research 5α-Reductases in Human Physiology: An Unfolding Story
We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.
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research Effects of Finasteride, a 5 Alpha-Reductase Inhibitor, on Circulating Androgens and Gonadotropin Secretion in Hirsute Women
Finasteride reduces dihydrotestosterone, increases testosterone, and may treat hirsutism in women.
research Cyproterone Acetate as Initial Treatment and Maintenance Therapy for Hirsutism
Cyproterone acetate is effective for treating hirsutism, but some patients may feel worse on low-dose maintenance therapy.
research Management of Endocrine Disease: Hyperandrogenic States in Women - Pitfalls in Laboratory Diagnosis
Diagnosing hyperandrogenism in women is complex and requires accurate testing methods and consideration of SHBG levels.
research The Diversity of Sex Development: What Conditions Affecting Sex Development Teach Us About Sexual Diversity
Conditions affecting sex development show that sexual diversity is a natural part of human variation.
research Challenges in the Assessment and Diagnosis of Polycystic Ovary Syndrome
Diagnosing Polycystic Ovary Syndrome is hard due to varying symptoms, no set criteria, and the need for better tests and education.
research Review on Methods and Mechanisms for Producing Polycystic Ovary Syndrome (PCOS) in Animal Models: Experimental Purpose (Pre-Clinical Studies)
The document concludes that there are multiple ways to create PCOS in animals for research, which helps understand and treat the condition.
research Diagnosis of an Indistinct Leydig Cell Tumor by Positron Emission Tomography-Computed Tomography
A PET-CT scan successfully located a hard-to-find Leydig cell tumor in a woman with hormonal symptoms.
research Definition of Hyperandrogenism
The document suggests new ways to assess and diagnose hyperandrogenism to improve accuracy.
research When Acne, Hirsutism, and Menstrual Irregularities Are More Than PCOS
Non-classic congenital adrenal hyperplasia (NCCAH) can mimic PCOS and requires genetic testing for proper diagnosis and treatment.
research Androgen Profile in Chinese Women with Polycystic Ovary Syndrome in Their Reproductive Years
Chinese women with PCOS have higher androgen levels, which change with age and weight.
research Exogenous Testosterone, Finasteride, and Castration Effects on Testosterone, Insulin, Zinc, and Chromium in Adult Male Rats
Testosterone and finasteride raise insulin and zinc, lower chromium in male rats.
research Testosterone Supplementation for Aging-Associated Sarcopenia
Testosterone supplements can increase muscle mass and strength in older men with low levels, but long-term effects and risks need more research.
research Safety of Testosterone Use in Women
Short-term testosterone therapy in women seems safe with few mild side effects, but long-term effects need more research.
research Exogenous Testosterone Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum Testosterone
Testosterone therapy improves physical function, strength, and body composition in older men with low testosterone levels.
research Exogenous Testosterone or Testosterone with Finasteride Increases Bone Mineral Density in Older Men with Low Serum Testosterone
Testosterone therapy increases bone density in older men with low testosterone levels.
research Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production
Testosterone's muscle-building effects do not require its conversion to DHT.
research Sex Hormone-Binding Globulin: An Important Biomarker for Predicting PCOS Risk - A Systematic Review and Meta-Analysis
Lower SHBG levels may increase the risk of PCOS.
research Low Sex Hormone-Binding Globulin Is Associated With Low High-Density Lipoprotein Cholesterol And Metabolic Syndrome In Women With Polycystic Ovary Syndrome
Women with PCOS who have low SHBG are more likely to have low good cholesterol and metabolic syndrome.
research Sex Hormone-Binding Globulin as an Early Biomarker and Therapeutic Target in Polycystic Ovary Syndrome
SHBG may be a useful early indicator and treatment target for PCOS.
research Testosterone Improves Antidepressant-Emergent Loss of Libido in Women: Findings from a Randomized, Double-Blind, Placebo-Controlled Trial
Testosterone may help increase sexual events for women with low libido due to antidepressants.
research Sex Hormones Modulate Pathogenic Processes in Experimental Traumatic Brain Injury
Sex hormones affect brain injury differently in males and females.
research Hormone Therapy in Acne
Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.
research Testosterone Therapy in Premenopausal Women
Testosterone therapy may improve mood, well-being, and sexual function in premenopausal women, but more research is needed on its long-term safety and effectiveness.
research Ovarian Hilus-Cell Hyperplasia and High Serum Testosterone in a Patient With Postmenopausal Virilization
A woman's male-like symptoms and high testosterone were due to ovarian hilus-cell hyperplasia, which improved after surgery.
research Administration of Caesalpinia Bonduc Seed Extracts Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia in Male Wistar Rats
Caesalpinia bonduc seed extracts may help treat enlarged prostate in rats.
research The Five-Year Effects of Testosterone Replacement Therapy on Lipid Profile and Glucose Tolerance Among Hypogonadal Men in Japan: A Case Control Study
Testosterone replacement therapy improved blood sugar and fat levels without raising prostate cancer risk in Japanese men with low testosterone.
research Evaluation of Efficacy, Safety, and Reversibility of Combination Regimen of Cyproterone Acetate and Testosterone Buciclate in Bonnet Monkeys
The right dosage of CPA and TB can work as a safe and reversible male contraceptive in monkeys.
research Effect of Cosmetic Hair Treatment and Natural Hair Color on Hair Testosterone Concentrations
Cosmetic hair treatments can increase hair testosterone levels, while natural hair color does not affect it.
research Relationship Between Glucose Homeostatic Disorders and Testosterone in Adult Nigerian Women With Polycystic Ovary Syndrome
Higher testosterone levels in Nigerian women with PCOS are linked to glucose disorders like diabetes.