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Increased HIF-1α is linked to the inflammation and severity of hidradenitis suppurativa, suggesting treatments that lower HIF-1α could help.

Vitamin B5 and coenzyme A may help regulate the immune system and could improve treatments for chronic diseases and cancer.

Certain immune cells contribute to severe hair loss in chronic alopecia areata, with Th17 cells possibly having a bigger impact than cytotoxic T cells.

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

Foxp3+ Regulatory T Cells are important for immunity and tolerance, affect hair growth and wound healing, and their dysfunction can contribute to obesity-related diseases and other health issues.

ECM-inspired wound dressings can help heal chronic wounds by controlling macrophage activity.

New targeted immunotherapies are improving treatment for inflammatory skin diseases.

Phospholipase A2 enzymes play key roles in skin health and disease.

Certain fungi protect skin health, but changes can allow harmful fungi to cause serious infections, needing more research for treatment and control.

People with polycystic ovary syndrome have a higher chance of having chronic thyroiditis.

Certain microRNAs are linked to various skin diseases and could be used to diagnose and treat these conditions.

Immune checkpoint inhibitors can cause skin issues but are linked to better cancer outcomes.

An imbalance between certain immune cells is linked to a chronic skin condition and may be influenced by obesity, smoking, and autoimmune issues.

Faulty Notch signalling may cause hair follicle changes and inflammation in hidradenitis suppurativa.

The review shows that skin symptoms like chronic fungal infections, hair loss, and skin depigmentation are key for early detection and management of APECED.

Epiduo® is an effective first-line acne treatment that reduces inflammation and combats antibiotic resistance.

The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.

Anti-IL-12/IL-23 antibody therapy effectively treats psoriasiform skin lesions in IBD patients.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

Certain types of T cells are essential for healthy skin and play a role in skin diseases, but more research is needed to improve treatments.

Pantethine may boost the immune system's ability to fight sarcoma.

Rhodococcus equi causes severe pneumonia in young foals, and effective vaccines are needed due to foals' weak immune responses.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.

Alopecia areata severity and treatment response are linked to specific cytokine levels.

Certain immune-related proteins are higher in people with alopecia and their healthy relatives, hinting at a genetic link.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

Both vitiligo and alopecia areata involve an immune response triggered by stress and specific genes, with treatments targeting this pathway showing potential.