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Apple polyphenol, especially oligomeric procyanidins, can reduce fat absorption and lower blood fat levels.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

Ruxolitinib effectively regrows hair in most patients with severe hair loss.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Blood vessels and specific genes help turn cartilage into bone when bones heal.

Blocking JAK-STAT signaling can lead to hair growth.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Memory T cells in the skin balance staying put and moving into the blood, clustering around hair follicles, and increasing in number after infection.

Peptide hydrogels heal burn wounds faster and better than standard dressings.

Pig skin is a good substitute for human skin to measure drug absorption, but differences in skin structure and enzymes across species must be considered.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Hair follicles may soon be used more for targeted and systemic drug delivery.

Periodontal ligament stem cells show promise for regrowing tissues but require more research for safe, effective use.

Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.

Different types of stem cells and their environments are key to skin repair and maintenance.

The document concludes that specific cells are essential for hair growth and more research is needed to understand how to maintain their hair-inducing properties.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

Skin surface lipids are important for skin health and altering them could help prevent aging and treat skin conditions.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.