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Glossary Tetrahydrocannabinol

primary psychoactive compound in cannabis, often called THC

Tetrahydrocannabinol, commonly known as THC or Δ9-THC, is the primary psychoactive compound found in cannabis. It interacts with the endocannabinoid system in the brain, particularly the CB1 receptors, to produce effects such as euphoria, altered perception, and relaxation.

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research Prenatal Exposure to Delta-9-tetrahydrocannabinol (THC) Alters the Expression of miR-122-5p and Its Target Igf1r in the Adult Rat Ovary

9 citations , July 2022 in “International Journal of Molecular Sciences”

This study suggests that prenatal exposure to THC may negatively impact ovarian health in rats by altering miRNA expression, potentially leading to reproductive issues such as subfertility or premature reproductive senescence.

research Segmental Hair Analysis for 11-Nor- 9-Tetrahydrocannabinol-9-Carboxylic Acid and the Patterns of Cannabis Use

30 citations , March 2012 in “Journal of Analytical Toxicology”

This study found that concentrations of THCCOOH in hair do not correlate well with self-reported cannabis use due to inaccuracies in the self-reported data, but it provides preliminary insights into usage patterns.

research Cannabinoid Compounds as a Pharmacotherapeutic Option for the Treatment of Non-Cancer Skin Diseases

3 citations , December 2022 in “Cells”

This review examines the role of cannabinoid compounds in treating various skin conditions and suggests their potential as systemic and topical therapies, but it reports no new experimental results.

research Cannabinoids and Their Receptors in Skin Diseases

1 citations , November 2023 in “International journal of molecular sciences”

This article highlights that while cannabinoids show potential for treating various skin conditions, current evidence is largely preclinical, with a need for comprehensive clinical trials to confirm these promising effects.

The Impact of Cannabis Use on Local Anesthetic Dosing During Hair Restoration Surgery: A Case Report, Proposed Mechanisms, and Clinical Recommendations

research The impact of cannabis use on local anesthetic dosing during hair restoration surgery: a case report, proposed mechanisms, and clinical recommendations

March 2025 in “Journal of Dermatological Treatment”

In this case report, a patient required more local anesthetic than usual for hair transplant surgery, which the authors suggest may be due to cannabis use impacting pain sensitivity and anesthetic clearance.

research Improved forensic hair evidence for drugs of abuse by mass spectrometry

January 2016

This paper discusses advancements in forensic hair analysis, emphasizing a novel DART–HRMS method that improves the accuracy and efficiency of detecting drug use timelines.

research Mechanism of cannabinoid incorporation in hair

April 2012 in “J. Willard Marriott Library”

This study concluded that THC and THCA incorporate into hair by a mechanism independent of hair pigmentation, likely influenced by indirect deposition via sebum and skin.

research Novel potential avenues for the therapy of Tourette syndrome: Cannabinoid- and steroid-based interventions

January 2022 in “International review of movement disorders”

In this review, the authors found that cannabinoids and steroid-related drugs show potential for treating Tourette syndrome, but existing evidence is limited and further research is needed to confirm their efficacy and safety.

research Potential Medical Uses of Cannabigerol: A Brief Overview

14 citations , January 2017 in “Elsevier eBooks”

This review explores cannabigerol (CBG) as a potential therapeutic agent with various pharmacological activities but reports no new clinical results, emphasizing the need for further research on its efficacy and safety.

research Scientific Evidence for the Cosmetic Skin and Hair Benefits of Hemp-derived Cannabinoids: A Review

January 2024 in “Clinical dermatology open access journal”

This paper reviews existing research on the cosmetic benefits of hemp-derived cannabinoids for skin and hair, highlighting their unique mechanisms of action, while discussing formulation, legal, and regulatory challenges associated with using these compounds in cosmetic products.

research A Summary of Pre-Clinical and Clinical Evidence for Cannabinoid Hair Follicle Effects

January 2022 in “Clinical dermatology open access journal”

This review summarizes research on cannabinoids like CBD and THCV, reporting that they improve hair growth in patients with androgenetic alopecia when applied topically, with CBD showing a dose-dependent effect.

research Reversal of Baldness in Patient Receiving Minoxidil for Hypertension

95 citations , December 1980 in “The New England Journal of Medicine”

Minoxidil helped bald patient regrow hair.

research HAIR ANALYSIS FOR DRUGS OF ABUSE. PLAUSIBILITY OF INTERPRETATION

60 citations , December 2005 in “Biomedical Papers”

This article reviews hair analysis for drug detection and its applications in various fields, but reports no new research findings, emphasizing the need to consider the method's complexities and potential pitfalls.

research Neuroactive Steroids and Ethanol Exposure: Relevance to Ethanol Sensitivity and Alcohol Use Disorders Risk

1 citations , January 2019 in “Elsevier eBooks”

This review suggests that GABAergic neuroactive steroids modulated by alcohol could play a role in vulnerability to alcohol use disorders, providing a rationale for further therapeutic exploration.

research An Unusual Case of Elevated Testosterone: When Testosterone by Dialysis Saves the Day

September 2025 in “Cureus”

In this case report, a male patient with hair loss showed unusually high testosterone levels without other symptoms or supplement use; follow-up testing revealed normal levels, showcasing the importance of considering testosterone-protein binding differences and using equilibrium dialysis for accurate assessment.

research Disappearance of Tramadol and THC-COOH in Hair After Discontinuation of Abuse. Two Different Profiles

7 citations , January 2019 in “Journal of Analytical Toxicology”

This study found that hair samples from chronic tramadol and cannabis users showed positive drug presence for 3-4 months and 6-7 months, respectively, after discontinuation.

research Development of MALDI-TOF-MS and MALDI-MSI methods for hair analysis and evaluation of cosmetic treatments

February 2024 in “Digital Library of Theses and Dissertations (Universidade de São Paulo)”

This study demonstrated that using a mass spectrometry imaging technique, researchers were able to visualize the incorporation of argan, avocado, and coconut oils into hair fibers, suggesting their potential in cosmetic and alopecia treatments by confirming oil absorption and fiber modification.

research TRP Channels in Skin Biology and Pathophysiology

124 citations , December 2016 in “Pharmaceuticals”

This review discusses the functions and potential therapeutic targeting of TRP ion channels in the skin, noting their involvement in both physiological processes and various pathological conditions, but reports no new experimental results.

Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research

research Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research

123 citations , December 2015 in “Journal of Neuroendocrinology”

This review discusses recent strategies targeting the neuroactive steroid biosynthetic pathway to enhance neurosteroidogenesis, highlighting their potential benefits for neurodegenerative and neuropsychiatric diseases, but reports no new clinical findings.

research The endocannabinoid system of the skin. A potential approach for the treatment of skin disorders

75 citations , August 2018 in “Biochemical pharmacology”

This review discusses the potential of targeting the endocannabinoid system for treating skin disorders and reports no new clinical results, highlighting the need for further research.

research Treatments for Androgenetic Alopecia and Alopecia Areata

72 citations , January 2001 in “Drugs”

This review discusses current and emerging drug therapies for treating androgenetic alopecia and alopecia areata, and reports no clinical results; it highlights a need for improved and novel treatments.

research Beta-caryophyllene enhances wound healing through multiple routes

67 citations , December 2019 in “PloS one”

This study found that beta-caryophyllene enhanced re-epithelialization in cutaneous wounds of female mice, suggesting its potential for improving wound healing through multiple pathways.

research What should it take to describe a substance or product as 'sperm-safe'

58 citations , March 2013 in “Human Reproduction Update”

This review discusses various substances that can impact male fertility and stresses that products should be confirmed 'sperm-safe' through rigorous testing, not assumptions; it reports no new study results.

research Cannabinoids: Current and Future Options to Treat Chronic and Chemotherapy-Induced Neuropathic Pain

50 citations , May 2019 in “Drugs”

This review discusses the potential therapeutic effects of targeting the endocannabinoid system for chemotherapy-induced peripheral neuropathy and reports no new clinical results, highlighting the need for ongoing research.

research High resolution full scan liquid chromatography mass spectrometry comprehensive screening in sports antidoping urine analysis

49 citations , December 2017 in “Journal of pharmaceutical and biomedical analysis”

This study developed and validated a high-resolution mass spectrometry method to screen for prohibited substances and analyze six endogenous steroids in urine according to World Antidoping Agency requirements, demonstrating its effectiveness for antidoping analysis.

research Analysis of sequential hair segments reflects changes in the metabolome across the trimesters of pregnancy

48 citations , January 2018 in “Scientific Reports”

This pilot study found that hair metabolome analysis may help differentiate pregnancy complications from healthy pregnancies by revealing significant metabolite differences between trimesters.

Xenobiotic-Metabolizing Enzymes in the Skin of Rat, Mouse, Pig, Guinea Pig, Man, and in Human Skin Models

research Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models

38 citations , June 2018 in “Archives of Toxicology”

This review suggests that skin may largely protect itself from CYP-generated reactive metabolites due to higher conjugating enzyme activities, while highlighting limitations in modeling human skin metabolism experimentally.

research Experimental and thermodynamic analyses of supercritical CO2-Solubility of minoxidil as an antihypertensive drug

28 citations , November 2020 in “Fluid Phase Equilibria”

In this study, researchers measured the solubility of Minoxidil in supercritical CO₂ under various temperature and pressure conditions and created models to estimate solubility based on different predictive approaches.

research Micro-segmental hair analysis: detailed procedures and applications in forensic toxicology

27 citations , March 2022 in “Forensic Toxicology”

This review discusses micro-segmental hair analysis for forensic toxicology, emphasizing its potential to provide detailed drug distribution profiles and its application in investigations, while noting the method's limitations and future perspectives.

research Gilles de la Tourette syndrome – A treatable condition?

24 citations , July 2016 in “Revue Neurologique”

This review discusses treatment options for tics in Gilles de la Tourette syndrome, highlighting existing therapies and potential future advancements, but reports no new clinical findings.