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This study found that in patients with alopecia areata, serum granulysin levels decreased significantly after treatment with tofacitinib and correlated with reduced disease severity, suggesting serum granulysin as an indicator of immunological activity and response to therapy.

In this study, researchers developed an in-situ gel formulation of antibacterial Levofloxacin for the eye, which showed prolonged drug release, increased residence time, and effective antibacterial action, suggesting it may be a safe and effective ocular delivery system for antibiotics.

This review highlights the significant risks posed by mercury to the endocrine system, including disruptions in hormone synthesis and regulation, stress response, and potential reproductive dysfunction, while noting the need for further research on dose-response relationships and long-term impacts.

This systematic review and meta-analysis found that platelet-rich plasma (PRP) therapy is effective in increasing hair density and reducing hair loss for alopecia, with variations in response based on activation status.

This study developed and characterized Quercetin-loaded nanogels, finding that they showed promising potential for enhanced drug delivery and stability in treating Alopecia, with an optimized batch achieving a drug release of 95.32% over 12 hours.

This review outlines the potential of nanoemulsion-based hydrogels (nanoemulgels) for enhanced topical and transdermal drug delivery in treating skin disorders, highlighting their ability to improve therapeutic efficacy, control drug release, and boost patient compliance.

This research highlights the potential of emulgel as an advanced topical drug delivery system, offering improved efficacy for hydrophobic medications in treating dermatological conditions and a range of ailments with its dual release control mechanism of gel and emulsion.

This study reported that a solid lipid nanoparticle-based gel formulation, specifically optimized for psoriasis, improved drug loading capacity and release properties using high-pressure homogenization, suggesting its potential efficacy as a topical treatment.

This study found that a chitosan-decorated finasteride nanosystem exhibited satisfactory drug release and retention in rat skin, suggesting it could enhance topical delivery for androgenic alopecia treatment.

This study by Moore et al. (2025) provides the first evidence linking C-tactile afferents in humans to hair follicles, showing that these nerve fibers respond to hair movement rather than skin deformation, adding complexity to the understanding of their role in emotion and touch.

This study explored the molecular mechanisms by which Polygonum multiflorum may treat androgenic alopecia, suggesting it influences cell apoptosis and inflammation through specific pathways, with potential application value pending further testing.

This review article highlights recent advances in microneedle technology for wound healing and tissue regeneration, discussing various cargo types, structural designs, and fabrication methods, and suggesting guidelines for designing microneedle systems tailored to specific applications.

This review assesses the potential of smart dressings, engineered to respond to various stimuli, as advanced treatments for chronic inflammatory skin diseases by examining their activation mechanisms and proposing future developments like integrating AI and closed-loop monitoring for adaptive therapy.

Chitosan-coated nanocapsules improve minoxidil delivery for better hair regrowth.

This study demonstrated that an AR-EGFP transgene can restore AR function and fertility in Sertoli cell-specific AR knockout mice, highlighting its potential use in understanding androgen receptor functions.

This study demonstrated a novel use of tape stripping on a human skin model to simulate the inflammation and barrier damage caused by dry razor shaving, highlighting potential shaving and skin-care formulations that may mitigate such damage.

This study found that TRPV3 ion channels on human epidermal keratinocytes suppress cell proliferation, induce cell death, and trigger a proinflammatory response, suggesting a role in cutaneous inflammatory processes.

This study found that fibroin/gelatin and spidroin microparticles increased re-epithelialization rates and inhibited scar formation in mouse models of deep skin wounds.

This study observed that drug-naïve first-episode psychosis patients had higher hair cortisol concentrations than healthy controls, and these concentrations correlated with the severity of psychopathology.

This review examines the role of skin microbes in enhancing the skin barrier and their involvement in skin diseases like atopic dermatitis, while also discussing current and future therapeutic strategies targeting the skin microbiome.

This review summarizes the influences of lifestyle factors such as smoking, alcohol, and diet on the pathogenesis of alopecia areata but reports no new clinical results.

This study reports that hair follicle-derived mesenchymal stem cells significantly reduced hair loss and inflammation in alopecia areata models, suggesting a potential therapeutic approach.

Skin organoids can mimic human skin responses to injury and inflammation, making them useful for studying skin diseases and testing treatments.

This study aimed to enhance the skin penetration of minoxidil by encapsulating it in glycerosomal vesicles, offering a potential improvement in transdermal drug delivery for treating androgenetic alopecia. Results of the investigation were not reported.

In this study, 20% whale oil applied to mice was observed to promote hair growth more effectively than a control or 3% minoxidil, showing increased hair follicles and thicker subcutaneous tissue.

This review discusses transdermal drug delivery using hydrogel-forming microneedles and highlights their potential for disease treatment, but notes challenges in their clinical application.

This review discusses the unique advantages and challenges of microneedle arrays for vaccine and immunotherapy delivery but reports no new clinical results.

This review examines hydrogel microneedles for transdermal drug delivery, discussing their applications and challenges but reports no new clinical results.

This review discusses the design, properties, and potential applications of smart microneedles, with no new clinical results presented.

This review article highlights how hair follicle-targeting drug delivery systems enhance therapeutic outcomes and reduce side effects for treating conditions like androgenetic alopecia and acne vulgaris. The authors discuss current formulations and evaluate their performance in both preclinical and clinical settings.