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Using CDK inhibitors on rats showed a reduction in chemotherapy-caused hair loss, but later experiments could not repeat these results.

Minoxidil treats hair loss, promotes growth, has side effects, and has recent patents.

Silver can help prevent and treat infections but its effectiveness varies and should be weighed against costs and side effects.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Minoxidil boosts hair growth by increasing cell production and survival.

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

Too much Smad7 changes skin and hair development by breaking down a protein called β-catenin, leading to more oil glands and fewer hair follicles.

Cathepsin L is essential for normal hair growth and development.

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

RNAi-based biopesticides could be safe and effective for pest control with careful development and risk assessment.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

Nanoparticles can improve skin drug delivery but have challenges like toxicity and stability that need more research.

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Fat cells in the skin help start healing and form important repair cells after injury.

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

Dexamethasone speeds up hair loss in mice, while cyclosporin A slows it down.

IL-2 treatment causes skin eruptions and other reversible side effects, and may play a role in psoriasis.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

No single treatment is consistently effective for alopecia areata, and more research is needed.