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Isotretinoin effectively treats severe acne and similar conditions, but has common, mostly reversible side effects, requiring careful patient monitoring.

Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.

Substances from Chinese medicines show promise for immune support and disease prevention, but the way they are processed affects their effectiveness.

Fat cells in the skin help start healing and form important repair cells after injury.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

Most people on isotretinoin had chapped lips, but only a few stopped the medicine due to side effects.

Hibiscus plant extracts may have health benefits like lowering blood pressure and protecting the heart.

Cytokeratin 19 and cytokeratin 15 are key markers for monitoring the quality and self-renewing potential of engineered skin.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

Rhodococcus equi causes severe pneumonia in young foals, and effective vaccines are needed due to foals' weak immune responses.

Potassium channel openers could help treat cardiovascular diseases and asthma but require better targeting to specific tissues for effective use.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

No effective treatment for frontal fibrosing alopecia was found, but oral 5-alpha-reductase inhibitors had the best response; for lichen planopilaris, topical corticosteroids were commonly used but had a high relapse rate.

Stress increases nerve fibers and immune cell activity in mouse skin, possibly worsening skin conditions.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

Some drugs can cause skin, nail, and hair problems, which are important for healthcare professionals to recognize and report.

Postinflammatory hyperpigmentation causes dark skin patches and needs personalized treatment.

Animals that change color with the seasons mainly do so in response to daylight changes, but climate change is causing camouflage problems that may require evolutionary changes.

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Finasteride may cause long-lasting sexual side effects.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

Fetal wound healing changes with development, affecting inflammation and collagen, which may influence scarring.