April 2026 in “Cosmetics” This study developed and tested a shampoo with semi-permanent dyes designed to gradually cover gray hair, reporting maintained stability and effective gray–black coloration on high-canities hair tresses through eight wash cycles.
December 2025 in “Journal of Pharma Insights and Research.” This study explains the formulation and evaluation of a natural polyherbal shampoo, which effectively colors hair and provides conditioning without the dermal and systemic toxicity risks of synthetic dyes, offering an effective alternative to conventional products.
January 2025 in “International Journal of Advanced Research in Science Communication and Technology” Results are not reported for this study exploring how herbal hair dye, made from natural plant-based ingredients, might promote glossier, longer, and thicker hair while covering gray.
33 citations
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August 1985 in “Archives of Dermatology” This study suggests that acquired progressive kinking of hair, which typically appears at or after puberty, may be androgen dependent and could progress to male pattern baldness.
5 citations
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July 2017 in “Women & Health” This study found that nursing women in the West Bank of Palestine who lived in cities and consumed energy beverages had higher blood zinc levels.
January 2019 in “Durham e-Theses (Durham University)” This study utilized advanced imaging techniques to quantify hair damage and dye uptake dynamics, revealing that compound penetration in hair is influenced by molecule size and lipophilicity.
January 2013 in “Springer eBooks” Hair care products are important for appearance and self-esteem, and choosing the right ones can help maintain healthy hair.
November 2011 in “Informa Healthcare eBooks” Environmental, chemical, mechanical, and personal health factors can all damage hair and contribute to hair loss or changes in hair quality.
8 citations
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August 2020 in “International Journal of Molecular Sciences” This study found that in Arabidopsis root hairs, oscillating cytoplasmic potassium dynamics precede growth oscillations, suggesting a complex interplay with calcium signaling and microfilament structure in regulating root hair growth.
3 citations
,
June 2008 in “Springer eBooks” Hair care products clean, protect, style, color, and change hair structure.
12 citations
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May 2013 in “International Journal of Dermatology” This study found that a non-ionic ethosomal carrier system significantly improved the delivery and adsorption of black tea extracts onto hair surfaces in vitro, suggesting its potential as a hair dye and protective agent.
2 citations
,
November 2025 in “Pharmaceutics” This study found that a CLSM-based approach could semi-quantitatively assess the transdermal penetration behavior of fluorescent dyes with different lipophilicities, offering a tool for early-stage screening of compound penetration.
47 citations
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June 2015 in “Contact Dermatitis” This review discusses the need for an updated 'European hair cosmetic series' to include common contact allergens and remove outdated substances based on current evidence and regulations, but it reports no new results.
34 citations
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January 2016 in “Analytical Chemistry” This study reports that a new DART-HRMS method can effectively analyze intact hair for drug use timelines, with cocaine detection aligning with forensic standards and identifying multiple drugs from high-resolution data.
1 citations
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May 2023 in “Frontiers in medicine” This review explores how hair dyes and perms can damage hair structure and notes that while some adverse outcomes like skin irritation and allergic reactions have been reported, evidence from human studies remains inconsistent regarding potential risks, including cancer.
January 1990 in “Springer eBooks” Some chemicals can permanently or temporarily remove color from skin and hair, which can be distressing and is not well-regulated in cosmetics.
December 2025 in “Applied and Computational Engineering” In this study, researchers explored the potential allergenicity and harmful effects of hair dyes, noting that adverse effects such as sensitization and potential carcinogenicity are not inevitable and can vary based on individual physiological differences.
June 2021 in “Journal of emerging technologies and innovative research” This article reviews the potential hair-protective effects of Onion and Aloe vera against damage from hair dyes but reports no new experimental results.
13 citations
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June 2021 in “Carcinogenesis” In this study, frequent use of hair straighteners/relaxers and pressing products was associated with an increased risk of ovarian cancer, with potential variation in risk by tumor type noted for permanent hair dyes.
This study evaluated various herbal blends of powdered leaves, including Henna and Indigo, for their coloring and sensitivity reactions, finding Henna and Indigo to be effective natural colorants for achieving a reddish-brown hair color with better retention than marketed herbal hair dyes.
January 2024 in “Wiadomości Lekarskie” This research explores innovative methods to enhance drug delivery to the brain, including techniques like focal intra-arterial administration and temporary blood-brain barrier opening, aimed at improving treatment for brain disorders, the authors report.
6 citations
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March 2015 in “European Journal of Public Health” This study suggests that long-term use of hair dyes may be associated with higher testosterone levels among premenopausal Japanese women.
May 2023 in “Indian Journal of Dermatology” In this study, researchers observed temporary skin reactions at BCG vaccination sites following the Pfizer-BioNTech COVID-19 mRNA vaccine in five patients, suggesting underreported occurrences.
January 2023 in “Fashion and textiles” This study found that hair dyed with anionic basic hair dye lost more color after shampooing compared to cationic and nonionic dyes, with alkaline shampoo increasing this effect.
98 citations
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November 2002 in “Contact Dermatitis” This study found that adverse reactions to para-phenylenediamine in hair dye, including severe allergic contact dermatitis, may be more common than currently reported and often misdiagnosed.
2 citations
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January 2023 in “International journal of biological sciences” This review discusses the mechanisms of hair repigmentation and reports no clinical results; the authors suggest further research into topical treatments for reversing gray hair.
March 2013 in “Molecular & Cellular Toxicology/Molecular & cellular toxicology” In this study, exposure to m-Aminophenol in human keratinocytes altered the expression of thousands of genes involved in inflammation and stress responses, suggesting potential biomarkers for MAP-induced skin toxicity.
14 citations
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January 2015 in “Skin appendage disorders” This case report details two women with female pattern hair loss who experienced severe scalp allergic contact dermatitis from minoxidil, one due to the active ingredient and the other due to the vehicle.
4 citations
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January 2018 in “Urology & Nephrology Open Access Journal” This case report details an instance of acute kidney injury following the inhalation of hair dye during a hairstyle session.
July 2023 in “International Ayurvedic medical journal” In this single case study, Ayurvedic treatments using Madhuka taila nasya and Japaakusumadi lepa were reported to benefit a patient with premature hair graying, suggesting a potential safe and effective alternative to conventional methods.