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Metformin has limited effectiveness for improving PCOS symptoms and lacks clear benefits, needing more research to confirm its efficacy.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

Minoxidil not effective in preventing chemotherapy-induced hair loss.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Non-ablative and ablative fractional lasers helped hair growth in some cases without major side effects, but didn't work for all hair disorders.

Dermatoscopy and videodermatoscopy are useful and reliable for tracking treatment progress in various skin conditions.

Oral contraceptives can cause skin issues like dark patches, acne, yeast infections, sensitivity to light, spider veins, skin rashes, and hair loss.

Finasteride slightly better long-term, minoxidil faster initial results, but stopping minoxidil may cause hair loss.

Testosterone replacement therapy can prevent men from fathering children and should not be used by those wanting to stay fertile.

Insulin-lowering medications show promise for PCOS symptoms but can't be the main treatment yet due to limited long-term research.

Oestrogen and thyrotropin-releasing hormone affect prolactin and its receptor in human skin and hair, suggesting new treatment options for related conditions.

The document concludes that treating PCOS requires a combination of drugs to manage reproductive and metabolic symptoms, with more research needed on combination therapies.

Metformin should be used for PCOS mainly in those with glucose intolerance, and has limited benefits for infertility or hirsutism.

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

New criteria for diagnosing frontal fibrosing alopecia include specific scalp and eyebrow hair loss as major factors and other hair loss areas and hair analysis as minor factors.

Certain genetic variations are linked to increased androgen levels in PCOS, but more research is needed to understand these connections fully.

Hormone therapies like birth control pills and spironolactone are safe and effective for treating women's adult acne.

Finasteride reduces hirsutism effectively with fewer side effects but is a second-choice treatment due to safety concerns.

Minoxidil use during pregnancy may cause fetal harm.

The VEGF +405G allele may increase the risk of PCOS in South Indian women.

Azelaic acid and anthralin are similarly effective for treating patchy hair loss.

Menopausal women have higher androgen levels, which can cause symptoms like facial hair growth and low sexual desire.

Stopping sunscreen use on the forehead led to hair regrowth in a woman with frontal fibrosing alopecia.

Finasteride worsens seizures in epilepsy rats and speeds up epileptogenesis in mice.

Using computers to analyze drugs can find new uses for them, but actual experiments are needed to confirm these uses.

Women's ovarian hormones and adrenal androgens change throughout life, affecting hair loss and health.

New acne treatments show promise as alternatives to traditional therapies.

Certain drugs can cause early hair growth in mice by affecting the nerves.

Early diagnosis and treatment of PCOS is crucial to reduce emotional distress and health risks.

Liposomes can make the antiandrogen RU 58841 more effective for skin application by reducing absorption, increasing skin retention, and targeting sebaceous structures.