17 citations
,
December 2015 in “Bioorganic & Medicinal Chemistry” 3-tetrazolo steroidal analogs can strongly inhibit the enzyme linked to hair loss.
15 citations
,
May 2022 in “Fermentation” This study found that fermented camel milk containing 50% pumpkin seed milk significantly improved oxidative stress markers in rats and enhanced sensory and physicochemical properties compared to untreated groups.
15 citations
,
June 2016 in “Computers in Biology and Medicine” This study's simulation found that Ascorbyl Tetraisopalmitate penetrates more efficiently through the skin's stratum corneum than via the infundibulum, following different pathways and dynamics in each membrane.
13 citations
,
June 2006 in “Pituitary” This article reports on a case where a 26-year-old woman with acromegaloidism was found to have X-tetrasomy, suggesting it should be considered in differential diagnoses due to its potential impact on growth-related genes.
12 citations
,
September 2018 in “International Journal of Cosmetic Science” This study demonstrated that the biomimetic peptide PTP20 may help preserve hair pigmentation and reduce greying by enhancing melanocyte function and increasing melanin production in human hair follicles.
3 citations
,
May 1964 in “Nature”
2 citations
,
October 2020 in “The Journal of clinical and aesthetic dermatology” In this randomized controlled study, the researchers found that an herbal extract combination showed similar efficacy to 3% minoxidil solution in treating androgenetic alopecia over 24 weeks, with no significant safety concerns, suggesting it might be a viable alternative treatment.
2 citations
,
February 2012 in “PubMed” This study found that Gp₄G increased hair length, papilla cell numbers, and versican deposition in treated animals, potentially through alterations in hair follicle phases and nucleotide concentrations.
1 citations
,
January 2017 in “SAGE Open Medical Case Reports” This case report suggests that exacerbations of alopecia areata in a 40-year-old woman may be associated with sodium tetradecyl sulphate foam sclerotherapy treatments for varicose veins.
March 2025 in “Journal of Science Natural Science” This study successfully synthesized acetyl tetrapeptide-3 on a laboratory scale with over 56% yield and 100% purity, supporting its use in developing hair loss and scalp care products.
September 2018 in “Journal of Society of Cosmetic Chemists of Japan” This study found that applying a solution containing oil-soluble vitamin C to damaged hair improved hair cuticle condition and water repellency, suggesting a new cosmetic function beyond its known skin whitening effects.
March 2012 in “Korean Journal of Microscopy” This study found that nanoparticles can penetrate the skin, but artifacts produced during specimen preparation complicate accurate observation, and proposed a method for reducing errors in imaging quantum dots as tracers.
188 citations
,
March 2018 in “Frontiers in Immunology” This review discusses the role of regulatory T-cells in tissue repair and regeneration across various organs and reports no new clinical results.
September 2013 in “Regenerative Medicine” This summary reports that γδ T cells play a role in regulating hair follicle formation during wound healing in adult skin.
164 citations
,
December 1984 in “Proceedings of the National Academy of Sciences” This study found that TCDD significantly reduced EGF receptor binding in various animal models, linked to toxic symptoms like weight loss and developmental delays, with receptor phosphorylation persisting several days.
86 citations
,
August 2011 in “Toxicological sciences” In this study, researchers found that TCDD exposure accelerated differentiation and altered gene expression in human epidermal cells, indicating the epidermal barrier as a target of TCDD-activated AHR.
79 citations
,
October 2003 in “PubMed” In this study, PKCepsilon transgenic mice showed increased TNFalpha shedding during skin tumor promotion, which may contribute to the development of metastatic squamous cell carcinoma.
77 citations
,
January 1980 in “Carcinogenesis” This study found that TPA was significantly more effective than mezerein in inducing dark basal keratinocytes in mouse skin, which may be important in early tumor promotion stages.
60 citations
,
December 1988 in “Journal of Biochemical Toxicology” In this study, TCDD administered to male rats down-regulated EGF receptor in liver plasma membranes and increased protein kinase activity, suggesting EGF receptor–mediated toxicological effects.
45 citations
,
March 1997 in “Journal of Investigative Dermatology” TCDD changes skin gene expression and may harm skin health.
43 citations
,
January 2016 in “Oxidative medicine and cellular longevity” This review discusses the biological effects and mechanisms of THSG in antiaging and related disease treatments but reports no new experimental findings.
37 citations
,
January 1986 in “Carcinogenesis” This study found that TPA treatment transiently induces high levels of ODC in mouse epidermal cells, particularly around hair follicles, with localization reduced by retinoic acid or cycloheximide pretreatment.
26 citations
,
January 1992 in “Carcinogenesis” This study suggests that chronic treatment with TPA in mouse skin selectively expands a keratinocyte subpopulation hyperinducible for ODC, which may be a key target for neoplastic transformation.
13 citations
,
October 2017 in “Bioorganic & Medicinal Chemistry” This study found that compound 3, a tetrahydropyridoindole carboxymethylated at position 5, significantly inhibited sorbitol accumulation in both rat eye lenses and tissues affected by diabetes, indicating its potential as a lead compound for ALR2 inhibition.
12 citations
,
January 1987 in “Carcinogenesis” This study found that a single application of TCDD on the skin of hairless mice altered epidermal differentiation, changing keratin expression patterns similarly to a known tumor promoter.
9 citations
,
July 2022 in “International Journal of Molecular Sciences” This study suggests that prenatal exposure to THC may negatively impact ovarian health in rats by altering miRNA expression, potentially leading to reproductive issues such as subfertility or premature reproductive senescence.
5 citations
,
July 1999 in “Journal of Anatomy” This study found that methylene blue staining may reveal anatomical details of intraepidermal nerve fibre endings in the rat mystacial pad with greater clarity than the zinc iodide-osmium tetroxide technique.
5 citations
,
July 1999 in “Journal of Anatomy” This study observed that methylene blue staining and zinc iodide-osmium tetroxide techniques effectively revealed anatomical details of intraepidermal nerve fibre endings in the rat's mystacial pad, suggesting their potential role in mechanoreception.
4 citations
,
January 2001 in “Archives of Biochemistry and Biophysics” This study found that TPA induces apoptosis in pig renal epithelial cells by affecting cell cycle proteins, and activated ras can prevent this process.
3 citations
,
April 2025 in “International Journal of Molecular Sciences” This review evaluates the anti-aging properties of TSG from He shou wu, finding it may protect against age-related diseases through multiple mechanisms, though further research is needed for clinical application.