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Stem cell niches support, regulate, and coordinate stem cell functions.

Women with PCOS face higher risks of diabetes and heart disease, and these risks increase with obesity.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Memory T cells in the skin balance staying put and moving into the blood, clustering around hair follicles, and increasing in number after infection.

Stem cell self-renewal is complex and needs more research for full understanding.

The dermal papilla is crucial for hair growth and health, and understanding it could lead to new hair loss treatments.

Patients with certain skin symptoms and high ANA titers should be monitored for potential systemic lupus.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

Masculine facial features may not reliably indicate heritable health, and more research is needed.

The document recommends using both clinical evaluation and various measurement methods to assess skin greasiness, considering factors like temperature and hormones.

Different types of stem cells and their environments are key to skin repair and maintenance.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

Obesity is linked to various skin problems and may increase the risk of skin cancer.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Fat cells in the skin help start healing and form important repair cells after injury.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Testosterone's muscle-building effects do not require its conversion to DHT.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

Male hormones like testosterone may make COVID-19 worse, and testing for sensitivity to these hormones could help predict how severe a patient's symptoms might be. Treatments that reduce these hormones are being explored.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Potassium channel openers could help treat cardiovascular diseases and asthma but require better targeting to specific tissues for effective use.

Children with atopic dermatitis often have sleep problems, affecting their growth and behavior.

Some drugs can cause skin, nail, and hair problems, which are important for healthcare professionals to recognize and report.