29 citations
,
March 2011 in “The Journal of Nutritional Biochemistry” Eating isoflavone can help mice grow hair by increasing a growth factor.
29 citations
,
March 2001 in “Clinics in Dermatology” This article discusses various types of primary cicatricial alopecias and reports no new clinical results; it emphasizes the importance of accurate diagnosis for effective management.
28 citations
,
January 2017 in “Critical Reviews in Therapeutic Drug Carrier Systems” This review classifies engineered nanomaterials by composition and application in biomedicine, highlighting diverse uses like regenerative medicine and potential occupational side effects, but reports no new clinical results.
27 citations
,
May 2017 in “Marine Drugs” This study found that Undariopsis peterseniana extract may promote hair growth by activating specific cellular pathways, suggesting potential for treating alopecia.
27 citations
,
September 2014 in “JAMA dermatology” In this NIH study, female donor to male recipient sex mismatch was significantly associated with the development of vitiligo and/or alopecia areata in patients with chronic graft-vs-host disease.
27 citations
,
January 2012 in “Current Topics in Microbiology and Immunology” This study found similarities in the regeneration processes of MRL mouse ears and axolotl limbs, involving G2 cell cycle arrest and nerve-dependent mitosis, but the role of p21 in axolotl limb regeneration remains uncertain.
27 citations
,
January 2006 in “Colloids and Surfaces B: Biointerfaces” This study found that in vitro, cultured bulge cells from human hair follicles possess properties of primitive cells, supporting the hypothesis that hair follicle stem cells reside in the bulge area.
26 citations
,
January 2013 in “BioMed Research International” This review discusses the hormonal influences on hair cycling disorders in post-partum and postmenopausal women and notes the lack of evidence for effective targeted treatments.
26 citations
,
July 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects” This review discusses the identification and roles of different epidermal stem cell types in skin homeostasis and repair, and reports no new experimental findings.
26 citations
,
November 2002 in “Planta medica” In this study, the methanol extract of Cercidiphyllum japonicum heartwood was found to stimulate the proliferation of mouse hair epithelial cells, with several isolated compounds showing significant proliferative activities.
26 citations
,
March 1986 in “Clinical and Experimental Dermatology” Scalp hair grows at 0.37 mm/day, forearm hair at 0.18 mm/day, and thigh hair at 0.30 mm/day, with no significant differences found in people with certain hair conditions.
25 citations
,
March 2019 in “Dermatologic therapy” This study reviewed the current state of intralesional therapy for keratoacanthoma, finding that while methotrexate, 5-fluorouracil, and interferon alpha are common agents, guidelines are still needed, and histopathological confirmation is advised to prevent misdiagnosis with squamous cell carcinoma.
25 citations
,
November 2017 in “Molecular Medicine Reports” This study found that PlncRNA‑1 may enhance the proliferation and differentiation of hair follicle stem cells by upregulating the TGF‑β1-mediated Wnt/β-catenin signaling pathway.
25 citations
,
December 1992 in “Seminars in cell biology” This review discusses how epidermal Langerhan's cells and dermal cells may influence keratinocyte environments, potentially aiding in the formation of stem cell niches and cellular variety in the basal layer, without providing novel results.
24 citations
,
January 2015 in “Annals of Dermatology” In this study, herbal extracts commonly used in traditional medicine were observed to significantly increase the proliferation of human dermal papilla cells, suggesting potential as alternative therapies for enhancing hair growth.
23 citations
,
January 2022 in “Biomaterials Science” Non-viral vectors show promise for safe and effective CRISPR/Cas9 gene editing in treating diseases.
23 citations
,
August 2018 in “Facial Plastic Surgery Clinics of North America” This review discusses the role of defensin peptides in stem cell activation for potential skin rejuvenation therapies and reports no new clinical findings, emphasizing the need for further studies.
23 citations
,
May 2013 in “Virology” This study found that HPV16 oncogene expression in multipotent epithelial stem cells led to abnormal mobilization, altering their quiescence without affecting other stem cell markers, suggesting a distinct stem cell compartment.
23 citations
,
July 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that follicular stem cells in hair follicles are more sensitive to the antiproliferative effects of glucocorticoids compared to basal keratinocytes due to incomplete desensitization.
23 citations
,
January 2001 in “International journal of toxicology” This review discusses the cosmetic use and safety of Hypericum Perforatum Extract and Oil, finding that current data are insufficient to support their safety in formulations due to a lack of comprehensive testing.
22 citations
,
November 2017 in “Scientific Reports” This study found that, despite a major depletion of SOX2-expressing stem cells in the pituitary, there was no effect on endocrine cell homeostasis or response to certain stressors in adult mice.
22 citations
,
June 2013 in “International journal of molecular sciences” This review discusses the mechanisms governing epidermal stem and progenitor cell differentiation, emphasizing the balance necessary for maintaining skin barrier function, and reports no new experimental findings.
22 citations
,
November 2012 in “Journal of cosmetic dermatology” This review outlines the processes and potential of stem cells in regenerating skin, hair, and other tissues but presents no new experimental findings.
21 citations
,
February 2017 in “PLoS ONE” This study found that RhoA influences embryonic stem cell proliferation through the PKN1-cyclin D1 pathway in vitro, suggesting RhoA as a potential target for wound healing therapies.
21 citations
,
January 2015 in “The Journal of Steroid Biochemistry and Molecular Biology” In this study, researchers demonstrated that in a mouse model, the stimulation of mammary tumor growth due to progesterone is primarily caused by its metabolite, 5αP, not progesterone itself.
21 citations
,
October 1988 in “Clinics in Dermatology” This study found that topical minoxidil induced hair regrowth in stumptailed macaques, with more significant effects observed in younger animals, while cessation led to renewed balding and retreatment restored regrowth.
20 citations
,
January 2017 in “Nutrition Research and Practice” In this study, corn silk extract treatment improved symptoms of testosterone-induced BPH by reducing specific mRNA expression and decreasing levels of 5α-R2, DHT, and PSA.
20 citations
,
September 1978 in “International Journal of Dermatology” Hair growth is influenced by factors like genetics and nutrition, and more research is needed to understand hair loss and growth mechanisms.
19 citations
,
April 2019 in “Journal of the European Academy of Dermatology and Venereology” This study found that acne lesion formation involves early hyperkeratinization and inflammation around hair follicles, creating a self-sustaining cycle that may progressively worsen acne.
19 citations
,
January 2015 in “Current problems in dermatology” This review discusses environmental factors like UV radiation and smoking that affect hair health and highlights the potential role of nutrition, but it reports no new results.