12 citations,
September 2013 in “BMC Biophysics” Keratin filaments' elasticity is influenced by their terminal domains and surrounding medium.
1 citations,
December 2020 in “Journal of Chemical and Petroleum Engineering” The Gas-Antisolvent process can be effectively modeled and optimized to create Finasteride, a hair growth drug.
28 citations,
November 2020 in “Fluid Phase Equilibria” Minoxidil dissolves better in propylene glycol + water than in supercritical CO2.
February 2024 in “International Journal of Biological Macromolecules” The study created a new type of microsphere that effectively regrows hair.
13 citations,
June 2016 in “Dermatologic Therapy” Minoxidil works better when applied on a damp scalp than a dry one.
January 2014 in “대한미용학회지” Using supercritical carbon dioxide can change the size of Hinokitiol particles.
47 citations,
June 1996 in “International Journal of Legal Medicine” Hair analysis for drugs needs a better understanding of how drugs enter hair, considering factors like hair structure and pigmentation.
39 citations,
April 2010 in “International Journal of Pharmaceutics” Nanoparticles improve minoxidil skin permeation, but more research needed for effective hair growth.
33 citations,
June 1995 in “Journal of Pharmaceutical Sciences” More ethanol increases minoxidil delivery, but too much lowers efficiency.
29 citations,
January 1996 in “Journal of Pharmaceutical Sciences” Finasteride poorly inhibits type 1 5AR, affecting its effectiveness.
9 citations,
January 1989 in “Sen'i Gakkaishi” Wool and hair fibers absorb moisture similarly due to their keratin structure, with the amount of non-crystalline areas affecting the moisture uptake.
7 citations,
February 2019 in “Journal of Molecular Liquids” Minoxidil dissolves better in propylene glycol and water as temperature and propylene glycol amount increase.
3 citations,
August 1980 in “Acs Symposium Series” Hair increases in size when it absorbs water, and treatments like bleaching affect how much water it can take in.
1 citations,
July 2021 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin” Rubbing skin increases absorption of water-soluble drugs from lotions and creams, but not oil-soluble drugs.
The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.
55 citations,
June 2009 in “Journal of Pharmaceutical Sciences” Minoxidil promotes hair growth by penetrating skin, with ethanol-containing formulas working best.
54 citations,
October 2002 in “Journal of controlled release” Medium lipophilic substances penetrate skin best, and adding ethanol can increase delivery to hair follicles.
52 citations,
February 1985 in “Archives of Dermatology” Minoxidil absorbs poorly through skin, with low risk of side effects at 1-2% concentration.
45 citations,
November 2017 in “Biomaterials” Researchers found a new way to create hair-growing structures in the lab that can grow hair when put into mice.
40 citations,
January 2018 in “Pharmaceutics” Eucalyptol and oleic acid in nanoemulsions improve minoxidil delivery to hair follicles, potentially enhancing hair loss treatment.
36 citations,
October 2009 in “Journal of Investigative Dermatology” Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.
35 citations,
February 2006 in “Textile Research Journal” Enzymes xylanase and pectinase clean wool and specialty hair fibers effectively without damage, offering an eco-friendly alternative to soap and hot water.
33 citations,
June 2007 in “International Journal of Pharmaceutics” The conclusion is that measuring how drugs partition into artificial sebum is important for predicting their delivery into hair and sebaceous follicles, and it provides better information than traditional methods.
25 citations,
January 2013 in “Journal of Industrial and Engineering Chemistry” Some herbal extracts, especially when used in cubosomal suspensions, were as effective as Minoxidil in promoting hair growth.
25 citations,
June 1990 in “Journal of Pharmaceutical Sciences” Longer contact time increases minoxidil absorption, but doesn't affect metabolism.
24 citations,
June 2020 in “Industrial Crops and Products” Activated carbon fibers from Metaplexis japonica seed hair are highly effective for removing the dye methylene blue from water.
20 citations,
October 2018 in “Physics and chemistry of liquids” Minoxidil dissolves better in ethanol-water mixtures at different temperatures, with water playing a key role.
19 citations,
March 1997 in “Journal of Cutaneous Pathology” Alopecia areata involves specific T-cells, unlike androgenetic alopecia.
18 citations,
August 2014 in “Lipids” Human hair has more unsaturated fats inside than on the surface, and certain lipids may help bind the outer and inner layers together.
16 citations,
March 2008 in “International journal of pharmaceutics” Different factors like pH, gel type, and chemical enhancers affect how well hydrocortisone gets into hair follicles, and less hydrated skin doesn't work well with the test method.