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Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Mitochondrial dysfunction is linked to various skin conditions and could be a target for treatments.

Paris polyphylla saponins may effectively treat acne due to their antibacterial and anti-inflammatory properties.

Free fatty acids in sebum boost skin's defense against acne by increasing antimicrobial peptides.

Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.

Essential oils from Curcuma species, like turmeric, have compounds that can fight inflammation, cancer, and bacteria, and can also stimulate hair regrowth in bald males.

Algerian Carthamus caeruleus L plant has anti-inflammatory properties, heals wounds effectively, and may help with hair growth.

The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.

Wnt5a may contribute to psoriasis by reducing skin cell growth, blocking skin cell maturation, and increasing inflammation.

Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.

Formyl-peptide receptor agonists could be new anti-inflammatory drugs.

The gel with icariin speeds up wound healing, reduces scarring, and helps hair growth by controlling BMP4 signaling. It also reduces inflammation and improves wound quality in mice, adapts to different wound shapes, and gradually releases icariin to aid healing. It also prevents too much collagen and myofibroblast formation during skin healing.

Melatonin may protect inner ear cells from damage by reducing cell death and oxidative stress, potentially treating sudden hearing loss.

Vitamin D made by the skin plays a role in immune defense and skin health, and more research is needed to understand its full effects.

MicroRNAs are important for skin health and could be targets for new skin disorder treatments.

Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.

The vitamin D receptor can act without its usual activating molecule, affecting hair growth and skin cancer, but its full range of actions is not well understood.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Keratin treatment reduces astrocyte reactivity and inflammation.

Bioassays help find useful compounds in nature for making medicines, supplements, and cosmetics.

Allopregnanolone increases growth and changes gene activity in human brain cancer cells.

Hair papilla cells are crucial for blood vessel development in hair follicles, affecting hair growth and loss.

Some hormone-related drugs may protect brain cells in Parkinson's disease differently in men and women.

FGF21 can help reduce skin inflammation caused by C. acnes.

Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.

Found different proteins in balding and non-balding cells, giving insight into hair loss causes.

GSK-36 downregulation with UTMD improves plaque stability in atherosclerosis treatment.

MOF controls skin development by regulating genes for mitochondria and cilia.

Plumbagin may help protect cells, reduce inflammation, and has potential for treating various diseases, but more research is needed.

Skin cells release substances important for healing and fighting infection, and understanding these could improve skin disorder treatments.