This trial will compare the effectiveness of spironolactone to doxycycline for treating acne in adult females, potentially offering an alternative to antibiotics and isotretinoin.
This trial explores whether spironolactone is more effective than cyclines for treating moderate acne in adult women, providing a potential alternative amidst concerns over antibiotic resistance.
May 2015 in “UC Merced Undergraduate Research Journal” This review suggests that while both pharmaceuticals and behavioral therapies can reduce symptoms of trichotillomania, behavioral therapies often prove more effective, though long-term effectiveness remains uncertain.
January 2012 in “Jounal of The Korean Society of cosmetology” Applying conditioner mid-treatment reduces hair damage during perms.
January 2011 in “Liaoning Zhongyiyao Daxue xuebao” This study found that Chinese medicine treatment "Tonifying Kidney and Removing toxins" significantly improved clinical symptoms and reduced disease activity in patients with systemic lupus erythematosus compared to controls.
November 2006 in “Yafteh” This study found that an herbal drug reduced the duration of telogen effluvium more effectively than minoxidil in patients.
July 2020 in “Journal of Tissue Engineering and Reconstructive Surgery” February 2019 in “DOAJ (DOAJ: Directory of Open Access Journals)” This meta-analysis reported that dutasteride was more effective than finasteride in increasing hair count and improving visual hair appearance in men with androgenetic alopecia over a 24-week period, while both drugs had similar rates of sexual dysfunction side effects.
November 2016 in “Cochrane Clinical Answers”
59 citations
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October 2012 in “Pharmaceutical Research” This study found that nanostructured lipid carriers with more soybean phosphatidylcholine provided better skin retention and follicular targeting for diphencyprone compared to other formulations and controls.
26 citations
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January 2012 in “Journal of the American Academy of Dermatology” This study found that adding topical eflornithine to hair laser treatment significantly reduced hair counts and inflammatory papules more effectively than laser therapy alone in treating pseudofolliculitis barbae.
25 citations
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June 2018 in “Clinical and Experimental Dermatology” This study found that combining fractional radiofrequency microneedling with 5% topical minoxidil improved hair count and thickness more than minoxidil alone in Chinese men with male pattern hair loss.
24 citations
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November 2017 in “Aesthetic Plastic Surgery” In this study, researchers found that homologous PRP (h-PRP) significantly increased hair density more than both nonactivated (n-PRP) and activated (a-PRP) autologous PRP in patients with androgenetic alopecia, suggesting h-PRP as a potentially more effective treatment option for hair loss.
22 citations
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September 2024 in “Chemical Engineering Journal” A new microneedle patch effectively and safely treats alopecia areata.
10 citations
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May 2020 in “Journal of Dermatological Treatment” This study found that combining microneedling with 5% minoxidil improved hair growth in Chinese men with androgenetic alopecia, possibly through activating the Wnt/β-catenin signaling pathway.
9 citations
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June 2020 in “Trials” This study aims to conduct the first double-blind randomized trial comparing spironolactone and doxycycline for female acne treatment, with the goal of establishing spironolactone as a potentially superior alternative, especially given concerns about antibiotic resistance.
5 citations
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September 2017 in “Journal of Cosmetic Dermatology” This review of clinical data found that an oral marine supplement increased hair growth and thickness while reducing hair loss in women and men with thinning hair, suggesting it is a safe and effective treatment.
3 citations
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June 2025 in “Journal of Cosmetic Dermatology” Using combined fat and growth factors can effectively treat hair loss after facial fillers.
2 citations
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January 2020 in “Tropical Journal of Pharmaceutical Research” This review discusses the extensive variety of traditional Chinese medicine preparations used for treating hair loss, primarily consisting of botanical materials, but reports no new clinical results.
2 citations
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May 2012 in “Indian drugs” This study found that a proniosomal gel formulation of finasteride increased anagen hair count in male volunteers with androgenic alopecia by 42.85% compared to the control group.
August 2026 in “European Journal of Pharmacology” July 2026 in “Journal of Craniofacial Surgery” This study found that silencing SRD5A2 and applying melatonin significantly boosted proliferation and migration of human hair follicle stem cells without causing differentiation, while increasing MT1 expression and reducing 5-alpha-reductase levels.
February 2026 in “PubMed” This study found that among women with female pattern hair loss, low-dose oral minoxidil improved hair loss severity and quality of life scores despite 71.6% experiencing mild to moderate unwanted hair growth, which most patients did not consider a reason to discontinue treatment.
February 2026 in “Journal of Cosmetic Dermatology” In this study, researchers found that combining cryotherapy with triamcinolone injections is equally effective as triamcinolone alone for treating patchy alopecia areata on the scalp and face, with no significant difference in outcomes between the two methods.
January 2026 in “Figshare” In this study, women with female pattern hair loss using low-dose oral minoxidil reported significant improvements in hair loss severity and quality of life, with most experiencing mild or moderate unwanted hair growth but continuing treatment regardless.
January 2026 in “Figshare” This study found that women with female pattern hair loss experienced improvements in hair loss severity and quality of life from low-dose oral minoxidil use, despite a common side effect of unwanted hair growth, which most did not consider a reason to stop treatment.
December 2025 in “Cureus” This article discusses topical keratolytic therapy for keratosis pilaris, highlighting potential benefits while noting limitations in the current evidence base, and reports no clinical results.
October 2025 in “JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH” This study found that both single spin and double spin techniques of PRP preparation significantly improved hair growth in male androgenetic alopecia, with no statistical difference between the methods.
July 2025 in “Skin Health and Disease” This study concluded that platelet-rich plasma is nearly as effective as topical minoxidil for treating androgenetic alopecia, with PRP improving hair density and minoxidil boosting terminal hair count.
In this preclinical study, PA-011 derived from Periplaneta americana showed significant hair regrowth effects in androgenetic alopecia mouse models by inhibiting inflammation and oxidative stress, activating hair follicle stem cell proliferation, and normalizing skin microbiota, suggesting promise as an AGA treatment.