22 citations
,
March 2000 in “Clinical endocrinology” This study found that while ethinyl oestradiol and cyproterone acetate effectively treated hirsutism in 90% of patients, 80% experienced relapse within six months after stopping treatment, suggesting long-term use is necessary.
16 citations
,
January 2023 in “Cureus” This article discusses the characteristics and potential consequences of polycystic ovarian syndrome, including its effects on fertility and risk for other health conditions, but it reports no new findings.
16 citations
,
January 2006 in “The Aging Male” This review discusses various skin diseases with endocrinological origins and reports no clinical results, highlighting the need for interdisciplinary understanding in diagnosis.
14 citations
,
August 2014 in “Applied Physiology, Nutrition, and Metabolism” This study concluded that an 8-week low-starch/low-dairy diet increased fat oxidation in overweight and obese women with PCOS.
14 citations
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September 2007 in “Steroids” This study suggests that androstendione and DHEA are useful indicators for diagnosing hyperandrogenemia in hirsute women, while DHEAS was not found to be helpful.
13 citations
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January 2012 in “International Journal of Trichology” In this study, idiopathic hirsutism was identified as the most common cause of hirsutism among the participants, with a significant difference in hormone levels between cases of polycystic ovarian syndrome and idiopathic hirsutism.
12 citations
,
January 1991 in “Archives of dermatological research” Male hormones control a specific gene in hamster skin, with different hormones having varying effects.
9 citations
,
November 2013 in “Presse Medicale” This article discusses clinical features and treatment options for hyperandrogenism in women and does not report new findings, highlighting current practices in diagnosis and management.
9 citations
,
August 2000 in “Journal of Periodontal Research” Finasteride reduces testosterone conversion, progesterone lessens this, and levamisole enhances finasteride's effect.
9 citations
,
August 1952 in “The Journal of Clinical Endocrinology & Metabolism” This study describes a method to estimate endogenous hormone production by neutralizing an endogenous hormone with an oppositely acting hormone.
7 citations
,
October 2019 in “Case reports in endocrinology” This case report describes a woman with hyperandrogenism and menstrual disturbances, where an ovarian steroid cell tumor was identified and removed, leading to resolution of symptoms.
7 citations
,
January 2016 in “Experimental and Clinical Endocrinology & Diabetes” This study observed that adding simvastatin to ongoing metformin treatment reduced certain androgen levels in women with non-classic congenital adrenal hyperplasia and abnormal glucose metabolism, suggesting a potential therapeutic benefit.
5 citations
,
October 2018 in “Medical Science Monitor” This study concluded that PCOS patients, regardless of weight, have significantly lower serum amylin levels than healthy BMI-matched controls, while serum preptin levels did not vary significantly between groups.
5 citations
,
October 2016 in “European Journal of Obstetrics & Gynecology and Reproductive Biology” This study found that women with PCOS had significantly prolonged nasal mucociliary clearance time, which may increase their susceptibility to respiratory tract and middle ear infections.
5 citations
,
October 2013 in “Endocrine” This case report describes three instances where occult ovarian Leydig cell tumors were suspected based on severe hyperandrogenism symptoms, despite negative imaging findings, highlighting that elevated testosterone levels are a crucial diagnostic marker.
5 citations
,
October 2010 in “General and Comparative Endocrinology” In this study, pregnant spotted hyenas treated with flutamide and finasteride had lower concentrations of several sex hormones, including testosterone and luteinizing hormone, compared to untreated controls.
3 citations
,
March 2021 in “Metabolites” This study identified distinct differences in metabolic pathways related to pattern baldness, with findings highlighting the androgen metabolic pathway in males and the estrogen plus arachidonic acid pathways in females using hair samples.
3 citations
,
January 2018 in “Postępy Dermatologii i Alergologii” This study suggests that SRD5A2 polymorphisms may increase the risk of acne in individuals with normal serum testosterone levels, particularly in the Chinese population.
3 citations
,
June 2016 in “Gynecological Endocrinology” Doctors used a special blood sampling technique to diagnose a woman's rare ovarian tumor that was producing male hormones.
2 citations
,
July 2024 in “Ibn AL- Haitham Journal For Pure and Applied Science” This study found that PCOS women with COVID-19 had lower ACE2 levels and higher insulin resistance, suggesting increased cardiovascular risk.
2 citations
,
November 2017 in “Elsevier eBooks” This article discusses the role of the androgen receptor in regulating development and homeostasis, and reviews treatment approaches for conditions related to hormone imbalances, without reporting new clinical findings.
2 citations
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November 2011 in “InTech eBooks” This article reviews the types and characteristics of adrenal cortex tumors, including their hormone secretion and detection as incidental findings, but presents no new research results.
2 citations
,
December 1994 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study concluded that a regimen of transdermal estradiol and oral medroxyprogesterone acetate effectively reduces hirsutism while minimizing side effects in women with polycystic ovary syndrome.
2 citations
,
August 1987 in “Australasian Journal of Dermatology” This review discusses skin diseases related to contraceptive use, reporting potential issues with oral contraceptives and infrequent reactions to mechanical or barrier methods without new clinical findings.
1 citations
,
August 2024 in “Indian Dermatology Online Journal” In this case report, researchers observed that a female patient with severe hidradenitis suppurativa experienced complete resolution of her lesions after starting intramuscular exogenous testosterone as part of gender transition, suggesting its potential role in disease remission when other treatments were ineffective.
1 citations
,
June 2017 in “International journal of reproduction, contraception, obstetrics and gynecology” This study found that N-acetylcysteine was as effective as metformin in improving insulin resistance and metabolic syndrome parameters in women with polycystic ovary syndrome, with fewer side effects.
This review discusses genetic and epigenetic studies of PCOS, highlighting Genome-Wide Association Studies that found genetic variants related to gonadotrophin secretion influencing PCOS susceptibility, but it reports no new findings.
1 citations
,
February 2014 in “Archiv Der Pharmazie” This study demonstrated that steroidal carbamates 7–10 altered mRNA expression related to lipid metabolism in hamster flank organs and inhibited 5α-reductase activity without binding to the progesterone receptor.
1 citations
,
September 2012 in “Expert Review of Endocrinology & Metabolism” This review discusses the clinical implications of female androgen deficiency and evaluates treatment options, emphasizing the need for cautious use of replacement therapy in women with severe deficiency and matching symptoms.
1 citations
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March 2012 in “Journal of Dermatological Science” This study found that various steroids affected the mRNA expression of enzymes involved in lipid metabolism in hamster flank organs, with different impacts depending on the steroid and combination used.