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Researchers developed reliable models to predict how well certain compounds bind to androgen receptors, emphasizing the importance of atomic electronegativity.

The document says that early treatment of Acne Vulgaris is important to prevent scarring and that adult onset acne is common in women, often due to hormonal imbalances.

Lifestyle changes like diet and exercise are key for treating overweight women with polycystic ovary syndrome.

The hypothesis suggests that PCOS may start early in life due to genetic and environmental factors, influencing future reproductive and metabolic problems.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

Finasteride effectively treats BPH, but needs more trials to understand potential.

Metformin is effective for treating excessive hair growth in women with PCOS and may work better than the standard treatment in some ways.

Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.

Spironolactone is a safe and effective treatment for reducing excessive hair growth in women.

Estrogen therapy can reduce skin aging but has cancer risks.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.

TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

Finasteride works better than Permixon in reducing dihydrotestosterone levels.

Shrinking skin cancer increases the chance of cancer in nearby lymph nodes.

The conclusion is that the best initial treatment for hirsutism is usually oral contraceptives, with the addition of antiandrogens or insulin sensitizers if needed, and topical eflornithine or laser treatments as supplementary options.

Low-dose finasteride effectively treats hirsutism, is safe, and cost-effective.

Metformin has limited effectiveness for improving PCOS symptoms and lacks clear benefits, needing more research to confirm its efficacy.

Cyproterone acetate plus ethinyl estradiol is generally more effective in treating hirsutism, but consider side effects and patient characteristics.

Using steroids can increase the risk of heart problems.

Androgen is important in controlling stem cell differentiation, reducing fat development, and increasing lean mass.

The document concludes that treating PCOS requires a combination of drugs to manage reproductive and metabolic symptoms, with more research needed on combination therapies.

Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.

Finasteride reduces male rat fertility by causing issues with copulatory plug formation.

DHT's role in hair loss is important, but measuring its level for diagnosis is questionable.

Chlormadinone acetate is a strong, well-tolerated hormone used in birth control and hormone therapy with benefits for menstrual pain and skin conditions.

Finasteride reduces hair growth and is safe for women with excessive hair.