17 citations
,
August 2019 in “Archives of Cardiovascular Diseases” In this study, the authors observed that testosterone therapy shortened the QTc interval and normalized T-wave morphology in men with acquired LQTS or TdP linked to hypogonadism, suggesting testosterone may be helpful in treatment.
15 citations
,
May 2021 in “British journal of dermatology/British journal of dermatology, Supplement” In this review, the authors discuss the potential for cell therapy, such as hematopoietic stem cell transplantation and mesenchymal stromal cells, to treat severe psoriasis unresponsive to biological therapies, while highlighting the associated risks, costs, and regulatory challenges.
10 citations
,
September 2018 in “Regenerative Medicine” This review explores the mechanism and potential applications of wound-induced hair follicle neogenesis but reports no new clinical results, highlighting the need for further research in hair regeneration therapies.
6 citations
,
November 2018 in “American journal of transplantation” This study reported that using UVB preirradiation and anti-CD154 antibody treatment in a humanized mouse model prolonged hair follicle allograft survival and reduced immune cell infiltration without needing generalized immunosuppression.
1 citations
,
March 2012 in “Journal of Dermatological Science” This study found that various steroids affected the mRNA expression of enzymes involved in lipid metabolism in hamster flank organs, with different impacts depending on the steroid and combination used.
January 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, the researchers found that deleting ceramide synthase 4 in the skin's epidermis alters stem cell differentiation, disrupting hair follicle structure and barrier function, potentially leading to immune responses similar to atopic dermatitis.
January 2009 in “Journal watch” This study enrolled nine patients to investigate the effects of oral psoralen and ultraviolet A therapy plus oral prednisolone for treating alopecia areata.
Alopecia areata, a type of hair loss, may be passed through T cells and has genetic links, while treatments vary in effectiveness. Male pattern baldness can be treated with finasteride and is influenced by androgens in hair follicles.
193 citations
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May 2008 in “Development” This study found that activating β-catenin signaling in embryonic epidermis promoted hair follicle characteristics at the expense of normal epidermal differentiation, leading to early pigmentation and innervation.
191 citations
,
November 1959 in “Annals of the New York Academy of Sciences” This article reports electron microscope studies on the structure of hair and wool, but it does not present new clinical findings.
56 citations
,
November 1958 in “The Journal of Cell Biology” This study used electron microscopy to identify a distinct dendritic cell in the human epidermis, similar to the melanocyte, with unique structural features and variable melanin content.
51 citations
,
September 2012 in “Biomacromolecules” This study found that disulfide bonds in keratin increase its strength and toughness, with some loss of α-helical structure under load, highlighting their role in trichocyte α-keratin's mechanical properties.
39 citations
,
January 2018 in “British journal of dermatology/British journal of dermatology, Supplement” This review highlights that although acne and hidradenitis suppurativa share a focus on hair follicles and innate inflammation, their genetics, risk factors, and bacterial involvement differ significantly.
23 citations
,
November 2015 in “Phytotherapy Research” This study found that cucurbitacin I from bitter melon most effectively inhibited the growth of lung cancer cells and promoted hair cell growth in cell cultures.
18 citations
,
June 1998 in “Circulation” This letter discusses how outdated measurement technology may obscure evidence of essential fatty acid deficiency in low-fat diet patients, potentially leading to undiagnosed EFA insufficiencies related to heart disease.
15 citations
,
January 1992 in “Sen'i Gakkaishi” This study suggests that the cell membrane complex in hair cuticles contains hydrophilic regions with disulfide bonds allowing polymer uptake and hydrophobic lamella-like lipid layers.
11 citations
,
January 2011 in “Journal of Pharmacy and Pharmacology” This study found that inducing hair follicles into the anagen stage by plucking significantly enhances antibody responses in mice after topical DNA vaccine application, compared to retinoic acid or TPA treatments.
10 citations
,
January 2019 in “International Immunology” This review discusses the interactions between immune cells and the skin epithelium and their impact on maintaining barrier function, emphasizing the potential to enhance epithelial barrier function in inflammatory diseases.
8 citations
,
April 2017 in “Journal of The Royal Society Interface” This study found that keratin intermediate filaments in the hair of GAN patients are altered, showing decreased diffraction signals and increased stiffness, strength, and extensibility.
8 citations
,
December 2006 in “Journal of Vascular Surgery” Foam sclerotherapy for varicose veins may cause unexpected hair growth.
4 citations
,
May 2022 in “Journal of Drug Delivery Science and Technology” This research observed that nanoliposomes delivering a combination of bioactive peptides significantly promoted hair growth in vitro and in vivo by enhancing the proliferation and function of hair growth-targeted cells in C57BL/6 mice, suggesting a promising approach for treating androgenetic alopecia.
4 citations
,
October 2017 in “Indian drugs” This study isolated and characterized several chemical compounds from the leaves and flowers of Hibiscus rosa-sinensis, using spectral data and chemical reactions for structure elucidation.
1 citations
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October 2021 in “Journal of the European Academy of Dermatology and Venereology” This study reported that the tested hair lotion significantly reduced hair loss and accelerated recovery in women with acute telogen effluvium compared to a mild shampoo alone.
July 2024 in “Medical alphabet” In this review, researchers discuss the factors contributing to early graying, such as genetic predisposition, oxidative stress imbalance, and nutrient deficiencies, and highlight potential restoration methods involving palmitoyl tetrapeptide-20 and the endocannabinoid system in hair follicles.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This research suggests that hair keratins evolved from claw keratins in a hairless ancestor, with Hoxc13 controlling their expression in tetrapods, evidenced by the knockout of Hoxc13 hindering claw formation in Xenopus tropicalis frogs.
November 2022 in “Skin Appendage Disorders” This study found that a 6-month treatment with 2% palmitoyl tetrapeptide 20 showed no significant improvement in reducing hair graying in patients, despite theoretical potential.
August 2019 in “Journal of The American Academy of Dermatology” RV3466F lotion significantly reduces hair loss and improves acute telogen effluvium.
This study found that keratin intermediate filaments in the hair of patients with giant axonal neuropathy were structurally altered, resulting in hair that was stiffer, stronger, and more extensible.
May 2015 in “Journal of The American Academy of Dermatology” This study found that oral minoxidil 5 mg daily significantly improves hair growth in men with male pattern hair loss, demonstrating safety with minor side effects such as hypertrichosis and pedal edema.
January 2015 in “Hair therapy & transplantation” This review discusses natural and botanical products examined for treating alopecia and reports no clinical results; the authors note growing research interest in these treatments.