291 citations
,
April 2010 in “Gastroenterology” This study identified Lgr5 and Lgr6 as receptors expressed by small populations of stem cells in various adult organs, with Lgr5+ve cells forming long-lived organoids in certain mouse models.
286 citations
,
January 2009 in “Human Reproduction Update” This study reports that NIH PCOS is linked to more severe metabolic issues, including higher obesity and insulin resistance, compared to non-NIH PCOS phenotypes.
237 citations
,
January 2010 in “The Journal of Sexual Medicine” The authors updated recommendations on diagnosing and treating women's sexual dysfunctions, emphasizing a comprehensive assessment approach, while noting the need for further multidisciplinary research.
100 citations
,
June 2002 in “Diabetologia” This study found that parents of women with PCOS have a higher prevalence of insulin resistance and Type II diabetes than parents of healthy women.
91 citations
,
May 2005 in “The Journal of Clinical Endocrinology & Metabolism” In this study, a novel mutation in the glucocorticoid receptor gene was identified in a young woman, impairing glucocorticoid signaling and leading to generalized glucocorticoid resistance.
70 citations
,
March 2016 in “Urologic Clinics of North America” This article reviews the coordination of the hypothalamic-pituitary-gonadal axis, male fertility, and therapies for hypogonadism, but reports no new clinical findings.
69 citations
,
November 2010 in “Middle East Fertility Society Journal” This review discusses the multifactorial origins and pathophysiology of PCOS and highlights the effectiveness of lifestyle modifications as a first-line intervention, reporting no new research results.
67 citations
,
July 2016 in “Reviews in Endocrine and Metabolic Disorders” This review discusses the complex relationship between stress and various skin conditions, highlighting the role of the skin in the stress response and the brain-skin communication pathways, but reports no new research findings.
66 citations
,
January 2001 in “Vitamins and hormones” This chapter reviews the role of androgen receptors in mediating the actions of androgens in specific tissues and provides no new experimental findings.
64 citations
,
January 2010 in “The FASEB Journal” This study found that prolactin is a key regulator of keratin expression in human hair follicles, enhancing specific keratin types and influencing epithelial stem cell-associated keratins.
53 citations
,
December 2015 in “JAMA Dermatology” This study found that hirsutism and acanthosis nigricans are the most reliable skin markers for diagnosing polycystic ovary syndrome in women and suggest a need for further evaluation of possible metabolic issues.
47 citations
,
August 2000 in “Endocrine Reviews” This review discusses idiopathic hirsutism, potential underlying mechanisms, and various therapeutic approaches without providing new clinical results, and emphasizes the need for further research on well-defined patient groups.
40 citations
,
January 2010 in “Annales D Endocrinologie” This article discusses diagnostic guidelines for PCOS, emphasizing the use of the Rotterdam criteria and recommending clomiphene citrate as the first-line treatment for ovulation induction; it reports no new clinical results.
34 citations
,
October 2017 in “Archivos Argentinos De Pediatria” This review discusses the clinical characteristics, diagnosis, and treatment of alopecia areata, exploring potential environmental, immunological, and genetic factors involved in its development, but reports no new research findings.
26 citations
,
April 1984 in “The American Journal of Surgery” This study found that gastric exclusion surgery in morbidly obese patients resulted in significant weight loss, improved metabolic parameters, and reduced prevalence of hypertension, diabetes, gout, and hyperlipidemia over time.
24 citations
,
July 2012 in “Current Opinion in Obstetrics & Gynecology” This review discusses the diagnostic criteria and treatment options for adolescent polycystic ovary syndrome, highlighting ongoing debates and the need for further research, without presenting new clinical results.
12 citations
,
January 2011 in “Dermatologic Surgery” This entry contains only a placeholder abstract with no research findings described or summarized.
5 citations
,
February 2019 in “PloS one” This study found that structural defects in the hair shafts of sighthounds with bald thigh syndrome are related to a downregulation of genes and proteins essential for hair shaft formation.
4 citations
,
December 2020 in “Dermatologic Therapy” This study reports a case of Ellis van Creveld syndrome in a 40-year-old Iranian woman, highlighting uncommon features such as pectus excavatum, Phrygian cap gallbladder, liver hemangioma, polycystic ovarian disease, and breast fibrocystic cysts.
3 citations
,
June 2017 in “Methods” This study used computational modeling to identify key genes and miRs involved in cardiac aging, finding a strong relationship supported by literature and some experimental validation in aged mouse hearts.
2 citations
,
January 2013 in “Elsevier eBooks” This chapter reviews the causes and underlying steroid pathways of hirsutism and virilization in women, detailing relevant conditions and laboratory assays without reporting new clinical results.
2 citations
,
November 2012 in “InTech eBooks” The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.
2 citations
,
September 2002 in “Journal of Endocrinological Investigation” The GH-IGF-I axis is likely involved in the hormonal imbalances seen in non-obese women with functional hyperandrogenism.
1 citations
,
August 2023 in “Cutis” This review discusses the role of ferritin in iron homeostasis and its potential utility in diagnosing iron deficiency as a cause of hair loss, while noting that ferritin's impact on skin and hair disorders is not fully understood.
1 citations
,
May 2023 in “Indian Journal of Dermatology Venereology and Leprology” This study found that patients with alopecia areata were more likely to experience hearing loss compared to healthy individuals, potentially due to damage to follicular melanocytes involved in the autoimmune process.
1 citations
,
January 2015 in “Journal of Pigmentary Disorders” This review discusses the complex relationship between melasma and factors like female sex hormones, genetics, and ultraviolet light exposure, but reports no new clinical findings.
1 citations
,
January 2015 in “Advanced techniques in biology & medicine” This study found that among patients with Down syndrome, those with alopecia areata may have increased antiperoxidase antibodies, possibly linked to hypothyroidism.
September 2022 in “Curēus” This case report describes a 61-year-old female with hyperandrogenic symptoms, where an ovarian hemangioma with stromal luteinization was identified and surgically removed, resulting in improved symptoms.
January 2022 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)” This article presents an overview of uncombable hair syndrome, emphasizing its clinical and molecular characteristics and noting systemic manifestations such as neuropsychiatric, ophthalmic, and cardiopulmonary issues.
This review discusses the diagnostic criteria and management challenges for polycystic ovarian syndrome and reports no clinical results, highlighting complications associated with pregnancy in women with the condition.