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Women with PCOS have a higher risk of metabolic syndrome and need lifestyle changes and treatment.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Childhood obesity is rising globally due to various factors, and early prevention and healthy lifestyle changes are crucial.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Oxidative stress contributes to hair graying and loss as we age.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

Hair ages due to genetics and environmental factors, leading to graying and thinning, with treatments available for some conditions.

Amenorrhea is relatively rare and initial testing should check FSH, TSH, and prolactin levels.

Eating healthy, exercising, and taking certain supplements can help manage Polycystic Ovary Syndrome symptoms.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Steroidogenic isoenzymes may help improve treatments for common hair loss.

The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.

Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.

Men with less sun-sensitive skin have lower PSA levels, while men with more sun-sensitive skin have higher PSA levels.

Hair ages due to various factors and treatments like minoxidil and finasteride can help, but more research and better public awareness are needed.

Heredity and hormones cause common hair loss, and topical minoxidil is the first recommended treatment.

Hormone imbalances from the pituitary, thyroid, and adrenal glands can cause infertility, but treating these disorders can improve fertility.

Histone demethylases play a key role in the development of many diseases and may be targets for treatment.

Certain gene variations are linked to a higher risk of severe acne, suggesting a genetic influence on the condition.

Cancer rates are increasing in developed countries, with estrogen, aging, low vitamin D3, and HPV infection as common causes.

Genetic mutations can affect female sexual development, requiring personalized medical care.

Inflammasome proteins can indicate the severity and treatment response of various diseases and injuries.

Skin lesions in Carney Complex are caused by a gene change in some skin cells that leads to increased pigmentation and may lead to tumors.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

Certain genetic mutations can lower bad cholesterol and reduce heart disease risk, leading to effective cholesterol-lowering drugs.

Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.

Platelet-rich plasma (PRP) injections can effectively increase hair density and thickness in people with androgenic alopecia, without major side effects.