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Dutasteride effectively treats benign prostatic obstruction, improves urinary flow, reduces prostate size, and may prevent prostate cancer, but can cause sexual side effects.

Removing part of the vitamin D receptor stops vitamin D from working properly.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

Diagnosing hyperandrogenism in women is complex and requires accurate testing methods and consideration of SHBG levels.

A low-starch/low-dairy diet may help overweight women with PCOS lose weight and improve metabolism, but more research is needed.

5α-reductase inhibitors may worsen sexual drive and spontaneous erections but don't worsen existing erectile or ejaculatory problems.

Finasteride and analogues separated using LC-MS-MS technique.

Finasteride treatment changes urine metabolomics and steroid signatures, potentially monitoring effectiveness but may cause sexual side effects.

LC-MS/MS is more reliable than immunoassays for diagnosing 21-hydroxylase deficiency.

ADT-G may be a useful indicator of increased androgen levels in women with acne and can be lowered with certain birth control pills.

Women with effluvium have higher levels of certain urinary steroids, possibly due to stress and increased adrenal activity.

Overweight women with PCOS have higher levels of certain hormones that could indicate a higher risk of heart and metabolic problems.

Dutasteride is more effective than finasteride for hair loss treatment.

Anti-androgens are effective for female acne but less so for male-pattern hair loss, with side effects similar to birth control pills.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

Finasteride doesn't affect antipyrine metabolism, so interactions with cytochrome P-450 enzyme drugs are unlikely.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

The method reliably profiles eicosanoids and shows epitestosterone reduces their levels, similar to common anti-inflammatory drugs.

Lower adrenal hormone levels may cause hair loss in postmenopausal women, certain patterns help diagnose nail cancer, and a gene variant linked to higher skin cancer risk in kidney transplant patients suggests monitoring folate levels.

Women with PCOS have different levels of certain fats and proteins in their blood, which could help diagnose the condition.

The method effectively detects banned substances in urine for sports antidoping.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Progesterone treatment improved seizures in a woman with menstrual cycle-related epilepsy, but a wrong medication worsened her condition.

5α-reductase inhibitors help treat disorders caused by DHT and have potential for future therapies.

Isotretinoin and tazarotene help treat acne, while minoxidil and finasteride promote hair growth.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.