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      Prospect of Stem Cell Conditioned Medium in Regenerative Medicine

      research Prospect of Stem Cell Conditioned Medium in Regenerative Medicine

      298 citations , January 2014 in “BioMed Research International”
      This review discusses various methods for obtaining stem cell-derived conditioned media and its applications in disease treatment, finding generally positive results but highlighting the need for standardized production methods.
      The Rotterdam Study: 2014 Objectives and Design Update

      research The Rotterdam Study: 2014 objectives and design update

      266 citations , November 2013 in “European Journal of Epidemiology”
      This article outlines the rationale and design of the Rotterdam Study, summarizes its major findings, and updates its objectives and methods; it reports no new research results.
      Recent Advances in Electrospun Nanofibers for Wound Healing

      research Recent advances in electrospun nanofibers for wound healing

      262 citations , May 2017 in “Nanomedicine”
      This review examines recent advancements in electrospun nanofibers for wound healing applications, but reports no new experimental results, highlighting their potential in sutures, dressings, and skin regeneration.
      Genetic, Hormonal, and Metabolic Aspects of PCOS: An Update

      research Genetic, hormonal and metabolic aspects of PCOS: an update

      258 citations , July 2016 in “Reproductive Biology and Endocrinology”
      This abstract reviews the characteristics and health risks associated with polycystic ovary syndrome and does not report new findings, highlighting the syndrome's multifactorial nature.
      A Family Business: Stem Cell Progeny Join the Niche to Regulate Homeostasis

      research A family business: stem cell progeny join the niche to regulate homeostasis

      254 citations , January 2012 in “Nature Reviews Molecular Cell Biology”
      This review discusses the role of stem cell progeny as integral components of stem cell niches, offering feedback that may influence different stem cell systems' microenvironments, but it presents no new research findings.
      Teriflunomide and Its Mechanism of Action in Multiple Sclerosis

      research Teriflunomide and Its Mechanism of Action in Multiple Sclerosis

      253 citations , April 2014 in “Drugs”
      This review discusses the preclinical and clinical data on teriflunomide for multiple sclerosis, highlighting its selective action on immune cells without causing clinical immune suppression, and provides no new clinical results.
      Tracing the Cellular Origin of Cancer

      research Tracing the cellular origin of cancer

      232 citations , January 2013 in “Nature Cell Biology”
      Understanding where cancer cells come from helps create better prevention and treatment methods.
      Molecular Mechanisms of Androgenetic Alopecia

      research Molecular mechanisms of androgenetic alopecia

      229 citations , August 2002 in “Experimental Gerontology”
      This paper discusses key mechanisms of androgen metabolism in androgenetic alopecia and reports the effectiveness of treatments like oral finasteride and topical minoxidil, highlighting the limited success rate due to factors like follicular inflammation.
      Biology of the Hair Follicle: The Basics

      research Biology of the Hair Follicle: The Basics

      224 citations , March 2006 in “Seminars in Cutaneous Medicine and Surgery”
      This article discusses the hair follicle's regenerative cycles and the molecular mechanisms influencing them, emphasizing the need for therapeutic targeting of the "hair cycle clock" to manage hair growth disorders, without reporting new research findings.
      Signaling Involved in Hair Follicle Morphogenesis and Development

      research Signaling Involved in Hair Follicle Morphogenesis and Development

      223 citations , January 2014 in “International Journal of Molecular Sciences”
      This article reviews the complex signaling pathways between epithelial and mesenchymal cells crucial for hair follicle morphogenesis, highlighting the Wnt pathway's role as a master regulator without reporting new experimental findings.
      More Than One Way to Skin

      research More than one way to skin . . .

      218 citations , April 2008 in “Genes & Development”
      This research discusses how epithelial stem cells in the skin maintain normal homeostasis, contribute to wound repair, and highlights the importance of these processes, as defects can lead to skin diseases including cancers, but provides no new experimental results.
      Androgens and Hair Growth

      research Androgens and hair growth

      209 citations , September 2008 in “Dermatologic Therapy”
      This review discusses the role of androgens in hair follicle regulation and suggests that a better understanding could enhance treatments for conditions like hirsutism and alopecia, but does not present new findings.
      Hair Follicle Stem Cells: Walking the Maze

      research Hair follicle stem cells: Walking the maze

      165 citations , June 2007 in “European Journal of Cell Biology”
      This review discusses the various stem cell populations associated with hair follicles and their potential in regenerative medicine, highlighting differences between murine and human hair follicles but reports no new clinical results.
      The Hair Follicle as an Estrogen Target and Source

      research The Hair Follicle as an Estrogen Target and Source

      159 citations , July 2006 in “Endocrine Reviews”
      This article discusses the influence of estrogens on hair follicle growth and metabolism, suggesting a significant role alongside androgens in hair growth control but reports no new clinical results.
      Probing the Effects of Stress Mediators on the Human Hair Follicle

      research Probing the Effects of Stress Mediators on the Human Hair Follicle

      159 citations , November 2007 in “American Journal of Pathology”
      In this study, researchers found that substance P triggered premature catagen development and immune changes in human scalp hair follicles, providing a possible biological link between stress and hair loss conditions like telogen effluvium and alopecia areata.
      Hierarchical Patterning Modes Orchestrate Hair Follicle Morphogenesis

      research Hierarchical patterning modes orchestrate hair follicle morphogenesis

      149 citations , July 2017 in “PLoS Biology”
      This study found that hair follicle patterning in development may arise from a combination of epidermal prepattern signals and mesenchymal self-organisation, with fibroblast growth factor and bone morphogenetic protein activities playing key roles.
      The Immune Functions of Keratinocytes in Skin Wound Healing

      research The Immune Functions of Keratinocytes in Skin Wound Healing

      147 citations , November 2020 in “International Journal of Molecular Sciences”
      This review discusses the immune roles of keratinocytes in wound healing and chronic wound inflammation, emphasizing their potential impact on chronic wound pathology and highlighting areas for future research.