491 citations
,
July 2000 in “The Journal of Clinical Endocrinology and Metabolism” This study found that the prevalence of polycystic ovary syndrome was 6.5% in a minimally biased sample of Caucasian women from Spain.
421 citations
,
April 2012 in “The New England Journal of Medicine” Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.
378 citations
,
September 1998 in “The Journal of Clinical Endocrinology and Metabolism” This study found that the prevalence of PCOS in a population of unselected U.S. women was 4.0%, with no significant racial differences between White and Black women.
298 citations
,
July 2000 in “The Journal of Clinical Endocrinology and Metabolism” This study found a 6.5% prevalence of polycystic ovary syndrome among a population of Caucasian women in Spain, based on specific endocrine criteria.
284 citations
,
November 1999 in “Neurology” This article discusses the side effects of interferon beta therapy for MS, including flu-like symptoms and autoimmune reactions, and provides guidance on their management but does not report new clinical findings.
165 citations
,
January 2014 in “Dermatology Research and Practice” This review discusses the various dermatological applications of zinc, including its use in treating infections, inflammatory dermatoses, pigmentary disorders, and neoplasias, and reports no new clinical findings.
135 citations
,
August 1994 in “Clinical Endocrinology” In this study of women with hirsutism or androgenic alopecia, diverse underlying endocrine disorders including polycystic ovaries and various enzyme deficiencies were detected, often associated with elevated testosterone levels.
107 citations
,
September 2002 in “Journal of Investigative Dermatology” This study identified a distinct "exogen" phase in the hair cycle during which hair shedding occurs, primarily coupled with the anagen phase, rather than as part of the telogen phase.
90 citations
,
October 1983 in “British Journal of Dermatology” This study found that individuals with androgenic alopecia have an increased number of thin hairs (less than 40 microns in diameter) per cm², which may affect their clinical appearance.
86 citations
,
October 2017 in “Translational pediatrics” This review discusses how ophthalmic findings can reveal key endocrine disorders and reports no new clinical results, emphasizing the eye's role in diagnosing and managing systemic diseases like diabetes and Graves' ophthalmopathy.
84 citations
,
November 2003 in “European journal of endocrinology” This study found that women with androgenic alopecia had a higher prevalence of polycystic ovarian morphology and higher androgen levels compared to controls, suggesting a strong association with PCO.
78 citations
,
November 2008 in “Fertility and Sterility” Amenorrhea is relatively rare and initial testing should check FSH, TSH, and prolactin levels.
77 citations
,
June 2017 in “Advances in Therapy” This review discusses recent advances and ongoing clinical trials in novel therapeutics for alopecia areata, despite the lack of current FDA-approved treatments for severe cases, and reports no new results.
76 citations
,
May 2007 in “Menopause International” This review discusses the relationship between estrogen deficiency and skin aging in postmenopausal women, noting potential benefits of estrogen use on skin collagen and elasticity, but reports no new clinical results.
75 citations
,
November 1996 in “Fertility and Sterility” This study found that finasteride effectively reduced hirsutism in women during 12 months of treatment, with some effects persisting in the majority after stopping the medication.
71 citations
,
January 2015 in “The Scientific World Journal” This review discusses the link between insulin resistance and skin conditions such as acanthosis nigricans and psoriasis, but provides no new clinical results.
68 citations
,
September 2003 in “British Journal of Dermatology” This study found that in thin cutaneous melanomas, tumor regression is associated with a higher risk of sentinel lymph node involvement.
68 citations
,
May 2021 in “Endocrine” This review discusses the emerging "endocrine phenotype" of COVID-19, highlighting the implications for managing diabetes, obesity, vitamin D deficiency, and other endocrine conditions in affected patients.
66 citations
,
September 2008 in “Dermatologic therapy” This review discusses medical treatments for hirsutism, focusing on oral contraceptives and other therapies, but reports no new results; the authors emphasize the lack of evidence for insulin sensitizers in treating hirsutism alone.
54 citations
,
April 2010 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism” This review discusses 46,XY disorders of sex development caused by defects in androgen production and highlights the need for long-term care from experienced multidisciplinary teams, but it reports no new clinical findings.
49 citations
,
February 2019 in “The Journal of Clinical Endocrinology and Metabolism” This review offers evidence-based recommendations for diagnosing and treating female pattern hair loss, emphasizing clinical assessment and starting treatment with minoxidil, while noting that measurement of certain hormones and vitamins is optional.
46 citations
,
January 1996 in “Journal of The American Academy of Dermatology” This study identified the presence of apoptotic or necrotic keratinocytes and hair shaft dystrophy as potential markers of hair loss in patients with HIV-1 infection.
45 citations
,
March 2010 in “Journal der Deutschen Dermatologischen Gesellschaft” This article discusses methods for diagnosing and managing diffuse hair loss and reports no new results; the authors emphasize systematic evaluation and the importance of psychological support.
42 citations
,
July 2015 in “Cosmetics” This review discusses the use of cosmetic nanocarriers to improve hair appearance and reports no new experimental results.
42 citations
,
August 1999 in “The American journal of pathology” This study found that basal cell carcinomas show strong expression of vitamin D receptors at both mRNA and protein levels, suggesting a potential role in tumor growth regulation.
42 citations
,
January 2006 in “Obstetrical & Gynecological Survey” This article discusses the importance of recognizing and distinguishing polycystic ovary syndrome from similar endocrine disorders, and reports no new clinical results.
40 citations
,
November 2009 in “Experimental Dermatology” This review discusses the role of the mineralocorticoid receptor in skin biology, highlighting its potential involvement in keratinocyte and hair physiology, and proposes it may affect the side effects of glucocorticoid use.
39 citations
,
October 2013 in “Plastic and Reconstructive Surgery” In this study, researchers found that intestine-derived human alpha defensin 5 enhances wound healing, reduces bacterial load, and promotes hair growth in murine burn wound beds by increasing LGR stem cell migration.
38 citations
,
May 2006 in “Archives of Gynecology and Obstetrics” This study reported that women with PCOS had higher levels of certain hormones and lower SHBG levels compared to non-PCOS women with similar symptoms, highlighting a less favorable endocrine profile in PCOS cases.
36 citations
,
November 2000 in “Journal of the American Academy of Dermatology” This case study describes a unique patient with dermatomyositis who exhibited features of pityriasis rubra pilaris and porokeratosis, suggesting markers for malignancy warranting thorough investigation and monitoring.