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In this study, researchers isolated and identified diverse endophytes from plants in Asia, finding that these microorganisms have significant potential for producing useful metabolites, including enzymes and antibiotics.

This study showed that Thujae occidentalis semen extract inhibited 5alpha-reductase type 2 in laboratory tests and reduced androgen-related hair loss in animal models, suggesting potential use for male pattern baldness.

This study found that SRD5a-3 is a highly efficient enzyme for converting hormones into androgens, with dutasteride being a much more potent inhibitor of SRD5a-3 than SRD5a-2.

This study found that sebaceous glands predominantly exhibit oxidative activity of the type 2 17β-hydroxysteroid dehydrogenase isozyme, which is not inhibited by 13-cis retinoic acid.

In this study, germacrone from Curcuma aeruginosa showed anti-androgenic effects by inhibiting 5α-reductase, suggesting its potential as a lead compound for treating androgen-dependent disorders.

This study found that long-term flutamide treatment reduced hair loss in women with female pattern hair loss, but liver-related dropouts were minimized at a very low dose of 62.5 mg/day.

This study found that androgen metabolism within hair follicles varies significantly between compartments, with dermal papillae showing high 5α-reductase activity, suggesting a key role in androgen-driven hair growth responses.

This study revealed that deficiency in the enzyme FA2H in mice affected sebaceous gland function, altered sebum composition, and caused cycling alopecia, highlighting FA2H's role in hair follicle homeostasis.

This study found that overexpressing PLC5 in Arabidopsis thaliana reduced root growth but improved drought tolerance, and suggests PIP2 is crucial for root hair growth.

This study suggests that in SZ95 sebocytes, a pathway for DHT biosynthesis does not require testosterone as an intermediate, potentially impacting the treatment of androgen-sensitive skin conditions.

This study found that alkaloids isolated from Eclipta alba leaves showed increasing antimicrobial activity with higher concentrations, particularly against S. aureus and E. coli, suggesting potential for developing antimicrobial agents.

This review summarized multiple molecular markers studied for their association with dry skin, finding considerable variability and uncertainty about which markers best indicate xerosis cutis.

Cromakalim relaxes various blood vessels, while minoxidil sulphate is more selective; they likely act on different potassium channels.

This study found a significant shift to the telogen phase in the hair growth of children with classical marasmus compared to normal children, suggesting a connection to the chronicity of the condition.

Finasteride potentially treats hair loss by reducing DHT production.

This study found that Undariopsis peterseniana extract may promote hair growth by activating specific cellular pathways, suggesting potential for treating alopecia.

This study found that both finasteride and dutasteride act as slow, time-dependent inhibitors of steroid 5α-reductase type II, with dutasteride being more efficient, influenced by the enzyme's genetic variants.

Finasteride affects prostate weights and pituitary activity differently with age.

This study reported that prenatal exposure to dihydrotestosterone altered long-term androgen metabolism in juvenile male rats, suggesting different regulatory mechanisms for 5a-reductase in hypothalamic versus pituitary tissues.

This review discusses the role of cholesterol homeostasis in hair follicle biology and its potential connections to various hair disorders, but it reports no new findings.

In this study, herbal extracts commonly used in traditional medicine were observed to significantly increase the proliferation of human dermal papilla cells, suggesting potential as alternative therapies for enhancing hair growth.

This paper reports on the structural characteristics of α-type filaments in the inner root sheath cells of guinea pig hair follicles without presenting new clinical findings.

This review discusses the cosmetic use and safety of Hypericum Perforatum Extract and Oil, finding that current data are insufficient to support their safety in formulations due to a lack of comprehensive testing.

In this study, researchers demonstrated that in a mouse model, the stimulation of mammary tumor growth due to progesterone is primarily caused by its metabolite, 5αP, not progesterone itself.

This study found that in genetically diabetic mice, supplementation with safflower or evening primrose oil prevented the decrease in certain fatty acids and improved skin conditions, but increased plasma glucose levels.

This study evaluated curcumin analogues as potential inhibitors of 17β-HSD3 in rat and human models, but it does not report new clinical findings.

This study found that petroleum ether extracts of Citrullus colocynthis reduced hair growth initiation time and advanced more hair follicles to the anagen phase in albino rats compared to untreated controls and minoxidil.

In this study, all stereoisomers of cyoctol were synthesized and tested, revealing that contrary to initial patent claims, cyoctol does not function as an anti-androgen.

This study describes the development of polyamide 6 composite fibers with amber filler, finding them suitable for use in medical textiles such as compression garments due to their biocompatibility with skin cells.

In this study, Far2-/- mice were observed to develop focal alopecia with altered sebaceous gland morphology and lower skin lipid levels compared to wildtype mice.