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      Severe Cutaneous Adverse Reactions to Drugs

      research Severe cutaneous adverse reactions to drugs

      273 citations , May 2017 in “The Lancet”
      This review discusses the diagnosis and management of severe cutaneous adverse reactions to drugs and provides guidance for physicians to improve patient outcomes, but it reports no new clinical results.
      Teriflunomide and Its Mechanism of Action in Multiple Sclerosis

      research Teriflunomide and Its Mechanism of Action in Multiple Sclerosis

      253 citations , April 2014 in “Drugs”
      This review discusses the preclinical and clinical data on teriflunomide for multiple sclerosis, highlighting its selective action on immune cells without causing clinical immune suppression, and provides no new clinical results.
      Alopecia Areata: A Review of Disease Pathogenesis

      research Alopecia areata: a review of disease pathogenesis

      191 citations , May 2018 in “British journal of dermatology/British journal of dermatology, Supplement”
      This study reviewed recent theories on alopecia areata's pathogenesis, highlighting its autoimmune nature due to immune privilege disruption in hair follicles, and noted current treatments have limited efficacy with high relapse rates, underscoring the need for further research into its mechanisms for better therapies.
      Alopecia Areata: A Multifactorial Autoimmune Condition

      research Alopecia areata: A multifactorial autoimmune condition

      148 citations , December 2018 in “Journal of autoimmunity”
      This review discusses genetic and environmental factors contributing to autoimmunity in alopecia areata and reports no new clinical findings, emphasizing the need for further study on its aetiology and pathophysiology.
      Transplantation Immunology: Solid Organ and Bone Marrow

      research Transplantation immunology: Solid organ and bone marrow

      139 citations , February 2010 in “ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology”
      This review outlines the advancements in organ and tissue transplantation since the discovery of the human MHC and reports no new clinical results.
      Acne, the Skin Microbiome, and Antibiotic Treatment

      research Acne, the Skin Microbiome, and Antibiotic Treatment

      134 citations , January 2019 in “American journal of clinical dermatology”
      This review summarizes recent research on the skin microbiome's role in acne development and how antibiotic treatments affect skin microbes, but it reports no new clinical results.
      Tregs: Where We Are and What Comes Next?

      research Tregs: Where We Are and What Comes Next?

      130 citations , November 2017 in “Frontiers in Immunology”
      This review explores recent findings on regulatory T cells, focusing on their unique functions in non-lymphoid tissues and new mechanisms of action, but presents no original clinical results.
      The Circadian Clock in Skin

      research The Circadian Clock in Skin

      127 citations , January 2015 in “Journal of Biological Rhythms”
      This review discusses the role of the circadian clock in skin functions such as cell proliferation and UV protection and reports no new results; the authors note its potential in studying immune regulation and seasonal behaviors.
      Probiotic Bacteria Induce a Glow of Health

      research Probiotic Bacteria Induce a ‘Glow of Health’

      127 citations , January 2013 in “PLOS ONE”
      This study found that feeding aged mice a probiotic yogurt induced changes leading to thicker, healthier fur, suggesting a bacteria-triggered interleukin-10-dependent mechanism that mimics signs of youth and reproductive fitness.
      Regulatory T Cells: The Many Faces of Foxp3

      research Regulatory T Cells: the Many Faces of Foxp3

      125 citations , September 2019 in “Journal of Clinical Immunology”
      This review summarizes recent advances in Treg cell biology, focusing on Foxp3's role in immune regulation and therapeutic reprogramming for immune dysregulatory disorders, but reports no new clinical results.
      Targeting the Janus Kinase Family in Autoimmune Skin Diseases

      research Targeting the Janus Kinase Family in Autoimmune Skin Diseases

      124 citations , October 2019 in “Frontiers in Immunology”
      This review discusses the role of the JAK-STAT pathway in autoimmune skin diseases and suggests potential therapeutic benefits of JAK inhibitors, but reports no new experimental results.
      From Causes of Aging to Death from COVID-19

      research From causes of aging to death from COVID-19

      122 citations , June 2020 in “Aging”
      This review discusses the hyperfunction theory of aging as a key factor in COVID-19 vulnerability, highlighting the potential of anti-aging interventions like rapamycin to reduce this risk.
      Extraskeletal Actions of Vitamin D

      research Extraskeletal actions of vitamin D

      119 citations , July 2016 in “Annals of the New York Academy of Sciences”
      This review examines the impact of vitamin D signaling in extraskeletal tissues and notes that expected benefits from animal and cell studies have not been consistently replicated in human clinical trials.
      Janus Kinase Inhibitors in Dermatology: A Systematic Review

      research Janus kinase inhibitors in dermatology: A systematic review

      116 citations , February 2017 in “Journal of the American Academy of Dermatology”
      This systematic review found that Janus kinase inhibitors have shown beneficial effects for psoriasis and alopecia areata, with promising preliminary results in other skin conditions, though more research is needed to define dosing and safety profiles.
      Regulatory T Cells in Skin: Role of Foxp3+ CD4+ Tregs in Skin Homeostasis and Immune Tolerance

      research Regulatory T cells in skin

      110 citations , July 2017 in “Immunology”
      This review discusses the role of regulatory T cells in skin, including their impact on hair follicle regeneration, wound healing, and immune tolerance, without presenting new clinical findings.
      Human αβ and γδ T Cells in Skin Immunity and Disease

      research Human αβ and γδ T Cells in Skin Immunity and Disease

      83 citations , June 2018 in “Frontiers in immunology”
      This review discusses the roles of αβ and γδ T cells in skin health and disease and reports no new clinical results; the authors highlight potential therapeutic developments.