research Sulfatase Inhibitors: A Patent Review
The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.
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research Idiopathic Hirsutism: Androgen Role and Treatment Options
The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.
research Hormonal Treatment of Acne Vulgaris: An Update
Hormonal treatments are effective for severe or persistent acne and should be used with other acne therapies, considering potential side effects.
research 5α-Reduced Glucocorticoids: A Story of Natural Selection
Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.
research Non-Classic Congenital Adrenal Hyperplasia
Non-classic congenital adrenal hyperplasia is a common disorder causing symptoms like acne and infertility, and it's managed based on symptoms, not just test results. Treatment can improve fertility and reduce miscarriage risk.
research Does Prolactin Play a Role in Skin Biology and Pathology?
Prolactin may be important for skin growth and immune function.
research Prevalence of CYP21 Mutations and IRS1 Variant Among Women With Polycystic Ovary Syndrome and Adrenal Androgen Excess
Some women with PCOS have CYP21 mutations and IRS1 variants, but these genetic factors are not major contributors to PCOS.
research Contribution of the Hair Follicular Pathway to Total Skin Permeation of Topically Applied and Exposed Chemicals
The hair follicle pathway significantly affects how easily water-loving chemicals pass through the skin.
research Role of Insulin Resistance and Diet in Acne
Eating high glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.
research Topical Melatonin for Treatment of Androgenetic Alopecia
Melatonin solution helps treat hair loss in men and women.
research Xenobiotic-Metabolizing Enzymes in the Skin of Rat, Mouse, Pig, Guinea Pig, Man, and in Human Skin Models
Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.
research The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog Silurana Tropicalis
Fadrozole and Finasteride change frog sex ratios and cause intersex animals with altered gene expressions.
research Side Effects of 5-Alpha Reductase Inhibitors: A Comprehensive Review
5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.
research Interventions for Female Pattern Hair Loss
Minoxidil effectively treats female pattern hair loss.
research Repurposing Existing Drugs for COVID-19: An Endocrinology Perspective
Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.
research Pharmacotherapy of Polycystic Ovary Syndrome: An Update
New treatments for PCOS show promise, but no current medication treats all aspects of the condition.
research Retrospective Evaluation of Sex Hormones and Steroid Hormone Intermediates in Dogs with Alopecia
Most dogs with alopecia had higher than normal levels of certain hormones, but hair loss might not always be linked to these hormone changes.
research Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome
The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.
research Cutaneous Manifestations of Eating Disorders
Eating disorders can cause skin problems that need treating the underlying condition for better health.
research Sex Hormones Modulate Pathogenic Processes in Experimental Traumatic Brain Injury
Sex hormones affect brain injury differently in males and females.
research Dutasteride Reduces Alcohol’s Sedative Effects in Men in a Human Laboratory Setting and Reduces Drinking in the Natural Environment
Dutasteride makes alcohol less sedating and may lead to less drinking in men.
research Effects of Curcumin on Glycemic Control and Lipid Profile in Polycystic Ovary Syndrome: Systematic Review with Meta-Analysis and Trial Sequential Analysis
Curcumin may improve blood sugar levels and cholesterol in people with PCOS, but more research is needed.
research New Steps Forward in the Neuroactive Steroid Field
Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.
research Steroidogenic Isoenzymes in Human Hair and Their Potential Role in Androgenetic Alopecia
Steroidogenic isoenzymes may help improve treatments for common hair loss.
research Acanthosis Nigricans and the Metabolic Syndrome
Acanthosis nigricans is a skin condition that may indicate a higher risk for insulin resistance and type 2 diabetes, and more research is needed to understand and treat it.
research In Silico Prediction of Prostaglandin D2 Synthase Inhibitors from Herbal Constituents for the Treatment of Hair Loss
Herbal compounds like ricinoleic acid, quercetin-3-O-rutinoside, and hinokiflavone may be safe and effective for treating hair loss.
research Nonclassic Congenital Adrenal Hyperplasia: Pathophysiology, Genetics, and Management
Nonclassic congenital adrenal hyperplasia is a genetic disorder causing hormone imbalances, affecting fertility and requiring personalized treatment.
research Management of Congenital Adrenal Hyperplasia During Pregnancy
With careful management, people with congenital adrenal hyperplasia can have successful pregnancies and become parents.
research The VEGF +405 G>C 5' Untranslated Region Polymorphism and Risk of PCOS: A Study in South Indian Women
The VEGF +405G allele may increase the risk of PCOS in South Indian women.
research New Approaches to the Treatment of Osteoporosis
Future osteoporosis treatments should focus on increasing bone growth, with many promising options available.