59 citations,
September 2003 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” Epitestosterone may counteract testosterone's effects and has roles in body processes like prostate growth and hair distribution.
14 citations,
July 2016 in “Toxicology and Industrial Health” Low doses of BPA can increase prostate growth and change hormone levels in adult rats.
November 2023 in “Research Square (Research Square)” Finasteride affects the male rat brain by reducing certain protein activation, but these effects may reverse after stopping the drug.
July 2023 in “International journal of life science and pharma research” The herbal hair cream could help treat male pattern baldness by blocking a baldness-related enzyme and might be worth further investigation.
April 2007 in “9th European Congress of Endocrinology” Finasteride, a hair loss medication, was found to be safe and effective in improving hair quality and stopping hair loss in men with early-onset baldness.
March 2023 in “Journal of Applied Biomedicine” Oleanolic acid improved hair growth in mice by affecting hair growth pathways and reducing inflammation.
57 citations,
January 1986 in “The Prostate” The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.
10 citations,
December 2019 in “in Vivo” Testosterone makes the connections in the uterus lining simpler and lowers certain protein levels, which might lead to infertility.
June 2022 in “International journal of drug delivery technology” Convolvulus arvensis ethanolic extract can potentially promote hair growth and reduce hair loss.
8 citations,
March 2020 in “Frontiers in Cell and Developmental Biology” Researchers created immortal human skin cells with constant testosterone receptor activity to study hair loss and test treatments.
8 citations,
July 2018 in “Analytical sciences” Using 5-butylpicolinate esters improves the sensitivity and reliability of detecting testosterone and dihydrotestosterone in saliva.
1 citations,
January 2008 in “Proceedings of the 9th World Rabbit Congress, Verona, Italy, 10-13 June 2008” Furless male rabbits grew slightly faster and heavier than furred ones, but testosterone levels were not the cause.
August 1993 in “Journal of Dermatological Science” Testosterone metabolism in balding scalp cells may not be the main cause of hair loss.
15 citations,
August 2016 in “Current Urology Reports” Nandrolone and oxandrolone could help treat male health issues like muscle loss and low testosterone.
13 citations,
October 2002 in “Journal of Biochemical and Biophysical Methods” Men with male-pattern baldness have higher levels of certain testosterone metabolites and may have more active androgen metabolism.
June 2022 in “Journal of Experimental Biology and Agricultural Sciences” Higher testosterone harms sperm motility, while higher estradiol improves sperm survival.
110 citations,
January 2014 in “The Journal of Sexual Medicine” Testosterone treatment in trans men increases body and facial hair and may lead to hair loss over time, but severe skin issues are rare.
38 citations,
July 1989 in “Archives of dermatological research” Testosterone causes hair loss in AGA mice, which are good for testing baldness treatments, and both minoxidil and cyproterone acetate can prevent this hair loss.
14 citations,
July 2011 in “Experimental Dermatology” Applying EGCG on the skin can prevent hair loss caused by testosterone in mice.
3 citations,
February 2021 in “Molecules” A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.
1 citations,
January 2015 in “Hair therapy & transplantation” Some supplements and hormones can increase hair loss by raising DHT levels.
41 citations,
March 1998 in “Archives of Dermatological Research” The enzyme that changes testosterone to a stronger form is mostly found in the part of the hair follicle called the dermal papilla.
January 2023 in “Iranian Journal of Pharmaceutical Research” Stauntonia hexaphylla extract can help treat hair loss by blocking certain hormones.
18 citations,
March 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Estrogen increases blood vessel growth factor production, while testosterone blocks this increase.
15 citations,
January 2009 in “International Journal of Andrology” Liquorice may reduce testosterone and affect male reproductive organs, potentially helping treat conditions like prostate cancer.
77 citations,
May 2012 in “Expert Opinion on Emerging Drugs” New treatments for male hypogonadism are effective and should be personalized.
August 2023 in “International Journal For Multidisciplinary Research” Ayurvedic treatment, exercise, and a healthy diet can effectively manage PCOD symptoms.
193 citations,
August 1985 in “Endocrinology” Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.
82 citations,
February 1989 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.
59 citations,
August 1998 in “International Journal of Dermatology” Genetics and hormones cause hair loss; finasteride treats it safely.