and l-lysine deficiencies.
67 citations
,
April 2007 in “Journal der Deutschen Dermatologischen Gesellschaft” This article reviews the development and formulation of shampoos, emphasizing their dual role as cosmetic and medicinal products, but presents no new experimental findings.
66 citations
,
February 2015 in “Cell & tissue research/Cell and tissue research” This review explores the mechanisms of hair cell death due to factors like noise, ototoxic drugs, and aging and reports no conclusive clinical results; ongoing research may eventually enable preventive treatments for hearing loss.
65 citations
,
January 2011 in “Frontiers in Endocrinology” This review summarizes the role of neurosteroids in seizure disorders and highlights the potential of neurosteroid replacement therapy in epilepsy but presents no new clinical findings.
65 citations
,
August 2007 in “Experimental Dermatology” This study found that prostaglandin metabolism enzymes are present in human hair follicles, suggesting a potential role in hair growth and differentiation, with some expression differences between men and women.
65 citations
,
September 2004 in “The American journal of pathology” This study found that overexpressing the BMP inhibitor Noggin in transgenic mice led to a significant loss of nontylotrich hair follicles, suggesting a critical role for BMP signaling in hair follicle morphogenesis and cycling.
63 citations
,
December 2002 in “Archives of Dermatology” This abstract contains no research results; it provides information about the JAMA Dermatology journal and its access options.
63 citations
,
March 2000 in “Annals of clinical psychiatry” This article reviews the association between psychopharmaceuticals and medication-induced alopecia, noting that hair regrowth typically occurs after discontinuing or reducing the medication, while mineral supplements' effectiveness remains unclear.
62 citations
,
June 2015 in “Sexually Transmitted Infections” This study identifies sexual activity as a significant potential transmission route for Trichophyton interdigitale, causing tinea genitalis among travelers to South East Asia.
61 citations
,
April 2012 in “British Journal of Dermatology” This study analyzed changes in hair diameter and density with age in Caucasian women, highlighting variations in perception of hair amount over time.
60 citations
,
December 2013 in “PLoS ONE” The researchers found that inhibiting soluble epoxide hydrolase, either genetically or pharmacologically, delayed the onset of chemically induced seizures related to GABA antagonism in experimental models.
59 citations
,
January 2002 in “Dermatology” This study suggests the existence of a new subtype of alopecia, called 'acute diffuse and total alopecia of the female scalp (ADTAFS)', characterized by acute, diffuse hair loss primarily in women and a rapid recovery.
58 citations
,
April 2017 in “The Journal of Steroid Biochemistry and Molecular Biology” This study found that patients with post-finasteride syndrome exhibited major depressive disorder, severe erectile dysfunction, and neuropathy, alongside altered neuroactive steroid levels in cerebrospinal fluid.
58 citations
,
November 2000 in “Journal of the American Veterinary Medical Association” This study reported that administering lufenuron to dogs and cats effectively and rapidly resolved fungal infections within about 21 days for dogs and 12 days for cats, compared to around 90 days in untreated controls.
56 citations
,
January 2007 in “Pharmaceutical Development and Technology” This study found that finasteride-loaded liposomal formulations achieved significantly higher skin permeation and deposition compared to conventional gels and solutions, suggesting potential for effective topical application.
55 citations
,
October 2009 in “Clinics in Plastic Surgery” Burn reconstruction improves with new techniques, materials, and tissue engineering.
54 citations
,
October 2023 in “Oncogene” In this review, the researchers detailed how the p63 transcription factor influences epithelial stem cell activities such as self-renewal, differentiation, and proliferation, highlighting the role of TAp63 and ΔNp63 isoforms in both normal tissue development and cancer pathogenesis.
54 citations
,
March 1987 in “Journal of The American Academy of Dermatology” In this study, 3% topical minoxidil showed some efficacy in hair regrowth for patients with extensive alopecia areata, especially those with less than total scalp hair loss, but did not lead to complete remission.
53 citations
,
September 2017 in “BMJ Open” This study observed that nearly all aged nursing home residents in Berlin had at least one dermatological condition, with xerosis cutis being the most common, but few associations with demographics or medical characteristics were found.
53 citations
,
January 2012 in “Fertility and Sterility” This study found that women with polycystic ovary syndrome have a higher risk for obstructive sleep apnea, primarily due to the prevalence of severe obesity, rather than the syndrome itself.
52 citations
,
May 2013 in “Supportive Care in Cancer” Scalp cooling significantly reduces hair loss in chemotherapy patients.
52 citations
,
June 1981 in “International Journal of Dermatology” Oral retinoids are effective for severe skin conditions but require careful use due to side effects.
51 citations
,
November 2013 in “Drug Discovery Today” This review discusses the potential applications and challenges of small molecules in regenerative medicine, but it reports no new research findings.
51 citations
,
July 2008 in “Dermatologic Therapy” This article proposes two new categories of cicatricial alopecia—“unstable” and “stable”—and suggests surgical excision as preferred over hair transplantation, especially for unstable cases.
50 citations
,
December 2010 in “Bjog: An International Journal Of Obstetrics And Gynaecology” This study found that Sri Lankan women with polycystic ovary syndrome experienced higher psychological distress and poorer health-related quality of life, primarily linked to hirsutism rather than obesity.
49 citations
,
May 2013 in “JAMA Dermatology” This study found that moderate to severe androgenetic alopecia is an independent predictor of increased mortality risk from diabetes mellitus and heart disease in both sexes.
48 citations
,
May 2008 in “Drug Discovery Today: Disease Mechanisms” This review discusses recent advancements in understanding hair follicles, their disorders, and potential therapeutic opportunities, but it reports no new clinical findings.
48 citations
,
July 1996 in “Human & Experimental Toxicology” Human enzymes can detoxify harmful substances but might also increase their cancer risk.
46 citations
,
August 2022 in “Journal of Endocrinological Investigation” In this study, the authors concluded that COVID-19 may not cause direct long-term harm to testicular function, but temporary indirect effects could occur, suggesting a possible delay in pursuing parenthood post-recovery.