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Increased free testosterone can lead to stronger bones and less body fat but also higher risks of prostate cancer, hair loss, spine issues, and high blood pressure.

Testosterone's role in women's sex drive is unclear and needs more research, as low levels don't always mean less sexual interest and high levels can cause side effects.

Higher testosterone levels can increase the risk of certain diseases like type 2 diabetes in women and prostate cancer in men, but can also protect against autoimmune diseases and hair loss. It also affects body fat and bone density.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Hormone treatments in transsexual individuals reduce hair growth and oil production in male-to-females and increase them in female-to-males.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Hormone treatment for transgender patients may not need to be stopped before surgery, but more research is needed, especially on estrogen.

Some medications can cause acne, and stopping these drugs is the main treatment.

New treatments for low male hormones improved sexual function and mood but had unclear risks, especially for older men.

Advancements in male reproductive medicine are ongoing, but more research and improved treatments are needed in several areas.

Testosterone replacement can help menopausal women with various symptoms, but should be used carefully and is not yet officially licensed in the UK for women.

Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.

Sex hormone treatments can increase muscle mass in older adults but have inconsistent effects on muscle function and may carry cardiovascular risks.

Testosterone may influence COVID-19 severity and outcomes.

The document concludes that personalized hormonal treatments are important for transgender individuals and more research is needed for non-binary treatments.

There are various effective hormone treatments for puberty induction in boys and girls with hypogonadism, and starting treatment early is important.

Pre-operative hormone treatment for hypospadias surgery might improve outcomes, but more research is needed to confirm.

Rosemary leaf extract may be an effective natural treatment for hair growth and male pattern baldness.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

Transgender patients need proper skin care, especially when undergoing hormone treatments, to manage issues like acne and hair loss.

Cuscuta reflexa extracts and an isolate promoted hair growth and could be natural treatments for hair loss.

PCOS is a complex condition with major health impacts, needing more research for better diagnosis and treatment.

Hormone therapy and surgeries for transgender individuals affect their skin and hair, requiring specific dermatologic treatments and respectful care.

Menopause often leads to lower sexual desire and discomfort during sex, but treatment should be personalized and only if it bothers the woman.

Hormones significantly affect women's sexual function, and more research is needed to improve treatments for sexual dysfunction with minimal side effects.

A new method helps detect androgen receptor movement in cells, aiding research on hair loss treatments.

The document covers various male health issues, their causes, treatments, and related conditions.

Most youth with gender dysphoria received hormones, had minor complications, and showed a decrease in suicide attempts after treatment.

The seeds of Abrus precatorius, when processed, can prevent hair loss more effectively than common treatments.

The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.