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    Glossary Thioglycolic Acid

    chemical used in hair treatments to break disulfide bonds

    Thioglycolic Acid, also known as TGA, is a chemical compound commonly used in hair care products, particularly in hair perming and straightening treatments. It works by breaking the disulfide bonds in hair proteins, allowing the hair to be reshaped. This compound is also used in depilatory creams to remove unwanted hair by weakening the hair structure.

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    Research 30 of 84

    1. A Survey on Health Effects in a Human Population Exposed to Permanent‐Waving Solution Containing Thioglycolic Acid Journal of Occupational Health · 2003 · 31 citations
    2. Action of Thioglycolic Acid and L-Cysteine to Disulfide Cross-Links in Hair Fibers during Permanent Waving Treatment Sen'i Gakkaishi · 2008 · 18 citations
    3. The location of the thioglycolic acid molecules in intrafibrillar unordered areas of the human hair keratin structure International Journal of Cosmetic Science · 2012 · 10 citations
    4. Chemical Reactions Occurring in Curing Treatment for Permanent Hair Straightening Using Thioglycolic and Dithioglycolic Acids Sen'i Gakkaishi · 2009 · 3 citations
    5. Reproduction Mechanism of SS Cross-Links in Permed Hair by the Washing after Reduction with Thioglycolic Acid Sen'i Gakkaishi · 2015 · 2 citations
    6. Intermolecular disulfide cross-linked structural change induced by permanent wave treatment of human hair with thioglycolic acid. PubMed · 2013 · 1 citations
    7. Assessment on the Effects of Liposome-encapsulated Thioglycolic Acid on Hair Perming Sen i Gakkaishi · 2014
    8. Keratin film made of human hair as a nail plate model for studying drug permeation European Journal of Pharmaceutics and Biopharmaceutics · 2011 · 68 citations
    9. Analysis of heterogeneous reaction between reducing agents and keratin fibers using Raman spectroscopy and microspectrophotometry Journal of molecular structure · 2012 · 20 citations
    10. Histochemical observation of the cell membrane complex of hair. Sen'i Gakkaishi · 1992 · 15 citations
    11. A Raman spectroscopic investigation of the mechanism of the reduction in hair with thioglycerol and the accompanying disulphide conformational changes International Journal of Cosmetic Science · 2017 · 13 citations
    12. Preparation of Water Soluble Wool Keratin and Its Application for Human Hair Transactions of the Materials Research Society of Japan · 2009 · 8 citations
    13. Green chemistry method for hair strengthening and setting using visible light-mediated protein crosslinking Journal of cleaner production · 2022 · 4 citations
    14. Effects of permanent waving on changes of protein and physicomorphological properties in human head hair. PubMed · 2008 · 3 citations
    15. Effects of Thioglycolate Compounds in an Emerging Technique in the World of Cosmetics—Brow Lamination Journal of Cosmetic Dermatology · 2024 · 2 citations
    16. Cytotoxic Evaluation of Hair Relaxers and Straighteners Actives in Human-Derived Skin Cells Preprints.org · 2021 · 1 citations
    17. Reconnection of cysteine in reduced hair with alkylene dimaleates via thiol‐Michael click chemistry International Journal of Cosmetic Science · 2024
    18. Let’s not split hairs Nature Reviews Chemistry · 2023
    19. Permanent Hair Waving Cosmetic Dermatology · 2022
    20. Direct Observation of Hair Components Involved in Formation of Permanent Waves Sen'i Gakkaishi · 2013
    21. Preparation and Characterization of Soluble Wool Keratin for Human Hair Care Transactions of the Materials Research Society of Japan · 2013
    22. Enzymatic approach to analyze the effects of mercaptans on hair International Journal of Cosmetic Science · 2010
    23. J. Cosmet. Sci., 59, 203-215 (May/June 2008) �Effects of permanent waving on changes of protein and physicomorphological properties in human head hair International Journal of Cosmetic Science · 2009
    24. Hair Preparations Kirk-Othmer Encyclopedia of Chemical Technology · 2000
    25. Folklore Herbal Plants as a Safe and Natural Hair Depilatories Journal of pharmaceutical research international · 2021
    26. Structural Changes of Hair Keratin by Reduction, Heat and subsequent Oxidation Treatments Sen i Gakkaishi · 2004 · 3 citations
    27. Poly(γ-Glutamic Acid)/Chitosan Hydrogel Nanoparticles For Effective Preservation And Delivery Of Fermented Herbal Extract For Enlarging Hair Bulb And Enhancing Hair Growth International Journal of Nanomedicine · 2019 · 22 citations
    28. A novel purification procedure for keratin-associated proteins and keratin from human hair Journal of Biological Macromolecules · 2013 · 54 citations
    29. Amino Acid Content of Damaged Human Hair 1981 · 2 citations
    30. Synthesis of a new amino acid derivative with long‐lasting hair shape control effects and elucidation of its mechanisms International Journal of Cosmetic Science · 2025